Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Phillip D. Holler"'
Autor:
David M. Ornitz, Phillip D. Holler, Oh Sang Kwon, Zhikun Zhang, George Cotsarelis, Maksim V. Plikus, Arben Nace, Sarah E. Millar, Xiaohong Zhang, Mayumi Ito, Sheena Baratono, Fen Wang, Michelle Spata, Chang D Kim, Elsa Treffeisen, Zaixin Yang
Publikováno v:
Nature Medicine. 19:916-923
Understanding molecular mechanisms for regeneration of hair follicles provides new opportunities for developing treatments for hair loss and other skin disorders. Here we show that fibroblast growth factor 9 (Fgf9), initially secreted by γδ T cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f547421596d3c0583d754bc7b3923c9
https://doi.org/10.1038/nm.3181
https://doi.org/10.1038/nm.3181
Autor:
Wenyu Jiang, Phillip D. Holler, Diane Mathis, Molly Bogue, Markus Feuerer, Ansuman T. Satpathy, Christopher L. Campbell, Christophe Benoist
Publikováno v:
Proceedings of the National Academy of Sciences. 104:18181-18186
FoxP3 + CD4 + regulatory T cells (Tregs) play a key role in the maintenance of peripheral self-tolerance, and it has been suggested that diabetes-susceptible nonobese diabetic (NOD) mice are defective in the generation and numbers of Tregs. We found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4f262dbfd96b159b6f533a52d8ce218
https://doi.org/10.1073/pnas.0708899104
https://doi.org/10.1073/pnas.0708899104
Publikováno v:
Proceedings of the National Academy of Sciences. 103:1822-1827
Differences in T cell receptor (TCR) signaling initiated by interactions among TCRs, coreceptors, and self-peptide–MHC complexes determine the outcome of CD4 versus CD8 lineage of T cell differentiation. The H-2Ldand Kbm3alloreactive 2C TCR is posi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f179edafac80535cbfbee40f5be647
https://doi.org/10.1073/pnas.0510561103
https://doi.org/10.1073/pnas.0510561103
Autor:
David M. Kranz, Phillip D. Holler
Publikováno v:
Molecular Immunology. 40:1027-1031
Based on findings with the T cell receptor from mouse CTL clone 2C, and other TCRs, we propose a model that could account for degeneracy of T cell recognition. This "conformer model" holds that a single TCR exists in multiple conformations that are i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c1974fe97c4f925ac02d82b3a3efe8
https://doi.org/10.1016/j.molimm.2003.11.013
https://doi.org/10.1016/j.molimm.2003.11.013
Publikováno v:
Gene Therapy. 10:2067-2073
The potential of genetic immunization has been acknowledged for almost a decade, but disappointing immunogenicity in humans has delayed its introduction into the clinical arena. To try to increase the potency of genetic immunization, we and others ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd54285eee760cd895f77d34a83174f6
https://doi.org/10.1038/sj.gt.3302115
https://doi.org/10.1038/sj.gt.3302115
Publikováno v:
Nature Immunology. 4:55-62
T cells with high-affinity T cell receptors (TCRs) for a foreign peptide-major histocompatibility complex (pMHC) appear to be negatively selected, even though they have never seen the foreign antigen. To examine how this process operates, we used in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f455f79949dafb607badef9f95ae397
https://doi.org/10.1038/ni863
https://doi.org/10.1038/ni863
Autor:
Eric V. Shusta, David M. Kranz, Philmore O. Holman, Sean O'Herrin, Phillip D. Holler, K. Dane Wittrup
Publikováno v:
Proceedings of the National Academy of Sciences. 97:5387-5392
T cell receptors (TCRs) exhibit genetic and structural diversity similar to antibodies, but they have binding affinities that are several orders of magnitude lower. It has been suggested that TCRs undergo selectionin vivoto maintain lower affinities.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::698eb16ac9076f6b8aac431acd469b1f
https://doi.org/10.1073/pnas.080078297
https://doi.org/10.1073/pnas.080078297
Autor:
Edward J. Roy, David M. Kranz, Phillip D. Holler, Bryan K. Cho, Laurie A. Rund, Thomas C. Manning
Publikováno v:
International Journal of Cancer. 83:141-149
A variety of immunological approaches to cancer treatment are currently being explored. These include strategies designed to enhance or redirect the activity of T cells against tumors. Bispecific antibodies comprise a class of agents capable of redir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e086cb206bded04f793ef5b0f1e05dc1
https://doi.org/10.1002/(sici)1097-0215(19990924)83:1<141::aid-ijc24>3.0.co
https://doi.org/10.1002/(sici)1097-0215(19990924)83:1<141::aid-ijc24>3.0.co
Autor:
John J Seykora, Phillip D. Holler, Tzvete Dentchev, Erle S. Robertson, Kenneth O Simbiri, Misha Rosenbach, Karolyn A. Wanat
Background Viral-associated trichodysplasia of immunosuppression is a rare cutaneous eruption that is characterized by follicularly based shiny papules and alopecia with characteristic histopathologic findings of abnormally anagen follicules with exc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220136089edb21f663f19f53cafb7d49
https://europepmc.org/articles/PMC3346264/
https://europepmc.org/articles/PMC3346264/
Autor:
Jennifer D. Stone, Jianzhu Chen, David M. Kranz, Ailin Bai, Adam S. Chervin, Phillip D. Holler, Herman N. Eisen
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 183(2)
TCR interactions with cognate peptide-MHC (pepMHC) ligands are generally low affinity. This feature, together with the requirement for CD8/CD4 participation, has made it difficult to dissect relationships between TCR-binding parameters and T cell act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ae074dc3050ceb137750fc460070c4
https://pubmed.ncbi.nlm.nih.gov/19553539
https://pubmed.ncbi.nlm.nih.gov/19553539