Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Phillip D. Fromm"'
Autor:
Edward Abadir, Robin E. Gasiorowski, Kaitao Lai, Fiona Kupresanin, Adelina Romano, Pablo A. Silveira, Tsun‐Ho Lo, Phillip D. Fromm, Marina L. Kennerson, Harry J. Iland, P. Joy Ho, P. Mark Hogarth, Kenneth Bradstock, Derek N.J. Hart, Georgina J. Clark
Publikováno v:
Molecular Oncology, Vol 13, Iss 10, Pp 2107-2120 (2019)
Antibody‐based therapy in acute myeloid leukemia (AML) has been marred by significant hematologic toxicity due to targeting of both hematopoietic stem and progenitor cells (HSPCs). Achieving greater success with therapeutic antibodies requires care
Externí odkaz:
https://doaj.org/article/45bf9c7fc9c74c24a8afac22a249fba2
Autor:
Benjamin Y. Kong, Holly Bolton, Julius W. Kim, Pablo A. Silveira, Phillip D. Fromm, Georgina J. Clark
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Monoclonal antibodies targeting co-inhibitory immune checkpoint molecules have been successful in clinical trials of both solid and hematological malignancies as acknowledged by the 2018 Nobel Prize in Medicine, however improving clinical response ra
Externí odkaz:
https://doaj.org/article/b82281137cf74eb49b8db3637775a506
Autor:
Ziduo Li, Xinsheng Ju, Kenneth Lee, Candice Clarke, Jennifer L. Hsu, Edward Abadir, Christian E. Bryant, Suzanne Pears, Neroli Sunderland, Scott Heffernan, Annemarie Hennessy, Tsun-Ho Lo, Geoffrey A. Pietersz, Fiona Kupresanin, Phillip D. Fromm, Pablo A. Silveira, Con Tsonis, Wendy A. Cooper, Ilona Cunningham, Christina Brown, Georgina J. Clark, Derek N.J. Hart
Publikováno v:
Haematologica, Vol 103, Iss 4 (2018)
Chemotherapy and hematopoietic stem cell transplantation are effective treatments for most Hodgkin lymphoma patients, however there remains a need for better tumor-specific target therapy in Hodgkin lymphoma patients with refractory or relapsed disea
Externí odkaz:
https://doaj.org/article/63f149b189ae42c788167b1de64141fd
Autor:
Jennifer L. Hsu, Christian E. Bryant, Michael S. Papadimitrious, Benjamin Kong, Robin E. Gasiorowski, Daniel Orellana, Helen M. McGuire, Barbara Fazekas de St Groth, Douglas E. Joshua, P. Joy Ho, Stephen Larsen, Harry J. Iland, John Gibson, Georgina J. Clark, Phillip D. Fromm, Derek NJ Hart
Publikováno v:
OncoImmunology, Vol 7, Iss 4 (2018)
Only modest advances in AML therapy have occurred in the past decade and relapse due to residual disease remains the major challenge. The potential of the immune system to address this is evident in the success of allogeneic transplantation, however
Externí odkaz:
https://doaj.org/article/acfda01cb5dd4a4c8588ced75cab6370
Autor:
Sébastien Anguille, Eva Lion, Jurjen Tel, I. Jolanda M de Vries, Karen Couderé, Phillip D. Fromm, Viggo F. Van Tendeloo, Evelien L. Smits, Zwi N. Berneman
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/b710920a9f5d4d29b88c562cf4a03127
Autor:
Robert Markham, Phillip D. Fromm, Alison J. Hey-Cunningham, Helen M. McGuire, A. Riaz, F. Kupresanin
Publikováno v:
Reproductive Sciences. 29:229-242
Evidence to date supports regulatory T cell (Treg) alterations in endometriosis; however, the relationship remains unclear, and Tregs have not previously been investigated with respect to infertility in endometriosis. This prospective cross-sectional
Autor:
Michael S. Papadimitrious, Christian E Bryant, Derek N.J. Hart, Tsun-Ho Lo, Pablo A. Silveira, Ahmed H. Mekkawy, Xinsheng Ju, Barbara Fazekas de St Groth, Phillip D. Fromm, John Gibson, Elizabeth Newman, Helen M. McGuire, Jennifer Hsu, Adelina Romano, Georgina J. Clark, Fiona Kupresanin, Ilona Cunningham, Benjamin Y. Kong, Wei-Hsun Hsu, P. Mark Hogarth, Edward Abadir
Publikováno v:
Journal of Leukocyte Biology. 107:323-339
Myeloid lineage cells present in human peripheral blood include dendritic cells (DC) and monocytes. The DC are identified phenotypically as HLA-DR+ cells that lack major cell surface lineage markers for T cells (CD3), B cells (CD19, CD20), NK cells (
Autor:
P. Joy Ho, Kenneth F. Bradstock, Tsun-Ho Lo, Phillip D. Fromm, Harry J. Iland, Derek N.J. Hart, Adelina Romano, Fiona Kupresanin, Marina L. Kennerson, Kaitao Lai, Robin Gasiorowski, Georgina J. Clark, Edward Abadir, Pablo A. Silveira, P. Mark Hogarth
Publikováno v:
Molecular Oncology
Molecular Oncology, Vol 13, Iss 10, Pp 2107-2120 (2019)
Molecular Oncology, Vol 13, Iss 10, Pp 2107-2120 (2019)
Antibody‐based therapy in acute myeloid leukemia (AML) has been marred by significant hematologic toxicity due to targeting of both hematopoietic stem and progenitor cells (HSPCs). Achieving greater success with therapeutic antibodies requires care
Autor:
Derek N.J. Hart, Michael S. Papadimitrious, Christian E Bryant, Benjamin Y. Kong, S. Sutherland, Phillip D. Fromm
Publikováno v:
Seminars in Cell & Developmental Biology. 86:77-88
The ability of immune therapies to control cancer has recently generated intense interest. This therapeutic outcome is reliant on T cell recognition of tumour cells. The natural function of dendritic cells (DC) is to generate adaptive responses, by p
Autor:
Derek N.J. Hart, Wei-Hsun Hsu, Fiona Kupresanin, Renz Alingcastre, Xinsheng Ju, Georgina J. Clark, Candice Clarke, Zehra Elgundi, Christian E Bryant, Kenneth F. Bradstock, Helen M. McGuire, Kenneth Lee, Ziduo Li, Phillip D. Fromm, Barbara Fazekas de St Groth, Tsun-Ho Lo, Stephen Larsen, John Gibson, Nirupama D. Verma, Pablo A. Silveira, Jennifer Hsu
Publikováno v:
The Journal of Immunology. 197:4613-4625
CD83 is a member of the Ig gene superfamily, first identified in activated lymphocytes. Since then, CD83 has become an important marker for defining activated human dendritic cells (DC). Several potential CD83 mRNA isoforms have been described, inclu