Zobrazeno 1 - 10
of 255
pro vyhledávání: '"Phillip J, Stansfeld"'
Autor:
Peter Wotherspoon, Hannah Johnston, David J. Hardy, Rachel Holyfield, Soi Bui, Giedrė Ratkevičiūtė, Pooja Sridhar, Jonathan Colburn, Charlotte B. Wilson, Adam Colyer, Benjamin F. Cooper, Jack A. Bryant, Gareth W. Hughes, Phillip J. Stansfeld, Julien R. C. Bergeron, Timothy J. Knowles
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The Maintenance of Lipid Asymmetry (Mla) pathway is a multicomponent system found in all gram-negative bacteria that contributes to virulence, vesicle blebbing and preservation of the outer membrane barrier function. It acts by removing ecto
Externí odkaz:
https://doaj.org/article/b7c3efd6199f407a8b00be9ac32695d5
Autor:
Jan Böhning, Miles Graham, Suzanne C. Letham, Luke K. Davis, Ulrike Schulze, Phillip J. Stansfeld, Robin A. Corey, Philip Pearce, Abul K. Tarafder, Tanmay A. M. Bharat
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Inoviruses are filamentous phages infecting numerous prokaryotic phyla. Inoviruses can self-assemble into mesoscale structures with liquid-crystalline order, termed tactoids, which protect bacterial cells in Pseudomonas aeruginosa biofilms f
Externí odkaz:
https://doaj.org/article/6511d5149f124097b4448d6c2a9651f0
Autor:
T. Bertie Ansell, Wanling Song, Claire E. Coupland, Loic Carrique, Robin A. Corey, Anna L. Duncan, C. Keith Cassidy, Maxwell M. G. Geurts, Tim Rasmussen, Andrew B. Ward, Christian Siebold, Phillip J. Stansfeld, Mark S. P. Sansom
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Cryo-electron microscopy (cryo-EM) enables the determination of membrane protein structures in native-like environments. Characterising how membrane proteins interact with the surrounding membrane lipid environment is assisted by resolution
Externí odkaz:
https://doaj.org/article/cf3afb5f6f044bce9bcb06b11105b64c
LptM promotes oxidative maturation of the lipopolysaccharide translocon by substrate binding mimicry
Autor:
Yiying Yang, Haoxiang Chen, Robin A. Corey, Violette Morales, Yves Quentin, Carine Froment, Anne Caumont-Sarcos, Cécile Albenne, Odile Burlet-Schiltz, David Ranava, Phillip J. Stansfeld, Julien Marcoux, Raffaele Ieva
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Insertion of lipopolysaccharide (LPS) into the bacterial outer membrane (OM) is mediated by a druggable OM translocon consisting of a β-barrel membrane protein, LptD, and a lipoprotein, LptE. The β-barrel assembly machinery (BAM) assembles
Externí odkaz:
https://doaj.org/article/ed9b9dea67df414eaaab40bf034d319b
Autor:
Rie Nygaard, Chris L. B. Graham, Meagan Belcher Dufrisne, Jonathan D. Colburn, Joseph Pepe, Molly A. Hydorn, Silvia Corradi, Chelsea M. Brown, Khuram U. Ashraf, Owen N. Vickery, Nicholas S. Briggs, John J. Deering, Brian Kloss, Bruno Botta, Oliver B. Clarke, Linda Columbus, Jonathan Dworkin, Phillip J. Stansfeld, David I. Roper, Filippo Mancia
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Peptidoglycan (PG) is an essential structural component of the bacterial cell wall that is synthetized during cell division and elongation. PG forms an extracellular polymer crucial for cellular viability, the synthesis of which is the targe
Externí odkaz:
https://doaj.org/article/f8db36713a734cacbd61374a4c829bb4
Autor:
Michael F. Fuss, Jan-Philip Wieferig, Robin A. Corey, Yvonne Hellmich, Igor Tascón, Joana S. Sousa, Phillip J. Stansfeld, Janet Vonck, Inga Hänelt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Cyclic di-AMP is the only known essential second messenger in bacteria and archaea, regulating different proteins indispensable for numerous physiological processes. In particular, it controls various potassium and osmolyte transporters invo
Externí odkaz:
https://doaj.org/article/d7e604588b594a688deb0ddfbae8a895
Autor:
C. Keith Cassidy, Zhuan Qin, Thomas Frosio, Khoosheh Gosink, Zhengyi Yang, Mark S. P. Sansom, Phillip J. Stansfeld, John S. Parkinson, Peijun Zhang
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Motile bacteria employ conserved chemotaxis networks to detect chemical gradients in their surroundings and effectively regulate their locomotion, enabling the location of essential nutrients and other important biological niches. The sensor
Externí odkaz:
https://doaj.org/article/e150b6dfc911417aa1855dc8eac75765
Autor:
Emma C. Couves, Scott Gardner, Tomas B. Voisin, Jasmine K. Bickel, Phillip J. Stansfeld, Edward W. Tate, Doryen Bubeck
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
CD59 protects human cells from damage by the MAC immune pore. The authors show how CD59 inhibits MAC, by deflecting pore-forming β-hairpins of complement proteins. As well as how the membrane environment influences the role of CD59 in complement reg
Externí odkaz:
https://doaj.org/article/1d86c42b34e04084a69e7434c448c724
Autor:
Abraham O. Oluwole, Robin A. Corey, Chelsea M. Brown, Victor M. Hernández-Rocamora, Phillip J. Stansfeld, Waldemar Vollmer, Jani R. Bolla, Carol V. Robinson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Bacterial cell wall enzymes and their precursors are critical targets for antibiotic development. Here, the authors investigate several biosynthetic enzymes with their substrates and show that the passage of substrates and products in the pathway is
Externí odkaz:
https://doaj.org/article/a1a15d916c894fcdb85734251559a178
Autor:
Yoel A. Klug, Justin C. Deme, Robin A. Corey, Mike F. Renne, Phillip J. Stansfeld, Susan M. Lea, Pedro Carvalho
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Lipid droplet biogenesis is orchestrated by the conserved membrane protein Seipin via an unknown mechanism. Here, the authors use structural, biochemical and molecular dynamics simulation approaches to reveal the mechanism of lipid droplet formation
Externí odkaz:
https://doaj.org/article/3c961ba27c154e8598353be409285d56