Oligomerization engineering of the fluorinase enzyme leads to an active trimer that supports synthesis of fluorometabolites in vitro

Autor: Tiia Kittilä, Patricia Calero, Folmer Fredslund, Phillip T. Lowe, David Tezé, Manuel Nieto‐Domínguez, David O’Hagan, Pablo I. Nikel, Ditte H. Welner

Publikováno v: Microbial Biotechnology, Vol 15, Iss 5, Pp 1622-1632 (2022)

Summary The fluorinase enzyme represents the only biological mechanism capable of forming stable C–F bonds characterized in nature thus far, offering a biotechnological route to the biosynthesis of value‐added organofluorines. The fluorinase is k

Externí odkaz: https://doaj.org/article/30a605b318914efbbf5a7a77aa635e6c

4′-Fluoro-nucleosides and nucleotides: from nucleocidin to an emerging class of therapeutics

Autor: Phillip T. Lowe, David O’Hagan

Publikováno v: Chemical Society Reviews. 52:248-276

The history and development of 4'-fluoro-nucleosides is discussed in this review. This is a class of nucleosides which have their origin in the discovery of the rare fluorine containing natural product nucleocidin. Nucleocidin contains a fluorine ato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::168497d7eb2f214e844eb6796aa5a8da
https://doi.org/10.1039/d2cs00762b

Cyperus excurrens (Cyperaceae), a New Species from Karst Ponds in Southern Georgia, U.S.A

Autor: Phillip D. Lowe, J. Richard Carter

Publikováno v: Castanea. 87

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a00b52e4612b5b1c122b4b35fd10336
https://doi.org/10.2179/0008-7475.87.2.224

A fluoride-responsive genetic circuit enables in vivo biofluorination in engineered Pseudomonas putida

Autor: David O'Hagan, Daniel C. Volke, Charlotte Held Gotfredsen, Patricia Calero, Phillip T. Lowe, Pablo I. Nikel

Publikováno v: Calero, P, Volke, D C, Lowe, P T, Gotfredsen, C H, O'Hagan, D & Nikel, P I 2020, ' A fluoride-responsive genetic circuit enables in vivo biofluorination in engineered Pseudomonas putida ', Nature Communications, vol. 11, no. 1, 5045 . https://doi.org/10.1038/s41467-020-18813-x
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications

Fluorine is a key element in the synthesis of molecules broadly used in medicine, agriculture and materials. Addition of fluorine to organic structures represents a unique strategy for tuning molecular properties, yet this atom is rarely found in Nat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9084fd896bf19a5ad3b064386cf5252e
https://doi.org/10.1038/s41467-020-18813-x

Additions to the Flora of Georgia Vouchered at the University of Georgia (GA) and Valdosta State University (VSC) Herbaria

Autor: Thomas S. Patrick, J. Richard Carter, Wendy B. Zomlefer, Patrick S. Lynch, David E. Giannasi, Jennifer T. Miller, Eric P. Prostko, Steven C. Hughes, Sabrina Y.S. Sewell, James R. Allison, W. Wilson Baker, Alan S. Weakley, Phillip D. Lowe, Ron W. Lance

Publikováno v: Castanea. 83:124-139

Twenty-seven species, new to the flora of Georgia, are reported here and validated by cited voucher specimens at the University of Georgia (GA) and Valdosta State University (VSC) herbaria, the two largest herbaria in the state. Reassessment and comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f0fff09125e9cd86f4d16a516308821
https://doi.org/10.2179/17-151