Výsledky vyhledávání - "Phillip Dan Cook"

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Autor: Gopal B. Inamati, George Minasov, Martin Egli, Valentina Tereshko, Muthiah Manoharan, Marianna Teplova, Phillip Dan Cook

Publikováno v: Nature Structural Biology. 6:535-539

2'-O-(2-Methoxyethyl)-RNA (MOE-RNA) is a nucleic acid analog with promising features for antisense applications. Compared with phosphorothioate DNA (PS-DNA), the MOE modification offers improved nuclease resistance, enhanced RNA affinity, improved ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b76c545b2010ed0f535fe23b180bdecf
https://doi.org/10.1038/9304

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Discovery of Novel Pyridinopolyamines with Potent Antimicrobial Activity: Deconvolution of Mixtures Synthesized by Solution-Phase Combinatorial Chemistry

Autor: Phillip Dan Cook, Becky D. Haly, Haoyun An

Publikováno v: Journal of Medicinal Chemistry. 41:706-716

A 1638-member pyridinopolyamine library, consisting of 13 sublibraries of 126 members prepared by a solution-phase approach, was completely deconvoluted from orthogonally protected intermediates by a combination of iterative and positional scanning p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4332f720966e97e16c183620781f9dec
https://doi.org/10.1021/jm970598u

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General preparative synthesis of 2′-O-methylpyrimidine ribonucleosides

Autor: Robert S. Andrews, O. L. Acevedo, Bruce S. Ross, Robert H. Springer, Guillermo Vasquez, Phillip Dan Cook

Publikováno v: Journal of Heterocyclic Chemistry. 31:765-769

A convergent and general approach to synthesizing 2′-O-Methylpyrimidine ribonucleosides 4a-e, 6,7 on a multigram scale is described which begins with an improved procedure for making larger quantities of 2-O-methyl-1,3,5-tri-O-benzoyl-α-D-ribose.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ff112a7d58fec992c2777345b279c2d
https://doi.org/10.1002/jhet.5570310412

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Oligodeoxynucleotides containing 2'-O-modified adenosine: Synthesis and effects on stability of DNA:RNA duplexes

Autor: Susan M. Freier, Lendell L. Cummins, M Zounes, Elena A. Lesnik, Phillip Dan Cook, Andrew Mamoto Kawasaki, Charles J. Guinosso, David J. Ecker, Henri Sasmor

Publikováno v: Biochemistry. 32:7832-7838

Hybridization thermodynamics were compared for oligonucleotide sequences containing 2'-fluoro dA, 2'-O-methyl A, 2'-O-ethyl A, 2'-O-propyl A, 2'-O-butyl A, 2'-O-pentyl A, 2'-O-nonyl A, 2'-O-allyl A, and 2'-O-benzyl A in place of deoxyadenosine. Altho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0624ee5c3e6dbda89bbe1a84779874ee
https://doi.org/10.1021/bi00081a031

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Evaluation of 2‘-modified oligonucleotides containing 2‘-deoxy gaps as antisense inhibitors of gene expression

Autor: Susan M. Freier, Phillip Dan Cook, Daniel Peter Claude Mcgee, Brett P. Monia, Andrew Mamoro Kawasaki, Elena A. Lesnik, Carolyn Gonzalez, Walt F. Lima, Charles J. Guinosso

Publikováno v: Journal of Biological Chemistry. 268:14514-14522

We have used a previously described 17-mer phosphorothioate (Monia, B.P., Johnston, J.F., Ecker, D. J., Zounes, M.A., Lima, W.F., and Freier, S.M. (1992) J. Biol. Chem. 267, 19954-19962) for structure-function analysis of 2'-sugar modifications inclu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d9e7515bf39eeec59c6b1845589d165
https://doi.org/10.1016/s0021-9258(19)85268-7

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