Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Phillip C Aoto"'
Autor:
Jui-Hung Weng, Phillip C Aoto, Robin Lorenz, Jian Wu, Sven H Schmidt, Jascha T Manschwetus, Pallavi Kaila-Sharma, Steve Silletti, Sebastian Mathea, Deep Chatterjee, Stefan Knapp, Friedrich W Herberg, Susan S Taylor
Publikováno v:
PLoS Biology, Vol 20, Iss 2, p e3001427 (2022)
The 2 major molecular switches in biology, kinases and GTPases, are both contained in the Parkinson disease-related leucine-rich repeat kinase 2 (LRRK2). Using hydrogen-deuterium exchange mass spectrometry (HDX-MS) and molecular dynamics (MD) simulat
Externí odkaz:
https://doaj.org/article/2cc122c6b3a04604858609a307766692
Autor:
Tsan-Wen Lu, Phillip C Aoto, Jui-Hung Weng, Cole Nielsen, Jennifer N Cash, James Hall, Ping Zhang, Sanford M Simon, Michael A Cianfrocco, Susan S Taylor
Publikováno v:
PLoS Biology, Vol 18, Iss 12, p e3001018 (2020)
When the J-domain of the heat shock protein DnaJB1 is fused to the catalytic (C) subunit of cAMP-dependent protein kinase (PKA), replacing exon 1, this fusion protein, J-C subunit (J-C), becomes the driver of fibrolamellar hepatocellular carcinoma (F
Externí odkaz:
https://doaj.org/article/764ecb3e6d3f4f3ea2fdf9f9c01927a8
Autor:
David Oyen, Jonathan L Torres, Phillip C Aoto, Yevel Flores-Garcia, Špela Binter, Tossapol Pholcharee, Sean Carroll, Sini Reponen, Rachael Wash, Qi Liang, Franck Lemiale, Emily Locke, Allan Bradley, C Richter King, Daniel Emerling, Paul Kellam, Fidel Zavala, Andrew B Ward, Ian A Wilson
Publikováno v:
PLoS Pathogens, Vol 16, Iss 3, p e1008373 (2020)
Lasting protection has long been a goal for malaria vaccines. The major surface antigen on Plasmodium falciparum sporozoites, the circumsporozoite protein (PfCSP), has been an attractive target for vaccine development and most protective antibodies s
Externí odkaz:
https://doaj.org/article/2b45fbb0cb2843a2913970e92e8e5bed
Autor:
David C. Wych, Phillip C. Aoto, Lily Vu, Alexander M. Wolff, David L. Mobley, James S. Fraser, Susan S. Taylor, Michael E. Wall
Publikováno v:
Acta crystallographica. Section D, Structural biology, vol 79, iss Pt 1
To assess the potential benefits of molecular-dynamics (MD) simulations for macromolecular crystallography (MX), we performed room-temperature X-ray diffraction studies of the catalytic subunit of mouse protein kinase A (PKA-C). We then performed cry
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 47
Topological analysis of amino acid networks is a common method that can help to understand the roles of individual residues. The most popular approach for network construction is to create a connection between residues if they interact. These interac
Autor:
Friedrich W. Herberg, Jascha Tobias Manschwetus, Pallavi Kaila-Sharma, Sebastian Mathea, Robin Lorenz, Sven H. Schmidt, Stefan Knapp, Phillip C. Aoto, Jui-Hung Weng, Jian Wu, Susan S. Taylor
The two major molecular switches in biology, kinases and GTPases, are both contained in the Parkinson’s Disease-related Leucine-rich repeat kinase 2 (LRRK2). Using hydrogen-deuterium exchange mass spectrometry (HDX-MS) and Molecular Dynamics (MD) s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91ac7fe36b63daffd10649a5c41fa61f
https://doi.org/10.1101/2021.09.29.462278
https://doi.org/10.1101/2021.09.29.462278
Autor:
Cole Nielsen, Ping Zhang, Sanford M. Simon, Phillip C. Aoto, Jui-Hung Weng, Susan S. Taylor, Tsan-Wen Lu, Jennifer N. Cash, Michael A. Cianfrocco, James A. Hall
Publikováno v:
PLoS Biology, Vol 18, Iss 12, p e3001018 (2020)
PLoS Biology
PLoS Biology
When the J-domain of the heat shock protein DnaJB1 is fused to the catalytic (C) subunit of cAMP-dependent protein kinase (PKA), replacing exon 1, this fusion protein, J-C subunit (J-C), becomes the driver of fibrolamellar hepatocellular carcinoma (F
Autor:
Steve Silletti, Stefan Knapp, Friedrich W. Herberg, Phillip C. Aoto, Junru Hu, Sven H. Schmidt, Elizabeth A. Komives, Sebastian Mathea, Susan S. Taylor, Maximilian Wallbott, Daniela Boassa, Jui-Hung Weng
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 23
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Significance To achieve a mechanistic understanding of LRRK2, a multidomain protein kinase, we must understand how the conformational landscape is changed by specific mutations that cause LRRK2 to become a driver of Parkinson’s disease (PD). To mee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01cc0525661681d71ed99cfc528ea344
https://doi.org/10.1101/2020.07.13.198069
https://doi.org/10.1101/2020.07.13.198069
Autor:
Špela Binter, Daniel Emerling, Yevel Flores-Garcia, Sini Reponen, Andrew B. Ward, C. Richter King, Rachael S. Wash, Sean M. Carroll, Paul Kellam, Phillip C. Aoto, Jonathan L. Torres, David Oyen, Fidel Zavala, Allan Bradley, Emily Locke, Franck Lemiale, Ian A. Wilson, Qi Liang, T. Pholcharee
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 3, p e1008373 (2020)
PLoS Pathogens, Vol 16, Iss 3, p e1008373 (2020)
Lasting protection has long been a goal for malaria vaccines. The major surface antigen on Plasmodium falciparum sporozoites, the circumsporozoite protein (PfCSP), has been an attractive target for vaccine development and most protective antibodies s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c6d0fca680bc5b7a215b61e2d3b555
http://hdl.handle.net/10044/1/81513
http://hdl.handle.net/10044/1/81513
Autor:
Isabella Torrente, Geert Mortier, Lily Vu, Alessandro De Luca, Mennat I Mehrez, Mahmoud Y. Issa, Britta Schlott Kristiansen, Phillip C. Aoto, Maria Kibaek, Michael S. Hildebrand, Pablo Lapunzina, Jair Tenorio, Francesca Piceci-Sparascio, Gaoyang Li, Ana Rivera-Barahona, Adrian Palencia-Campos, Daniela Bertinetti, Melanie Bahlo, Valérie Cormier-Daire, Silke Peeters, Patricia Soto‐Bielicka, Alban Ziegler, Samia A. Temtamy, Wim Van Hul, Mathew Wallis, Ingrid E. Scheffer, Ghada A. Otaify, Mona Aglan, Aia E. Jønch, Amy L Schneider, Mark F. Bennett, Bjørn Steen Skålhegg, Eveline Boudin, Samira Ismail, Friedrich W. Herberg, Susan S. Taylor, Blaine Baker, Victor L. Ruiz-Perez, Matthew Coleman, Céline Huber, Dominique Bonneau, Erik M F Machal
Publikováno v:
The American journal of human genetics
Palencia-Campos, A, Aoto, P C, Machal, E M F, Rivera-Barahona, A, Soto-Bielicka, P, Bertinetti, D, Baker, B, Vu, L, Piceci-Sparascio, F, Torrente, I, Boudin, E, Peeters, S, Van Hul, W, Huber, C, Bonneau, D, Hildebrand, M S, Coleman, M, Bahlo, M, Bennett, M F, Schneider, A L, Scheffer, I E, Kibæk, M, Kristiansen, B S, Issa, M Y, Mehrez, M I, Ismail, S, Tenorio, J, Li, G, Skålhegg, B S, Otaify, G A, Temtamy, S, Aglan, M, Jønch, A E, De Luca, A, Mortier, G, Cormier-Daire, V, Ziegler, A, Wallis, M, Lapunzina, P, Herberg, F W, Taylor, S S & Ruiz-Perez, V L 2020, ' Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome ', American Journal of Human Genetics, vol. 107, no. 5, pp. 977-988 . https://doi.org/10.1016/j.ajhg.2020.09.005
Am J Hum Genet
Digital.CSIC. Repositorio Institucional del CSIC
instname
Palencia-Campos, A, Aoto, P C, Machal, E M F, Rivera-Barahona, A, Soto-Bielicka, P, Bertinetti, D, Baker, B, Vu, L, Piceci-Sparascio, F, Torrente, I, Boudin, E, Peeters, S, Van Hul, W, Huber, C, Bonneau, D, Hildebrand, M S, Coleman, M, Bahlo, M, Bennett, M F, Schneider, A L, Scheffer, I E, Kibæk, M, Kristiansen, B S, Issa, M Y, Mehrez, M I, Ismail, S, Tenorio, J, Li, G, Skålhegg, B S, Otaify, G A, Temtamy, S, Aglan, M, Jønch, A E, De Luca, A, Mortier, G, Cormier-Daire, V, Ziegler, A, Wallis, M, Lapunzina, P, Herberg, F W, Taylor, S S & Ruiz-Perez, V L 2020, ' Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome ', American Journal of Human Genetics, vol. 107, no. 5, pp. 977-988 . https://doi.org/10.1016/j.ajhg.2020.09.005
Am J Hum Genet
Digital.CSIC. Repositorio Institucional del CSIC
instname
PRKACA and PRKACB code for two catalytic subunits (Cα and Cβ) of cAMP-dependent protein kinase (PKA), a pleiotropic holoenzyme that regulates numerous fundamental biological processes such as metabolism, development, memory, and immune response. We