Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Phillip H Beske"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 9 (2015)
Botulinum neurotoxins (BoNTs) are extremely potent toxins that specifically cleave SNARE proteins in peripheral synapses, preventing neurotransmitter release. Neuronal responses to BoNT intoxication are traditionally studied by quantifying SNARE prot
Externí odkaz:
https://doaj.org/article/2404cc393d6749bcbb25b58fa7452d99
Autor:
Ian M Gut, Phillip H Beske, Kyle S Hubbard, Megan E Lyman, Tracey A Hamilton, Patrick M McNutt
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64423 (2013)
Glutamate receptor (GluR)-mediated neurotoxicity is implicated in a variety of disorders ranging from ischemia to neural degeneration. Under conditions of elevated glutamate, the excessive activation of GluRs causes internalization of pathologic leve
Externí odkaz:
https://doaj.org/article/10c9f2857c4143b38d2dc10ef05e50af
Autor:
David T. Yeung, Jill A. Harvilchuck, Gennady E. Platoff, Christina M. Wilhelm, Phillip H Beske
Publikováno v:
Mil Med
Introduction While exposure to sulfur mustard (SM) is commonly associated with the production of vesicating dermal, ocular, and respiratory injuries, systemic damage to bone marrow and lymphatic tissue can decrease critical immune cell populations le
Autor:
Darrell A. Jackson, Fanny Astruc-Diaz, Lindsay M Achzet, Phillip H. Beske, Travis T. Denton, Nicholas R. Natale
Publikováno v:
Pharmaceutics
Volume 13
Issue 5
Pharmaceutics, Vol 13, Iss 636, p 636 (2021)
Volume 13
Issue 5
Pharmaceutics, Vol 13, Iss 636, p 636 (2021)
Strokes remain one of the leading causes of disability within the United States. Despite an enormous amount of research effort within the scientific community, very few therapeutics are available for stroke patients. Cytotoxic accumulation of intrace
Publikováno v:
Journal of Pharmaceutics and Therapeutics. 4:170-181
Most 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propanoic acid receptors (AMPARs) expressed on adult hippocampal pyramidal neurons contain the edited form of GluA2 (Q607R) and are thus impermeable to Ca2+/Zn2+ entry. Following ischemic injury, thes
Autor:
Celinia A. Ondeck, John H. McDonough, Cherish E. Ardinger, Parker B. Dubée, Kari M. Haines, Paige M. Bodner, Patrick M. McNutt, Dominique L. Nguyen, Phillip H. Beske, Margaret R. Eisen, Hilary S. McCarren, Cary L. Honnold, Antonia N. Santoro, Emily N. Dunn
Publikováno v:
Epilepsy Res
Purpose To develop and characterize a mouse model of spontaneous recurrent seizures following nerve agent-induced status epilepticus (SE) and test the efficacy of existing antiepileptic drugs. Methods SE was induced in telemeterized male C57Bl6/J mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e625b5a11cf0b98c8cab8c41f7818e91
https://europepmc.org/articles/PMC7156324/
https://europepmc.org/articles/PMC7156324/
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports
Scientific Reports
Botulinum neurotoxins (BoNTs) are highly potent toxins that cleave neuronal SNARE proteins required for neurotransmission, causing flaccid paralysis and death by asphyxiation. Currently, there are no clinical treatments to delay or reverse BoNT-induc
Publikováno v:
Journal of Neurochemistry. 132:504-519
A hallmark of ischemic/reperfusion injury is a change in subunit composition of synaptic 2-amino-3-(3-hydroxy-5-methylisoazol-4-yl)propionic acid receptors (AMPARs). This change in AMPAR subunit composition leads to an increase in surface expression
Publikováno v:
Toxicon : official journal of the International Society on Toxinology. 147
Botulinum neurotoxins (BoNTs) are exceedingly potent neurological poisons that block cholinergic release in the peripheral nervous system and cause death by asphyxiation. While post-exposure prophylaxis can effectively eliminate toxin in the bloodstr
Autor:
Jean Mukherjee, Edwin J. Vazquez-Cintron, Philip A. Band, Suzanne R. Kalb, Phillip H. Beske, Bao Q. Tran, Christopher A. Angeles, Elliot J. Glotfelty, Konstantin Ichtchenko, Charles B. Shoemaker, Luis Tenezaca, Jonathan M. Oyler, Aurelia Syngkon, Patrick M. McNutt
Publikováno v:
Scientific Reports
Botulinum neurotoxin (BoNT) binds to and internalizes its light chain into presynaptic compartments with exquisite specificity. While the native toxin is extremely lethal, bioengineering of BoNT has the potential to eliminate toxicity without disrupt