Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Phillip J. Iaquinta"'
Autor:
Haley Hieronymus, Phillip J. Iaquinta, John Wongvipat, Anuradha Gopalan, Rajmohan Murali, Ninghui Mao, Brett S. Carver, Charles L. Sawyers
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Although the locus at 3p13-14 is commonly deleted in prostate cancer, the identity of the potential driver genes is still unclear. Here, the authors, using a PTEN loss-driven prostate cancer mouse model, show that a multigenic FOXP1-SHQ1 deletion is
Externí odkaz:
https://doaj.org/article/836ceacd80084e6394c47fe1007f64e2
Autor:
Supreet Agarwal, Paul G. Hynes, Heather S. Tillman, Ross Lake, Wassim G. Abou-Kheir, Lei Fang, Orla M. Casey, Amir H. Ameri, Philip L. Martin, Juan Juan Yin, Phillip J. Iaquinta, Wouter R. Karthaus, Hans C. Clevers, Charles L. Sawyers, Kathleen Kelly
Publikováno v:
Cell Reports, Vol 13, Iss 10, Pp 2147-2158 (2015)
Primary prostate cancer almost always has a luminal phenotype. However, little is known about the stem/progenitor properties of transformed cells within tumors. Using the aggressive Pten/Tp53-null mouse model of prostate cancer, we show that two clas
Externí odkaz:
https://doaj.org/article/10f129a7fb434bc989882304f60a11d9
Autor:
Charles L. Sawyers, Simon N. Powell, Jayanta Chaudhuri, Maria Jasin, Michael J. Zelefsky, Peter T. Scardino, John Wongvipat, Haley Hieronymus, Anuradha Gopalan, Alexander G. Goglia, Sho Fujisawa, Neel P. Shah, Philip A. Watson, Yu Chen, Brett S. Carver, Deyou Zheng, Ling Cai, Wei-Feng Yen, Vivek K. Arora, Phillip J. Iaquinta, Daniel E. Spratt, Elizabeth M. Kass, Man X. Lee, Joel S. Parker, William R. Polkinghorn
Supplementary Figure S1 - PDF file 1194K, Gamma-H2AX foci and Comet assay normalized of LNCaP plus or minus androgen normalized to time 0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e77594a6f2297abd44d8b914566fc28
https://doi.org/10.1158/2159-8290.22529294.v1
https://doi.org/10.1158/2159-8290.22529294.v1
Autor:
Charles L. Sawyers, Simon N. Powell, Jayanta Chaudhuri, Maria Jasin, Michael J. Zelefsky, Peter T. Scardino, John Wongvipat, Haley Hieronymus, Anuradha Gopalan, Alexander G. Goglia, Sho Fujisawa, Neel P. Shah, Philip A. Watson, Yu Chen, Brett S. Carver, Deyou Zheng, Ling Cai, Wei-Feng Yen, Vivek K. Arora, Phillip J. Iaquinta, Daniel E. Spratt, Elizabeth M. Kass, Man X. Lee, Joel S. Parker, William R. Polkinghorn
Supplementary Table S2 - PDF file 250K, Defining AR-regulated DNA repair genes in LNCaP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25e9824254a57dbcbbfe87a6194f0ac0
https://doi.org/10.1158/2159-8290.22529276.v1
https://doi.org/10.1158/2159-8290.22529276.v1
Publikováno v:
Human Reproduction Update. 28:313-345
The pathways of gametogenesis encompass elaborate cellular specialization accompanied by precise partitioning of the genome content in order to produce fully matured spermatozoa and oocytes. Transcription factors are an important class of molecules t
Autor:
Patrick S. Sullivan, Michael G. Doran, Charles L. Sawyers, Ping Wang, Neel Shah, Phillip J. Iaquinta, Wassim Abida, Anna Patruno, Elizabeth V. Wasmuth, Nikolaus Schultz, John Wongvipat, Rohit Bose, Joshua Armenia, Wouter R. Karthaus, Yilin Zhao, Zeda Zhang, Deyou Zheng
Publikováno v:
Nature, vol 546, iss 7660
Bose, Rohit; Karthaus, Wouter R; Armenia, Joshua; Abida, Wassim; Iaquinta, Phillip J; Zhang, Zeda; et al.(2017). ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis.. Nature, 546(7660), 671-675. doi: 10.1038/nature22820. UCSF: Retrieved from: http://www.escholarship.org/uc/item/6z25z7n0
Bose, Rohit; Karthaus, Wouter R; Armenia, Joshua; Abida, Wassim; Iaquinta, Phillip J; Zhang, Zeda; et al.(2017). ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis.. Nature, 546(7660), 671-675. doi: 10.1038/nature22820. UCSF: Retrieved from: http://www.escholarship.org/uc/item/6z25z7n0
Half of all prostate cancers are caused by the TMPRSS2-ERG gene-fusion, which enables androgens to drive expression of the normally silent E26 transformation-specific (ETS) transcription factor ERG in prostate cells. Recent genomic landscape studies
Autor:
Charles L. Sawyers, Phillip J. Iaquinta, Greg Hannon, Abbas Nazir, Taslima F. Ishmael, Philip A. Watson, Kenneth Chang, Aura Agudelo Rivera, Yupu Liang, Kayla E. Lawrence, Jillian R. Love, John Wongvipat, Tejasveeta V. Nadkarni, Ling Cai, Eugine Lee
Publikováno v:
Cancer Research. 80:3430-3430
Regions of recurring chromosomal deletions have been annotated in clinical prostate cancer (PCa), but for many of them there is an incomplete understanding of their contributions to disease progression. From an in vivo shRNA enrichment screen of the
Autor:
Rajmohan Murali, Charles L. Sawyers, Ninghui Mao, Phillip J. Iaquinta, Anuradha Gopalan, John Wongvipat, Brett S. Carver, Haley Hieronymus
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
A multigenic locus at 3p13-14, spanning FOXP1 to SHQ1, is commonly deleted in prostate cancer and lost broadly in a range of cancers but has unknown significance to oncogenesis or prognosis. Here, we report that FOXP1-SHQ1 deletion cooperates with PT
Autor:
Charles L. Sawyers, Norman Sachs, Ruben van Boxtel, Jarno Drost, Catherine Dowling, Harry Begthel, Phillip J. Iaquinta, Ana Gracanin, Robert G.J. Vries, Edwin Cuppen, Hans Clevers, Yu Chen, Dong Gao, Wouter R. Karthaus, John Wongvipat
Publikováno v:
Cell, 159(1), 163-75. Elsevier B.V.
SummaryThe prostate gland consists of basal and luminal cells arranged as pseudostratified epithelium. In tissue recombination models, only basal cells reconstitute a complete prostate gland, yet murine lineage-tracing experiments show that luminal c
Autor:
Charles L. Sawyers, Phillip J. Iaquinta, Ping Chi, Dong Gao, Howard I. Scher, Shira Rockowitz, Yu Chen, Inna Sirota, Brett S. Carver, John Wongvipat, Shipra Shukla, Deyou Zheng, Tambudzai Shamu
Publikováno v:
Nature medicine
Studies of ETS-mediated prostate oncogenesis have been hampered by a lack of suitable experimental systems. Here we describe a new conditional mouse model that shows robust, homogenous ERG expression throughout the prostate. When combined with homozy