Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Phillip J. Muckett"'
Autor:
Lucy Penfold, Angela Woods, Alice E. Pollard, Julia Arizanova, Eneko Pascual-Navarro, Phillip J. Muckett, Marian H. Dore, Alex Montoya, Chad Whilding, Louise Fets, Joao Mokochinski, Theodora A. Constantin, Anabel Varela-Carver, Damien A. Leach, Charlotte L. Bevan, Alexander Yu. Nikitin, Zoe Hall, David Carling
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112396- (2023)
Summary: Emerging evidence indicates that metabolic dysregulation drives prostate cancer (PCa) progression and metastasis. AMP-activated protein kinase (AMPK) is a master regulator of metabolism, although its role in PCa remains unclear. Here, we sho
Externí odkaz:
https://doaj.org/article/11a6b824917b48fc8d5c5b5a9e0faa99
Autor:
Angela Woods, Jennet R. Williams, Phillip J. Muckett, Faith V. Mayer, Maria Liljevald, Mohammad Bohlooly-Y, David Carling
Publikováno v:
Cell Reports, Vol 18, Iss 13, Pp 3043-3051 (2017)
AMP-activated protein kinase (AMPK) plays a key role in integrating metabolic pathways in response to energy demand. We identified a mutation in the γ1 subunit (γ1D316A) that leads to activation of AMPK. We generated mice with this mutation to stud
Externí odkaz:
https://doaj.org/article/ef62f181128e4d0bbe4ebc25109d1987
Autor:
Chad Whilding, Mohammad Bohlooly-Y, Laura A. B. Wilson, Alice E. Pollard, Lucy Penfold, David Carling, Patricia Wilson, Phillip J. Muckett
Publikováno v:
Clinical Science. 135:2393-2408
AMP-activated protein kinase (AMPK) plays a key role in the cellular response to low energy stress and has emerged as an attractive therapeutic target for tackling metabolic diseases. Whilst significant progress has been made regarding the physiologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bae06094ff4e2bea1931b0af71b35ef
https://doi.org/10.1042/cs20210821
https://doi.org/10.1042/cs20210821
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28306 (2011)
LKB1 acts as a master upstream protein kinase regulating a number of kinases involved in diverse cellular functions. Recent studies have suggested a role for LKB1 in male fertility. Male mice with reduced total LKB1 expression, including the complete
Externí odkaz:
https://doaj.org/article/afbcf2ab82aa49a8b0b59da0c7b951cd
Autor:
Sanjay Khadayate, Michael R. Duchen, David M. Smith, Rebeca Fiadeiro, Therese Admyre, Mikael Bjursell, Aurélie Bornot, Luís Martins, Angela Woods, Chad Whilding, Alice E. Pollard, Lucy Penfold, Laura A. B. Wilson, Vassilios N. Kotiadis, Mohammad Bohlooly-Y, Phillip J. Muckett, Jon Read, Michael A. Snowden, Alessandro Sardini, Maryam Clausen, David Carling, Daniel Sutton
Publikováno v:
Nature metabolism
Obesity results from a chronic imbalance between energy intake and energy output but remains difficult to prevent or treat in humans. Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is an important regulator of energy homeostasis1,2,3 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee1b02ac41391ec4802c5558731300e
http://hdl.handle.net/10044/1/69486
http://hdl.handle.net/10044/1/69486
Autor:
Alice E. Pollard, David Carling, Rebecca Graham, Angela Woods, Lucy Penfold, Alexander Yu. Nikitin, Phillip J. Muckett, Shuai Zhang, Tera R. Kent
Publikováno v:
Cancer research. 78(24)
New targets are required for treating prostate cancer, particularly castrate-resistant disease. Previous studies reported that calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) expression is increased in human prostate cancer. Here, we sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd236881a86b6d130bc7cc124dcee63
https://pubmed.ncbi.nlm.nih.gov/30242113
https://pubmed.ncbi.nlm.nih.gov/30242113
Autor:
Angela, Woods, Jennet R, Williams, Phillip J, Muckett, Faith V, Mayer, Maria, Liljevald, Mohammad, Bohlooly-Y, David, Carling
Publikováno v:
Cell Reports
Summary AMP-activated protein kinase (AMPK) plays a key role in integrating metabolic pathways in response to energy demand. We identified a mutation in the γ1 subunit (γ1D316A) that leads to activation of AMPK. We generated mice with this mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::49870e933714bb9d8edb49f9698f149a
https://pubmed.ncbi.nlm.nih.gov/28355557
https://pubmed.ncbi.nlm.nih.gov/28355557
Autor:
Robert D. Goldin, Phillip J. Muckett, Margaret A. Mobberley, Catherine Williamson, Amanda Heslegrave, Melanie Clements, Angela Woods, David Carling, Shadi Abu-Hayyeh, Timothy A. Ryder, Dominic J. Withers, Alan Ashworth, Adam P. Levene
Publikováno v:
Biochemical Journal
LKB1 is a ‘master’ protein kinase implicated in the regulation of metabolism, cell proliferation, cell polarity and tumorigenesis. However, the long-term role of LKB1 in hepatic function is unknown. In the present study, it is shown that hepatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf617d5aa561b471634e6601524e0b8
http://europepmc.org/articles/PMC3262187
http://europepmc.org/articles/PMC3262187
Autor:
Rebecca Kerry Wilson, Lane Jonathan Douglas, Andrew Topping, Joseph D. Santangelo, Robert G. Feldman, Phillip J. Muckett, Zabin N. Younes, Joanne C. Moore, Richard Dobson, Hughes Martin John Glenton, Philippa K. Pribul
Publikováno v:
FEMS Microbiology Letters. 222:263-271
Using an alkaline phosphatase-based genetic screening method, we identified a number of proteins that are potentially located on the outer surface of Group B streptococcus (Streptococcus agalactiae). In an enzyme-linked immunosorbent assay, antisera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09021bb3ade353312ba6953c57fa5c5
https://doi.org/10.1016/s0378-1097(03)00310-0
https://doi.org/10.1016/s0378-1097(03)00310-0
Publikováno v:
The Biochemical journal. 434(3)
Hyperphosphorylation of tau is a hallmark of Alzheimer's disease and other tauopathies. Although the mechanisms underlying hyperphosphorylation are not fully understood, cellular stresses such as impaired energy metabolism are thought to influence th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a17ad2861af17bf8023333d94ec80dd2
https://pubmed.ncbi.nlm.nih.gov/21204788
https://pubmed.ncbi.nlm.nih.gov/21204788