Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Phillip A. Yates"'
Autor:
Michael B. Heskett, Athanasios E. Vouzas, Leslie G. Smith, Phillip A. Yates, Christopher Boniface, Eric E. Bouhassira, Paul T. Spellman, David M. Gilbert, Mathew J. Thayer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Heskett et al. describe several members of a class of long non-coding RNAs, known as ASARs, which show distinct epigenetic regulation between subclonal lineages and are essential for normal DNA replication timing and stability of human autosomes.
Externí odkaz:
https://doaj.org/article/4e4cb57c90794f0db665eeb98bc386ca
Publikováno v:
eLife, Vol 13 (2024)
ASARs are a family of very-long noncoding RNAs that control replication timing on individual human autosomes, and are essential for chromosome stability. The eight known ASAR lncRNAs remain closely associated with their parent chromosomes. Analysis o
Externí odkaz:
https://doaj.org/article/71f75e07da1241659329a0b0acb51d1a
Autor:
Phillip J Yates, Jennifer Moore, Jennifer Han, Andrew Skingsley, Gretja Schnell, Andrea L Cathcart, Melissa Aldinger, Amanda Peppercorn, Jill Walker
Publikováno v:
Open Forum Infectious Diseases. 9
Background Sotrovimab is a human monoclonal antibody targeting a conserved region of the SARS-CoV-2 spike (S) protein. COMET-PEAK was a 3-part, phase 2 study that evaluated intravenous (500 mg) and intramuscular (500 mg and 250 mg) administration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::768a5daa8138e442cf09811d32e8ff7b
https://doi.org/10.1093/ofid/ofac492.382
https://doi.org/10.1093/ofid/ofac492.382
Autor:
Yvonne Tami, Shihyun You, Melanie Paff, Jeong-Won Jang, Robert Elston, Sung-Jae Park, Phillip J. Yates, Yu Tao, Jung Hwan Yoon, C. Frank Bennett, Jennifer Cremer, Jeong Heo, Dickens Theodore, T. Jesse Kwoh, Man-Fung Yuen, Young-Oh Kweon, Fiona Campbell
Publikováno v:
Nature Medicine
Cell Reports Medicine
Cell Reports Medicine
Chronic infection with hepatitis B virus (HBV) leads to an increased risk of death from cirrhosis and hepatocellular carcinoma. Functional cure rates are low with current treatment options (nucleos(t)ide analogs (NAs) and pegylated interferons). Bepi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee63e356dfb8c2df2abc6ba2ec04af2
http://europepmc.org/articles/PMC8516644
http://europepmc.org/articles/PMC8516644
ASARs are a family of very-long noncoding RNAs that control replication timing on individual human autosomes, and are essential for chromosome stability. The eight known ASAR genes express RNAs that remain closely associated with their parent chromos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f407cab2b63ab7f2f19b22d80036fa7
https://doi.org/10.1101/2022.06.04.494840
https://doi.org/10.1101/2022.06.04.494840
Autor:
Michael B. Heskett, Athanasios E. Vouzas, Leslie G. Smith, Phillip A. Yates, Christopher Boniface, Eric E. Bouhassira, Paul Spellman, David M. Gilbert, Mathew J. Thayer
ASARs are long noncoding RNA genes that control replication timing of entire human chromosomes in cis. The three known ASAR genes are located on human chromosomes 6 and 15, and are essential for chromosome integrity. To identify ASARs on all human ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b9313c521b150845bc3aa8664ba9c39
https://doi.org/10.1101/2022.04.25.489405
https://doi.org/10.1101/2022.04.25.489405
Publikováno v:
Mol Microbiol
Parasites are by definition organisms that utilize resources from a host to support their existence, thus, promoting their ability to establish long-term infections and disease. Hence, sensing and acquiring nutrients for which the parasite and host c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059c00af0522ac4e91a5a3fa06da84ea
https://doi.org/10.1111/mmi.14635
https://doi.org/10.1111/mmi.14635
Autor:
Heidi J. Einolf, Barry Jones, Phillip D. Yates, Theunis C. Goosen, Diane Ramsden, Conrad Fung, Y. Amy Siu, Niresh Hariparsad, Simon Wong, Liangfu Chen, Jairam Palamanda, George Zhang, Donald J. Tweedie, Shannon Dallas
Publikováno v:
Drug Metabolism and Disposition. 49:94-110
Translational and ADME Sciences Leadership Group Induction Working Group (IWG) presents an analysis on the time course for cytochrome P450 induction in primary human hepatocytes. Induction of CYP1A2, CYP2B6, and CYP3A4 was evaluated by seven IWG labo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa020936133a247e86ba65e02dc01b76
https://doi.org/10.1124/dmd.120.000055
https://doi.org/10.1124/dmd.120.000055
Autor:
Phillip J. Yates, Malek Okour, Jon Collins, Grace Roberts, Peiying Zuo, Helen A. Watson, Denise Shortino, Aline Barth, Mohammad Hossain, Amanda Peppercorn
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 1, Pp 157-168 (2020)
Clinical and Translational Science
Clinical and Translational Science
Zanamivir is a potent and highly selective inhibitor of influenza neuraminidase in which the inhibition of this enzyme prevents the virus from infecting other cells and specifically prevents release of the new virion from the host cell membrane. It i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa5563b82f9d824958d5a466ac2e44a
https://doaj.org/article/26aa4ebc79db4540828e09fb7ca0c5b5
https://doaj.org/article/26aa4ebc79db4540828e09fb7ca0c5b5
Publikováno v:
Virus Research. 325:199039
Influenza infection causes substantial morbidity and mortality during seasonal epidemics and pandemics. Antivirals, including neuraminidase inhibitors, play an important role in the treatment of severely ill patients infected with influenza. Resistan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9972847d7e464eb0f2a55cdafa5205cb
https://doi.org/10.1016/j.virusres.2023.199039
https://doi.org/10.1016/j.virusres.2023.199039