Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Phillip D. Dunne"'
Autor:
Kevin Lynch, Sean O. Hynes, Michael O'Dwyer, Laurence J. Egan, Emma M. Kerr, Aideen E. Ryan, Kelly M. Redmond, K. DeVeirman, M. Craughwell, A. Canney, Hannah Egan, Phillip D. Dunne, Karin Vanderkerken, Oliver Treacy, Margaret Sheehan, Grace O’Malley, Aisling Hogan, Thomas Ritter, Niamh A Leonard
Immunosuppressive tumour microenvironments (TME) reduce the effectiveness of immune responses in cancer. Non-haematopoietic mesenchymal stromal cells (MSC), the precursor to cancer associated fibroblasts (CAFs), dictate tumour progression by enhancin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20db148b431cd3997a937e80a670dc25
https://doi.org/10.1101/2021.06.18.447879
https://doi.org/10.1101/2021.06.18.447879
Autor:
Alpesh Shah, Vanessa Martins, Simon S. McDade, Emma M. Kerr, Tomoko Smyth, Phillip D. Dunne, Vicky M. Coyle, Mark Lawler, Daniel B. Longley, Katie Stott, C. Latimer, William J. McDaid, Joanne M. Munck, Jennifer Fox, Christopher McCann, Tamas Sessler, Nyree Crawford
Cancer cells frequently express elevated levels of Inhibitor of Apoptosis Proteins (IAPs): cIAPI, cIAP2 and XIAP. Elevated expression of cIAP1 and cIAP2 (but not XIAP) significantly correlated with poor prognosis in microsatellite stable (MSS) stage-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9537a0da3b40185609068afe7dd72306
https://doi.org/10.1101/2020.11.20.391680
https://doi.org/10.1101/2020.11.20.391680
Autor:
Vicky M. Coyle, Simon S. McDade, Laurence J. Egan, Aideen E. Ryan, Katherine McAllister, Phillip D. Dunne, Andrea Lees, Peter Gallagher, Christopher McCann, Gemma M.A. Gregg, Tamas Sessler, Daniel B. Longley, Jamie Z. Roberts, Wendy L. Allen, Nyree Crawford, Emma M. Kerr, Mark Wappett, Patrick G. Johnston, Kirsty M. McLaughlin, Melissa Labonte-Wilson, Alexander J. McIntyre, Caitriona Holohan, Fiammetta Falcone, Gerard P. Quinn
How p53 differentially activates cell cycle arrest versus cell death remains poorly understood. Here, we demonstrate that upregulation of canonical pro-apoptotic p53 target genes in colon cancer cells imposes a critical dependence on the long splice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0611e428fef38e39ea43e58a06022cb5
Autor:
P.G. Johnston, Vicky M. Coye, Emma M. Kerr, Peter Gallagher, Phillip D. Dunne, Fiammetta Falcone, Caitriona Holohan, Simon S. McDade, Alexander J. McIntyre, Andrea Lees, Laurence J. Egan, Gemma M.A. Gregg, Aideen E. Ryan, Nyree Crawford, Wendy L. Allen, Chris McCann, Thomas Sessler, Katherine McAllister, Daniel B. Longley, Jamie Z. Roberts, Melissa Labonte-Wilson, Gerard P. Quinn, Mark Wappett, Kirsty M. McLaughlin
Publikováno v:
Cancer Research. 80:2409-2409
Background: How p53 differentially activates cell cycle arrest versus cell death remains poorly understood. Understanding the mechanisms governing the switch from p53-induced cell-fates is important for optimising efficacy of p53-activating therapies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd351a041a5659d120e87acce5e6975c
https://doi.org/10.1158/1538-7445.am2020-2409
https://doi.org/10.1158/1538-7445.am2020-2409
Autor:
Fiammetta Falcone, Gemma M.A. Gregg, Simon S. McDade, Gerard P. Quinn, Longley B. Daniel, Alexander J. McIntyre, Andrea Lees, Phillip D. Dunne, Sessler Tamas, Nyree Crawford, Darragh G. McArt, Mark Lawler
Publikováno v:
Cancer Research. 78:4385-4385
Background The tumor suppressive functions of the p53 transcription factor are inactivated via mutations or suppressed through non-mutational mechanisms in almost all cancer cells. A better understanding of the mechanisms through which p53 differenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a749a6e315b5ed2d2913a53831c135c
https://doi.org/10.1158/1538-7445.am2018-4385
https://doi.org/10.1158/1538-7445.am2018-4385