Zobrazeno 1 - 10 of 60 pro vyhledávání: '"Phillip H. Pekala"'
1
Post-transcriptional Control of CCAAT/Enhancer-binding Protein β (C/EBPβ) Expression
Autor: Phillip H. Pekala, Vesna A. Karschner, Heath Jones, Joy Cherry
Publikováno v: Journal of Biological Chemistry. 283:30812-30820
In 3T3-L1 cells, HuR is constitutively expressed and prior to induction of differentiation localized predominantly to the nucleus. Within minutes of induction of differentiation, nuclear HuR binds to its target ligand mRNAs, and the complexes appear
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17e74127c457770e3f6d4802d285f8a2
https://doi.org/10.1074/jbc.m805659200
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3
HuR binds to a single site on the C/EBPβ mRNA of 3T3-L1 adipocytes
Autor: Carver M, Heath Jones, Phillip H. Pekala
Publikováno v: Biochemical and Biophysical Research Communications. 355:217-220
HuR is a ligand for nuclear mRNAs containing adenylate-uridylate rich elements in the 3'- untranslated region. Once bound to the mRNA HuR is recognized by adapter proteins which then facilitate nuclear export of the complex. In the cytosol HuR is tho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f516b9ce046741af0481ba6b4c1032d5
https://doi.org/10.1016/j.bbrc.2007.01.136
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4
The regulation of glucose transporter (GLUT1) expression by the RNA binding protein HuR
Autor: Ulus Atasoy, Kira R. Gantt, Phillip H. Pekala, Melissa Richardson, Vesna A. Karschner, Joy Cherry
Publikováno v: Journal of Cellular Biochemistry. 99:565-574
HuR is a ligand for nuclear mRNAs containing adenylate-uridylate-rich (ARE) elements in the 3'-untranslated region. Once bound to the mRNA, HuR is recognized by adapter proteins that then facilitate nuclear export of the complex. In the cytosol, HuR
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf1a73a249d26fbc09019a3c3c854856
https://doi.org/10.1002/jcb.20950
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5
GLUT4 repression in response to oxidative stress is associated with reciprocal alterations in C/EBP alpha and delta isoforms in 3T3-L1 adipocytes
Autor: Julia Kovsan, Assaf Rudich, Nava Bashan, Dorit Pessler-Cohen, Asnat Bloch-Damti, Phillip H. Pekala
Publikováno v: Archives of Physiology and Biochemistry. 112:3-12
Insulin responsiveness of adipocytes is acquired during normal adipogenesis, and is essential for maintaining whole-body insulin sensitivity. Differentiated adipocytes exposed to oxidative stress become insulin resistant, exhibiting decreased express
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0956086718aca6235770a8229d08c314
https://doi.org/10.1080/13813450500500399
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6
Interleukin 11 treatment alters the protein content of Gαi2 and adipogenic transcription factors in 3T3-L1 adipocytes
Autor: Raleigh Tenney, Phillip H. Pekala
Publikováno v: Cytokine. 27:1-6
Exposure of fully differentiated 3T3-L1 adipocytes to 5 nM interleukin 11 (IL-11) resulted in an increase (1.9+/-0.5 fold) in the protein content for the heterotrimeric G protein Galpha(i2). This G protein has been suggested to be involved in the con
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88a776ef3960ade16b973325468381a
https://doi.org/10.1016/j.cyto.2004.03.008
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8
Tumor Necrosis Factor-alpha-Induced Insulin Resistance in Adipocytes
Autor: Chen Qi, Phillip H. Pekala
Publikováno v: Proceedings of the Society for Experimental Biology and Medicine. 223:128-135
Recent studies examining the link between insulin resistance and the development of obesity and noninsulin-dependent diabetes mellitus are consistent with the involvement of tumor necrosis factor-alpha (TNF-alpha) as a central mediator. In insulin re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeacc6cf4ab7a0ffc2ff77dc203fb5b6
https://doi.org/10.1046/j.1525-1373.2000.22318.x
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9
The Influence of mRNA Stability on Glucose Transporter (GLUT1) Gene Expression
Autor: Phillip H. Pekala, Chen Qi
Publikováno v: Biochemical and Biophysical Research Communications. 263:265-269
One mechanism for modification of glucose transport activity occurs through regulation of the cellular content of transporter protein by alteration of transcript stability. Regulated mRNA decay has been shown to play an important role in control of p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e3e680a132549a904efd03cebf99d6
https://doi.org/10.1006/bbrc.1999.1328
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10
Tumor necrosis factor-? initiated signal transduction in 3T3-L1 adipocytes
Autor: Kelle D. Phelps, Phillip H. Pekala, Renu G. Jain
Publikováno v: Journal of Cellular Physiology. 179:58-66
Examination of the ability of tumor necrosis factor-alpha (TNF) to activate both the p44/42 and p38 MAP kinase cascades in fully differentiated 3T3-L1 adipocytes indicated a rapid MEK1/2-dependent activation of p44/42 MAP kinase. Use of the MEK1/2 in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::adc92ec98a8409156e81cffc1cad4f49
https://doi.org/10.1002/(sici)1097-4652(199904)179:1<58::aid-jcp8>3.0.co
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