Výsledky vyhledávání - "Phillip Harnish"

Telmisartan in the diabetic murine model of acute myocardial infarction: dual contrast manganese-enhanced and delayed enhancement MRI evaluation of the peri-infarct region

Autor: Phillip Harnish, Ildiko Toma, Phillip C. Yang, Paul J Kim, Dwight G. Nishimura, Michael V. McConnell, Rajesh Dash

Publikováno v: Cardiovascular Diabetology

Background A novel MRI technique, employing dual contrast manganese-enhanced MRI (MEMRI) and delayed enhancement MRI (DEMRI), can evaluate the physiologically unstable peri-infarct region. Dual contrast MEMRI–DEMRI enables comprehensive evaluation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d96d59dd74cbdd362e4764f4bb55eb77
https://doi.org/10.1186/s12933-016-0348-y

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Manganese‐Enhanced Magnetic Resonance Imaging Enables In Vivo Confirmation of Peri‐Infarct Restoration Following Stem Cell Therapy in a Porcine Ischemia–Reperfusion Model

Autor: Yuka Matsuura, Michael V. McConnell, Alan C. Yeung, Jennifer Lyons, Scott A. Metzler, Phillip C. Yang, Joseph C. Wu, Phillip Harnish, Paul J Kim, Xiaohu Ge, Ngan F. Huang, Cheryl Wong Po Foo, Fumiaki Ikeno, Rajesh Dash, Patricia K. Nguyen

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Background The exact mechanism of stem cell therapy in augmenting the function of ischemic cardiomyopathy is unclear. In this study, we hypothesized that increased viability of the peri‐infarct region ( PIR ) produces restorative benefits after ste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b3b9f87cc3aa210440838367571641
https://doi.org/10.1161/jaha.115.002044

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Manganese-Enhanced cardiac MRI (MEMRI) tracks long-term in vivo survival and restorative benefit of transplanted human Amnion-Derived Mesenchymal Stem Cells (hAMSC) after porcine ischemia-reperfusion injury

Publikováno v: Journal of Cardiovascular Magnetic Resonance, Vol 15, Iss Suppl 1, p O106 (2013)
Journal of Cardiovascular Magnetic Resonance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9aa3e8586fc8676cacc986b55d38ffa
https://doi.org/10.1186/1532-429x-15-s1-o106

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Direct Evaluation of Myocardial Viability and Stem Cell Engraftment Demonstrates Salvage of the Injured Myocardium

Autor: Helen M. Blau, Morteza Mahmoudi, Colin Holbrook, Paul J Kim, John Ramunas, Ildiko Toma, Nigel G. Kooreman, Scott A. Metzler, Xiaohu Ge, Yuka Matsuura, Phillip Harnish, Michael V. McConnell, Eric Rulifson, Phillip C. Yang

Publikováno v: Circulation Research. 116

Rationale: The mechanism of functional restoration by stem cell therapy remains poorly understood. Novel manganese-enhanced MRI and bioluminescence reporter gene imaging were applied to follow myocardial viability and cell engraftment, respectively.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce218aac2e2ed9c43e487c9654ca0ba0
https://doi.org/10.1161/circresaha.116.304668

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Safety, tolerance, and pharmacokinetics of iodixanol injection, a nonionic, isosmolar, hexa-iodinated contrast agent

Autor: Birthe Hougens Grynne, E Andrew, Harvey Fountaine, Phillip Harnish

Publikováno v: Academic Radiology. 3:S475-S484

Rationale and Objectives. A review of clinical-chemical parameters and tolerability of iodixanol is presented. Iodixanol is a newly developed dimeric, ratio 6 radiographic contrast medium formulated to be isotonic to plasma in all concentrations by t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef69ee18185ac92e34ef0e15c32f445
https://doi.org/10.1016/s1076-6332(05)80362-9

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Dual manganese-enhanced and delayed gadolinium-enhanced MRI detects myocardial border zone injury in a pig ischemia-reperfusion model

Autor: Rajesh Dash, Phillip Harnish, Jaehoon Chung, Michael V. McConnell, Annett Hahn-Windgassen, Tomohiko Teramoto, Todd J. Brinton, Jennifer Lyons, Fumiaki Ikeno, Robert C. Robbins, Mihoko V. Bennett, Phillip C. Yang, Yuka Matsuura, Alan C. Yeung

Publikováno v: Circulation. Cardiovascular imaging. 4(5)

Background— Gadolinium (Gd)-based delayed-enhancement MRI (DEMRI) identifies nonviable myocardium but is nonspecific and may overestimate nonviable territory. Manganese (Mn 2+ )-enhanced MRI (MEMRI) denotes specific Mn 2+ uptake into viable cardiom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c59ed05c88c24c66718e66b80b6c8139
https://pubmed.ncbi.nlm.nih.gov/21719779

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Manganese-enhanced MRI detects live human amnion-derived mesenchymal stem cells in vivo after transplantation and restoration of myocardial function in a pig ischemia-reperfusion injury model

Autor: Grace Do, Kaori Nakagawa, Shahriar Heidary, Jennifer Lyons, Fumiaki Ikeno, Phillip Harnish, Rajesh Dash, Ildiko Toma, Marie-Claude Parent, Phillip C. Yang, Robert C. Robbins, Justin Lam, Svetlana Lyalina, I-Ning E. Wang, Jaehoon Chung, Michael V. McConnell, Xiaohu Ge, Paul J Kim, Alan C. Yeung

Publikováno v: Journal of Cardiovascular Magnetic Resonance
Journal of Cardiovascular Magnetic Resonance, Vol 14, Iss Suppl 1, p P62 (2012)

Summary Human Amnion-derived Mesenchymal Stem Cells (hAMSCs) were transplanted into the infarct and periinfarct regions of a pig ischemia-reperfusion model. The hAMSC therapy improved cardiac systolic function post-MI, compared to control animals, an

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