Výsledky vyhledávání - "Phillip F. Pratt"

668. Clinical Spectrum of Powassan Virus Infection in Patients Presenting with Suspected Acute Tick-Borne Illness From a Lyme-Endemic Focus in the Midwest

Autor: Sue C. Kehl, Phillip F. Pratt, Steven M. Callister, Angela M. Thomm, Dean A. Jobe, Konstance K. Knox, Ziyan Yin, Soyoung Kim

Publikováno v: Open Forum Infectious Diseases

Background Powassan virus (POWV) is the North American member of the tick-borne encephalitis complex of viruses. The potential for concurrent transmission with other tick-borne pathogens, particularly the Lyme disease agent Borrelia burgdorferi, is u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f34494f4b1be9d94e12bf4338a8dc3ee
http://europepmc.org/articles/PMC6255635

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Endothelial–cardiomyocyte crosstalk enhances pharmacological cardioprotection

Autor: David C. Warltier, Ines Baotic, Maria Muravyeva, Martin Bienengraeber, Anna K. Brzezinska, Thorsten M. Leucker, Judy R. Kersten, Dorothee Weihrauch, Phillip F. Pratt

Publikováno v: Journal of Molecular and Cellular Cardiology. 51:803-811

Endothelial cells (EC) serve a paracrine function to enhance signaling in cardiomyocytes (CM), and conversely, CM secrete factors that impact EC function. Understanding how EC interact with CM may be critically important in the context of ischemia-re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9df252778e958f98d34cc58afdbfbe
https://doi.org/10.1016/j.yjmcc.2011.06.026

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Decreased tetrahydrobiopterin and disrupted association of Hsp90 with eNOS by hyperglycemia impair myocardial ischemic preconditioning

Autor: Jianhai Du, Zhi-Dong Ge, David C. Warltier, Anna K. Brzezinska, Thorsten M. Leucker, Nikolina Vladic, Phillip F. Pratt, Yang Shi, Judy R. Kersten

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 301:H2130-H2139

Cardioprotection by ischemic preconditioning (IPC) is impaired during hyperglycemia, but the mechanisms underlying this phenomenon are poorly understood. This study investigated the role of hyperglycemia to adversely modulate tetrahydrobiopterin (BH4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c572f242ec4eaf565c2420a9795193
https://doi.org/10.1152/ajpheart.01078.2010

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Cigarette smoking impairs Na+-K+-ATPase activity in the human coronary microcirculation

Autor: David D. Gutterman, Phillip F. Pratt, Hiroto Miura, Kazuyoshi Toyama

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 300:H109-H117

The extracellular K+ concentration ([K+]o) has been proposed to link cardiac metabolism with coronary perfusion and arrhythmogenesis, particularly during ischemia. Several animal studies have also supported K+ as an EDHF that activates Na+-K+-ATPase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e761127f5464d028c793403ebda017d
https://doi.org/10.1152/ajpheart.00237.2010

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Isoflurane protects cardiomyocytes and mitochondria by immediate and cytosol-independent action at reperfusion

Autor: David C. Warltier, Danijel Pravdic, Yasushi Mio, Filip Sedlic, Phillip F. Pratt, Zeljko J. Bosnjak, Martin Bienengraeber

Publikováno v: British Journal of Pharmacology. 160:220-232

Background and purpose: The volatile anaesthetic isoflurane protects the heart from ischaemia and reperfusion (I/R) injury when applied at the onset of reperfusion [anaesthetic postconditioning (APoC)]. However, the mechanism of APoC-mediated protect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0cd3589a9423ced86e82251a5cc5e341
https://doi.org/10.1111/j.1476-5381.2010.00698.x

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Isoflurane Postconditioning Protects against Reperfusion Injury by Preventing Mitochondrial Permeability Transition by an Endothelial Nitric Oxide Synthase–dependent Mechanism

Autor: Zhi-Dong Ge, David C. Warltier, Garrett J. Gross, John A. Auchampach, Martin Bienengraeber, Phillip F. Pratt, Judy R. Kersten, Danijel Pravdic

Publikováno v: Anesthesiology. 112:73-85

Background The role of endothelial nitric oxide synthase (eNOS) in isoflurane postconditioning (IsoPC)-elicited cardioprotection is poorly understood. The authors addressed this issue using eNOS mice. Methods In vivo or Langendorff-perfused mouse hea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6499d4ef568e4c87415540e577b8e049
https://doi.org/10.1097/aln.0b013e3181c4a607

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Enhancement of nitric oxide release from nitrosyl hemoglobin and nitrosyl myoglobin by red/near infrared radiation: Potential role in cardioprotection

Autor: David C. Warltier, Phillip F. Pratt, Nicole L. Lohr, Agnes Keszler, Neil Hogg, Martin Bienengraber

Publikováno v: Journal of molecular and cellular cardiology

Nitric oxide is an important messenger in numerous biological processes, such as angiogenesis, hypoxic vasodilation, and cardioprotection. Although nitric oxide synthases (NOS) produce the bulk of NO, there is increasing interest in NOS independent g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2511d0078637aee5300d2effb41e9541
https://doi.org/10.1016/j.yjmcc.2009.03.009

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The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans

Autor: James E. Melvin, Ossama A. Hatoum, Heike Wulff, Kazuyoshi Toyama, Takashi Saito, David L. Mattson, Philippe Azam, Girija Raman, David R. Harder, Hiroto Miura, David D. Gutterman, Phillip F. Pratt, K. George Chandy, Satarupa Das, Yoshimasa Fujiwara

Publikováno v: Journal of Clinical Investigation. 118:3025-3037

Atherosclerosis remains a major cause of death in the developed world despite the success of therapies that lower cholesterol and BP. The intermediate-conductance calcium-activated potassium channel KCa3.1 is expressed in multiple cell types implicat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7433c099fc635eb978b4230723610ace
https://doi.org/10.1172/jci30836

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Inhibition of Glycogen Synthase Kinase or the Apoptotic Protein p53 Lowers the Threshold of Helium Cardioprotection In Vivo: The Role of Mitochondrial Permeability Transition

Autor: John G. Krolikowski, Phillip F. Pratt, David C. Warltier, Dorothee Weihrauch, Julien Amour, Yon Hee Shim, Paul S. Pagel

Publikováno v: Anesthesia & Analgesia. 107:769-775

Prosurvival signaling kinases inhibit glycogen synthase kinase-3beta (GSK-3beta) activity and stimulate apoptotic protein p53 degradation. Helium produces cardioprotection by activating prosurvival kinases, but whether GSK and p53 inhibition mediate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ff6d3729a285dc121d72987cc7bd5a
https://doi.org/10.1213/ane.0b013e3181815b84

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