Zobrazeno 1 - 10
of 569
pro vyhledávání: '"Phillip A. Sharp"'
Autor:
Kavi Gupta, Chenxi Yang, Kayla McCue, Osbert Bastani, Phillip A. Sharp, Christopher B. Burge, Armando Solar-Lezama
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-23 (2024)
Abstract Sequence-specific RNA-binding proteins (RBPs) play central roles in splicing decisions. Here, we describe a modular splicing architecture that leverages in vitro-derived RNA affinity models for 79 human RBPs and the annotated human genome to
Externí odkaz:
https://doaj.org/article/b179444b841b409b98a2435b9e20ab80
Autor:
Sara J.C. Gosline, Allan M. Gurtan, Courtney K. JnBaptiste, Andrew Bosson, Pamela Milani, Simona Dalin, Bryan J. Matthews, Yoon S. Yap, Phillip A. Sharp, Ernest Fraenkel
Publikováno v:
Cell Reports, Vol 14, Iss 2, Pp 310-319 (2016)
MicroRNAs (miRNAs) regulate diverse biological processes by repressing mRNAs, but their modest effects on direct targets, together with their participation in larger regulatory networks, make it challenging to delineate miRNA-mediated effects. Here,
Externí odkaz:
https://doaj.org/article/b2e0314101f1488489b7d786514c354a
Autor:
Stefani Spranger, Rakesh K Jain, Kim Nguyen, Arjun Bhutkar, Ivy Chen, Dig Bijay Mahat, Heena Kumra, Emily Metcalf, Sarah Castro, William W Ho, Brandon Sullivan, Leon K Yim, Vikash Chauhan, Hernandez Moura Silva, Phillip A Sharp
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)
Externí odkaz:
https://doaj.org/article/794447e319c14e92a0c1865d72dd16fb
Autor:
Shahid Rehan, Dale Tranter, Phillip P. Sharp, Eric Lowe, Janet L. Anderl, Tony Muchamuel, Vahid Abrishami, Suvi Kuivanen, Nicole Wenzell, Andy Jennings, Chakrapani Kalyanaraman, Gregory B. Craven, Tomas Strandin, Matti Javanainen, Olli Vapalahti, Matt Jacobson, Dustin McMinn, Christopher J. Kirk, Juha T. Huiskonen, Jack Taunton, Ville O. Paavilainen
Publikováno v:
Nature Chemical Biology.
Preventing the biogenesis of disease-relevant proteins is an attractive therapeutic strategy, but attempts to target essential protein biogenesis factors have been hampered by excessive toxicity. Here we describe KZR-8445, a cyclic depsipeptide that
Autor:
Megan L. Insco, Brian J. Abraham, Sara J. Dubbury, Ines H. Kaltheuner, Sofia Dust, Constance Wu, Kevin Y. Chen, David Liu, Stanislav Bellaousov, Anna M. Cox, Benjamin J. E. Martin, Tongwu Zhang, Calvin G. Ludwig, Tania Fabo, Rodsy Modhurima, Dakarai E. Esgdaille, Telmo Henriques, Kevin M. Brown, Stephen J. Chanock, Matthias Geyer, Karen Adelman, Phillip A. Sharp, Richard A. Young, Paul L. Boutz, Leonard I. Zon
Publikováno v:
Science
RNA surveillance pathways detect and degrade defective transcripts to ensure RNA fidelity. We found that disrupted nuclear RNA surveillance is oncogenic. Cyclin-dependent kinase 13 ( CDK13 ) is mutated in melanoma, and patient-mutated CDK13 accelerat
Supplementary Table 4 from The Octamer Binding Transcription Factor Oct-1 Is a Stress Sensor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d34178462d4440ea019c36a7094d0893
https://doi.org/10.1158/0008-5472.22364757.v1
https://doi.org/10.1158/0008-5472.22364757.v1
The POU-domain transcription factor Oct-1 is widely expressed in adult tissues and has been proposed to regulate a large group of target genes. Microarray expression profiling was used to evaluate gene expression changes in Oct-1-deficient mouse fibr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a5c7f9b6d7b218d9ce8661224bbe41d
https://doi.org/10.1158/0008-5472.c.6494343.v1
https://doi.org/10.1158/0008-5472.c.6494343.v1
Supplementary Table 5 from The Octamer Binding Transcription Factor Oct-1 Is a Stress Sensor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a571612f9ec1870c35982c37709928a
https://doi.org/10.1158/0008-5472.22364754
https://doi.org/10.1158/0008-5472.22364754
Supplementary Table 2 from The Octamer Binding Transcription Factor Oct-1 Is a Stress Sensor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2111c42b338d20cd2ea200a2578db130
https://doi.org/10.1158/0008-5472.22364763.v1
https://doi.org/10.1158/0008-5472.22364763.v1
Supplementary Table 1 from The Octamer Binding Transcription Factor Oct-1 Is a Stress Sensor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1a1b7b398debc365ad15c3eda9f1a6
https://doi.org/10.1158/0008-5472.22364766
https://doi.org/10.1158/0008-5472.22364766