Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Phillip D Zamore"'
Autor:
Yu Fu, Yujing Yang, Han Zhang, Gwen Farley, Junling Wang, Kaycee A Quarles, Zhiping Weng, Phillip D Zamore
Publikováno v:
eLife, Vol 7 (2018)
We report a draft assembly of the genome of Hi5 cells from the lepidopteran insect pest, Trichoplusia ni, assigning 90.6% of bases to one of 28 chromosomes and predicting 14,037 protein-coding genes. Chemoreception and detoxification gene families re
Externí odkaz:
https://doaj.org/article/ace83d72deb04817b8e59d1186487194
Publikováno v:
eLife, Vol 4 (2015)
Many RNAs, including pre-mRNAs and long non-coding RNAs, can be thousands of nucleotides long and undergo complex post-transcriptional processing. Multiple sites of alternative splicing within a single gene exponentially increase the number of possib
Externí odkaz:
https://doaj.org/article/5d826ee328fb40e89f4fc4c7cd27f361
Autor:
Gregory J Babcock, Sowmya Iyer, Heidi L Smith, Yang Wang, Kirk Rowley, Donna M Ambrosino, Phillip D Zamore, Brian G Pierce, Deborah C Molrine, Zhiping Weng
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100325 (2014)
Chronic hepatitis C virus (HCV) infection is the most common cause of end-stage liver disease, often leading to liver transplantation, in which case circulating virions typically infect the transplanted liver within hours and viral concentrations can
Externí odkaz:
https://doaj.org/article/443c65ec108248369f81119f193b6e34
Autor:
Dianne S Schwarz, Hongliu Ding, Lori Kennington, Jessica T Moore, Janell Schelter, Julja Burchard, Peter S Linsley, Neil Aronin, Zuoshang Xu, Phillip D Zamore
Publikováno v:
PLoS Genetics, Vol 2, Iss 9, p e140 (2006)
Small interfering RNAs (siRNAs), the guides that direct RNA interference (RNAi), provide a powerful tool to reduce the expression of a single gene in human cells. Ideally, dominant, gain-of-function human diseases could be treated using siRNAs that s
Externí odkaz:
https://doaj.org/article/eb326f6c2d474e3fb8c5df12834e5b11
Autor:
Klaus Förstemann, Yukihide Tomari, Tingting Du, Vasily V Vagin, Ahmet M Denli, Diana P Bratu, Carla Klattenhoff, William E Theurkauf, Phillip D Zamore
Publikováno v:
PLoS Biology, Vol 3, Iss 7, p e236 (2005)
microRNAs (miRNAs) are single-stranded, 21- to 23-nucleotide cellular RNAs that control the expression of cognate target genes. Primary miRNA (pri-miRNA) transcripts are transformed to mature miRNA by the successive actions of two RNase III endonucle
Externí odkaz:
https://doaj.org/article/f4a0cad3bdc04420b93e7f0e7932bd6e
Publikováno v:
PLoS Biology, Vol 2, Iss 4, p E98 (2004)
Hundreds of microRNAs (miRNAs) and endogenous small interfering RNAs (siRNAs) have been identified from both plants and animals, yet little is known about their biochemical modes of action or biological functions. Here we report that 2'-O-methyl olig
Externí odkaz:
https://doaj.org/article/4539f2509eda48698e0b4ccd1ad70acf
Autor:
Sukanya Iyer, Aamir Mir, Joel Vega-Badillo, Benjamin P. Roscoe, Raed Ibraheim, Lihua Julie Zhu, Jooyoung Lee, Pengpeng Liu, Kevin Luk, Esther Mintzer, Dongsheng Guo, Josias Soares de Brito, Charles P. Emerson, Phillip D. Zamore, Erik J. Sontheimer, Scot A. Wolfe
Publikováno v:
The CRISPR Journal. 5:685-701
While genome editing has been revolutionized by the advent of CRISPR-based nucleases, difficulties in achieving efficient, nuclease-mediated, homology-directed repair (HDR) still limit many applications. Commonly used DNA donors such as plasmids suff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2676939cee7f1aebba005624d2b76eb9
https://doi.org/10.1089/crispr.2022.0058
https://doi.org/10.1089/crispr.2022.0058
Autor:
Amena Arif, Shannon Bailey, Natsuko Izumi, Todd A. Anzelon, Deniz M. Ozata, Cecilia Andersson, Ildar Gainetdinov, Ian J. MacRae, Yukihide Tomari, Phillip D. Zamore
Publikováno v:
Nature. 608:618-625
Argonaute proteins use nucleic acid guides to find and bind specific DNA or RNA target sequences. Argonaute proteins have diverse biological functions and many retain their ancestral endoribonuclease activity, cleaving the phosphodiester bond between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703fb3283d992e25866ef0b761130585
https://doi.org/10.1038/s41586-022-05009-0
https://doi.org/10.1038/s41586-022-05009-0
Autor:
Zexiang Chen, Gitali Devi, Amena Arif, Phillip D. Zamore, Erik J. Sontheimer, Jonathan K. Watts
Publikováno v:
ACS chemical biology. 17(5)
CRISPR-Cas technology has revolutionized genome editing. Its broad and fast-growing application in biomedical research and therapeutics has led to increased demand for guide RNAs. The synthesis of chemically modified single-guide RNAs (sgRNAs) contai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886d7343a4e11f763d87bfedeac22c16
https://pubmed.ncbi.nlm.nih.gov/35446558
https://pubmed.ncbi.nlm.nih.gov/35446558
Autor:
Pei Hsuan Wu, Yu Fu, Phillip D. Zamore, Katharine Cecchini, Cansu Colpan, Amena Arif, Tianxiong Yu, Deniz M. Ozata, Zhiping Weng, Ildar Gainetdinov
Publikováno v:
Nature genetics, Vol. 52, No 7 (2020) pp. 728-739
Pachytene PIWI-interacting RNAs (piRNAs), which comprise >80% of small RNAs in the adult mouse testis, have been proposed to bind and regulate target RNAs like microRNAs, cleave targets like short interfering RNAs or lack biological function altogeth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e3488b621c481bfc2eae3efe9718cb
https://doi.org/10.1038/s41588-020-0657-7
https://doi.org/10.1038/s41588-020-0657-7