Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Phillip H, Koeffler"'
2
Non-malignant epithelial cells preferentially proliferate from nasopharyngeal carcinoma biopsy cultured under conditionally reprogrammed conditions
Autor: Lin Tao, Yanan Lu, Fenggang Yu, Hironori Yoshiyama, Yan-Yi Jiang, Fredrik Petersson, Lingzhi Wang, De-Chen Lin, Phillip H Koeffler, Boon Cher Goh, Kwok Seng Loh
Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
Scientific Reports
Nasopharyngeal carcinoma (NPC) is an invasive cancer with particularly high incidence in Southern China and Southeast Asia. The study of NPC is greatly hampered by the lack of reliable cell lines due to the loss of EBV genome and HeLa cell contaminat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa774b90e360570e28f4eab4d5206d5
https://doi.org/10.1038/s41598-017-17628-z
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3
Oncogenic function and prognostic significance of protein tyrosine phosphatase PRL-1 in hepatocellular carcinoma
Autor: Jian Sun, Phillip H Koeffler, Kang Xu, Shaowen Jin, Junyao Xu, De-Chen Lin, Jie Wang, Zhonghua Chu, Dong Yin, Kaimei Wang
Publikováno v: Oncotarget, vol 5, iss 11
Oncotarget
// Shaowen Jin 1,2 , Kaimei Wang 3 , Kang Xu 1 , Junyao Xu 1 , Jian Sun 1 , Zhonghua Chu 4 , Dechen Lin 5 , Phillip H. Koeffler 5 , Jie Wang 1 and Dong Yin 2 1 Department of Hepatobiliary Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8cefeeef426839e06981be9a5187d56
https://doi.org/10.18632/oncotarget.1986
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4
Abstract 1524: BCL6 modulates the TP53 and STAT pathways in glioma
Autor: Phillip H Koeffler, Henry Yang, Beng Ti Ang, Yuk Kien Chong, Anand Mayakonda, William H. Yong, Liang Xu, Markus Müschen, Lynnette Koh, Ngan B. Doan, Edwin Sandanaraj, Carol Tang, De-Chen Lin, Vikas Madan, Ye Chen, Joshua J. Breunig, Jonathan W. Said, Marina Dutra-Clarke
Publikováno v: Cancer Research. 77:1524-1524
Glioblastoma multiforme (GBM) remains the most aggressive brain malignancy with little improvement in prognosis or therapy for decades. Recently, we identified BCL6, also known as ZBTB27, to be a novel oncogene in GBM. In this study, we performed IHC
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::435900445371b48efd2de982d86b8392
https://doi.org/10.1158/1538-7445.am2017-1524
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5
Abstract 4944: Identification of B-cell lymphoma 6 as a novel therapeutic target in glioblastoma
Autor: Liang Xu, Ye Chen, De-Chen Lin, Anand Mayakonda Thippeswamy, Markus Müschen, Henry Yang, Phillip H Koeffler, Masaharu Hazawa
Publikováno v: Cancer Research. 75:4944-4944
Background Glioblastoma multiforme (GBM) is one of the most aggressive cancers in humans. Identification and characterization of the GBM-promoting factors is imperative for the development of novel and effective clinical interventions. We recently di
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf067d00c9506845f7b6b3751fc4f7ae
https://doi.org/10.1158/1538-7445.am2015-4944
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6
Antibody-mediated transduction of p53 selectively kills cancer cells
Autor: Richard H, Weisbart, James E, Hansen, Grace, Chan, Rika, Wakelin, Sophia S, Chang, Emil, Heinze, Carl W, Miller, Phillip H, Koeffler, Fusheng, Yang, Greg M, Cole, Yoon S, Min, Robert N, Nishimura
Publikováno v: International journal of oncology. 25(6)
Some human cancers are caused by functional defects in p53 that are restored by gene therapy with wild-type p53. To circumvent the use of viral vectors, we reconstituted cancer cell lines with p53 by protein transduction. A fusion protein was produce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::80951d9c2185770d59e7b4ce5d4804c6
https://pubmed.ncbi.nlm.nih.gov/15547728
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7
Construction and expression of a bispecific single-chain antibody that penetrates mutant p53 colon cancer cells and binds p53
Autor: Richard H, Weisbart, Rika, Wakelin, Grace, Chan, Carl W, Miller, Phillip H, Koeffler
Publikováno v: International journal of oncology. 25(4)
A bispecific, single-chain antibody Fv fragment (Bs-scFv) was constructed from a single-chain Fv fragment of mAb 3E10 that penetrates living cells and localizes in the nucleus, and a single-chain Fv fragment of a non-penetrating antibody, mAb PAb421
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::07ff37bc47417b10dacc3ae6bf0649e2
https://pubmed.ncbi.nlm.nih.gov/15375563
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8
Inactivation of Pre-B Cell Receptor-Mediated Tumor Suppression by Aberrant Splicing in Ph+ Acute Lymphoblastic Leukemia
Autor: Mieke Sprangers, Hassan Jumaa, Markus Müschen, Wolf-Karsten Hofmann, Phillip H Koeffler, Rahul Nahar, Giovanni Martinelli, Daniel Nowak, Lars Klemm, Cihangir Duy
Publikováno v: Blood. 114:579-579
Abstract 579 The pre-B cell receptor instructs differentiation of normal pre-B cells and functions as a tumor suppressor in pre-B acute lymphoblastic leukemia (ALL). Its function is impaired in virtually all cases of pre-B ALL carrying the Philadelph
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04abb501078af729b16cd1066287855c
https://doi.org/10.1182/blood.v114.22.579.579
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9
Adaptor Protein Lnk Binds to JAK3 and Negatively Regulates a Mutant Activating Allele Associated with Megakaryocytic Leukemia
Autor: Maya Koren-Michowitz, Phillip H Koeffler, Daniel Nowak, Sigal Gery
Publikováno v: Blood. 114:5044-5044
Abstract 5044 The adaptor protein Lnk is known to associate with hematopoietic cytokine receptors such as cKIT, MPL and PDGFR, as well as, non-receptor tyrosine kinases such as JAK2, and is considered to have an inhibitory effect on these signaling p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e18e5b7185e1f42b8a0c198e1180ce2f
https://doi.org/10.1182/blood.v114.22.5044.5044
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10
Frequent in Vivo redundancy of C/EBPβ and C/EBPε during Myeloid Development
Autor: Phillip H Koeffler, Adrian F Gombart, C. Müller-Tidow, Gay M. Crooks, Ann George, Daniel Nowak, Sam Abbassi, Tadayuki Akagi, Nils Heinrich Thoennissen
Publikováno v: Blood. 112:2440-2440
CCAAT/enhancer binding protein (C/EBP) transcription factors are involved in a variety of cellular responses including proliferation and differentiation. Although C/EBPβ and C/EBPε are believed to be most important for macrophage and granulocyte ac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e9acde91cae91470dcb1b75092056d10
https://doi.org/10.1182/blood.v112.11.2440.2440
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