Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Phillip G. Pierce"'
Autor:
Michael J. Hoy, Eunchong Park, Hyunji Lee, Won Young Lim, D. Christopher Cole, Nicholas D. DeBouver, Benjamin G. Bobay, Phillip G. Pierce, David Fox, Maria Ciofani, Praveen R. Juvvadi, William Steinbach, Jiyong Hong, Joseph Heitman
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Calcineurin is an essential virulence factor that is conserved across human fungal pathogens, including Cryptococcus neoformans, Aspergillus fumigatus, and Candida albicans. Although an excellent target for antifungal drug development, the s
Externí odkaz:
https://doaj.org/article/117f01418524456e8457bbd3d23cdecf
Autor:
Jacqueline M. Leung, Eiji Nagayasu, Yu-Chen Hwang, Jun Liu, Phillip G. Pierce, Isabelle Q. Phan, Robin A. Prentice, John M. Murray, Ke Hu
Publikováno v:
BMC Molecular and Cell Biology, Vol 21, Iss 1, Pp 1-25 (2020)
Abstract Background TgDCX is a doublecortin-domain protein associated with the conoid fibers, a set of strongly curved non-tubular tubulin-polymers in Toxoplasma. TgDCX deletion impairs conoid structure and parasite invasion. TgDCX contains two tubul
Externí odkaz:
https://doaj.org/article/89cafe90b9b541cfbac876409781982f
Autor:
Jua Iwasaki, Donald D. Lorimer, Mirella Vivoli-Vega, Emily A. Kibble, Christopher S. Peacock, Jan Abendroth, Stephen J. Mayclin, David M. Dranow, Phillip G. Pierce, David Fox, Maria Lewis, Nicole M. Bzdyl, Sofie S. Kristensen, Timothy J. J. Inglis, Charlene M. Kahler, Charles S. Bond, Anja Hasenkopf, Florian Seufert, Jens Schmitz, Laura E. Marshall, Andrew E. Scott, Isobel H. Norville, Peter J. Myler, Ulrike Holzgrabe, Nicholas J. Harmer, Mitali Sarkar-Tyson
Publikováno v:
Journal of Antimicrobial Chemotherapy. 77:1625-1634
Background The macrophage infectivity potentiator (Mip) protein, which belongs to the immunophilin superfamily, is a peptidyl-prolyl cis/trans isomerase (PPIase) enzyme. Mip has been shown to be important for virulence in a wide range of pathogenic m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ca13736e17f6f376896275651f4a70
https://doi.org/10.1093/jac/dkac065
https://doi.org/10.1093/jac/dkac065
Autor:
Michael J. Hoy, Eunchong Park, Hyunji Lee, Won Young Lim, D. Christopher Cole, Nicholas D. DeBouver, Benjamin G. Bobay, Phillip G. Pierce, David Fox, Maria Ciofani, Praveen R. Juvvadi, William Steinbach, Jiyong Hong, Joseph Heitman
Publikováno v:
mBio. 13
Due to rising rates of antifungal drug resistance and a limited armamentarium of antifungal treatments, there is a paramount need for novel antifungal drugs to treat systemic fungal infections. Calcineurin has been established as an essential and con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89d5e3691f424b12df939e277bf0aabc
https://doi.org/10.1128/mbio.01049-22
https://doi.org/10.1128/mbio.01049-22
Autor:
Ke Hu, John M. Murray, Yu Chen Hwang, Isabelle Q. Phan, Robin A. Prentice, Phillip G. Pierce, Jacqueline M. Leung, Eiji Nagayasu, Jun Liu
Publikováno v:
BMC Molecular and Cell Biology
BMC Molecular and Cell Biology, Vol 21, Iss 1, Pp 1-25 (2020)
BMC Molecular and Cell Biology, Vol 21, Iss 1, Pp 1-25 (2020)
Background TgDCX is a doublecortin-domain protein associated with the conoid fibers, a set of strongly curved non-tubular tubulin-polymers in Toxoplasma. TgDCX deletion impairs conoid structure and parasite invasion. TgDCX contains two tubulin-bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9897e81840b237b7fe66c8933c9ba24c
https://doi.org/10.1186/s12860-020-0249-5
https://doi.org/10.1186/s12860-020-0249-5
Autor:
Stephen N. Hewitt, Darren W. Begley, R. Meganathan, Hannah S. Udell, Gashaw M. Goshu, Phillip G. Pierce, Peter J. Myler, Joy M. Bain, Debarati Ghose, Timothy J. Hagen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5699-5704
The fragment FOL7185 (compound 17) was found to be a hit against IspD and IspE enzymes isolated from bacteria, and a series of analogs containing the pyrazolopyrimidine core were synthesized. The majority of these compounds inhibited the growth of Bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3aafb3677fc49ebac81975bdeb46c84
https://doi.org/10.1016/j.bmcl.2015.10.096
https://doi.org/10.1016/j.bmcl.2015.10.096
Autor:
Stephen J. Mayclin, Thomas E. Edwards, Amy Sullivan, Bart L. Staker, Isabelle Q. H. Phan, Darren W. Begley, Anna Gardberg, Vasilios M. Marathias, Jan Abendroth, Peter J. Myler, Donald D. Lorimer, Daniel H. Haft, Phillip G. Pierce
Publikováno v:
Scientific Reports
During human infection, Mycobacterium tuberculosis (Mtb) survives the normally bacteriocidal phagosome of macrophages. Mtb and related species may be able to combat this harsh acidic environment which contains reactive oxygen species due to the mycob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c390665959084ea382b4f84406073d03
Publikováno v:
Current Protocols in Chemical Biology
Fragment screening by saturation transfer difference nuclear magnetic resonance (STD-NMR) is a robust method for identifying small molecule binders and is well suited to a broad set of biological targets. STD-NMR is exquisitely sensitive for detectin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c936b15aa2708bf9ab644941b0bf5391
https://doi.org/10.1002/9780470559277.ch130118
https://doi.org/10.1002/9780470559277.ch130118
Autor:
Thomas E. Edwards, Mitali Sarkar-Tyson, Donald D. Lorimer, Bart L. Staker, Nicholas J. Harmer, Dominic C. Jenner, Muigai Muruthi, Jan Abendroth, Kris Safford, Amy C. Raymond, Vanessa Anderson, Ulrike Holzgrabe, Robin Stacy, Spencer O. Moen, Darren W. Begley, David A. Fox, Isobel H. Norville, Christina Juli, Phillip G. Pierce, Peter J. Myler, Kateri Atkins, Steve R. Barnes
Publikováno v:
Antimicrobial agents and chemotherapy. 58(3)
Macrophage infectivity potentiators (Mips) are immunophilin proteins and essential virulence factors for a range of pathogenic organisms. We applied a structural biology approach to characterize a Mip from Burkholderia pseudomallei (BpML1), the causa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3704d2334560e4ff73567a7faa6f4c
https://pubmed.ncbi.nlm.nih.gov/24366729
https://pubmed.ncbi.nlm.nih.gov/24366729