Výsledky vyhledávání - "Phillip J. Fiore"

Kiloscale Buchwald–Hartwig Amination: Optimized Coupling of Base-Sensitive 6-Bromoisoquinoline-1-carbonitrile with (S)-3-Amino-2-methylpropan-1-ol

Autor: Jotham Wadsworth Coe, Phillip J. Fiore, Ian Edmonds, Jeffrey B. Sperry, Wiglesworth Kristin, Eugene Lvovich Piatnitski Chekler, Jonathan Langille, David C. Boyles, Roberta Louise Dorow, David B. Damon

Publikováno v: Organic Process Research & Development. 18:1752-1758

This work describes the optimization and scale-up of a Buchwald–Hartwig amination reaction for the preparation of a pharmaceutical intermediate. This C–N bond formation is challenged by the use of a chiral primary amine, which both adds cost and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::470ba14d178fb0c8d303c2bfa1cd4ece
https://doi.org/10.1021/op5002319

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Development and Pilot-Scale Demonstration of a Process for Inhibitors of the HIV Nucleocapsid Protein, NCp7

Autor: Phillip J. Fiore, Walker Jonathan, and Timothy P. Puls

Publikováno v: Organic Process Research & Development. 2:151-156

A manufacturing process to prepare two antiretroviral agents that denature the HIV-1 nucleocapsid protein (NCp7) has been developed and demonstrated on a pilot scale. 2,2‘-Dithiobis(benzoyl chloride) (4), prepared from commercially available 2,2‘

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec8b1ba648b6f0111b0095a87293f647
https://doi.org/10.1021/op9701191

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Chemical Development of a Pilot Scale Process for the ACAT Inhibitor 2,6-Diisopropylphenyl [(2,4,6-Triisopropylphenyl)acetyl]sulfamate

Autor: Gary J. Dozeman, Phillip J. Fiore, and Timothy P. Puls, Walker Jonathan

Publikováno v: Organic Process Research & Development. 1:137-148

A manufacturing process to prepare the ACAT inhibitor 2,6-diisopropylphenyl [(2,4,6-triisopropylphenyl)acetyl]sulfamate (1; CI-1011) has been developed and successfully demonstrated on a pilot scale. Commercially available 1,3,5-triisopropylbenzene (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1524bd5da404387d73a705fdcbe13ee1
https://doi.org/10.1021/op9600419

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ChemInform Abstract: Chemical Development of a Pilot Scale Process for the ACAT Inhibitor 2, 6-Diisopropylphenyl ((2,4,6-Triisopropylphenyl)acetyl)sulfamate

Autor: T. P. Puls, Walker Jonathan, Phillip J. Fiore, G. J. Dozeman

Publikováno v: ChemInform. 28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b5f150c9f6b536a24fad712d26a39e4
https://doi.org/10.1002/chin.199738126

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ChemInform Abstract: Development and Pilot-Scale Demonstration of a Process for Inhibitors of the HIV Nucleocapsid Protein, NCp7

Autor: Phillip J. Fiore, Walker Jonathan, T. P. Puls

Publikováno v: ChemInform. 29

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3743338e2d415d8e3b9ed7d9a54d34f2
https://doi.org/10.1002/chin.199842127

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A Direct and Efficient Synthesis of 5′-Deoxy-2′, 3′

Autor: Phillip J. Fiore, James G. Davidson

Publikováno v: Nucleosides and Nucleotides. 10:1477-1483

A direct and efficient synthesis of 5′-deoxy-2′,3′-O-isopropylideneinosine, 7, from readily available inosine is described. An example of a potentially general synthesis of N -substituted-5′-deoxyadenosines from 7 is also described.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::997d34635924c6bc080e4a866befdd95
https://doi.org/10.1080/07328319108046676

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