Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Phillip A. Inglesby"'
Autor:
Jean-Marc Henry, David Milne, Dave Perkins, William Hicks, David R. J. Hose, Andrew D. Campbell, Alexander K. Mullen, Phillip A. Inglesby, Steven A. Raw, Martin F. Jones
Publikováno v:
Organic Process Research & Development. 27:488-495
Autor:
Lucie Miller-Potucka, Gall Malcolm Allan Young, Ian W. Ashworth, Andrew J. Robbins, Oliver T. Ring, Martin F. Jones, Barry R. Hayter, Rosemary A. Wordsworth, Adam J. Leahy, Lyn Powell, Phillip A. Inglesby, Alex L. Lamacraft, Okky Dwichandra Putra, Janette H. Cherryman, Thomas O. Ronson, Peter R. Hamilton, Simone Tomasi, Lauren R. Agnew, David C. McKinney
Publikováno v:
Organic Process Research & Development. 26:936-948
Autor:
Dobson Benjamin Charles, Chris Wimsey, Lai C. Chan, Steven A. Raw, Anna Jawor-Baczynska, David R. J. Hose, Martin F. Jones, David Perkins, Alex L. Lamacraft, Angus E. McMillan, Matthew Burns, Alan Steven, Alexander K. Mullen, Phillip A. Inglesby, Ahmed Elmekawy, Michael John Pilling
Publikováno v:
Organic Process Research & Development. 25:858-870
Route design and process development of the small nitrogen heterocycle 2·HCl, a constituent of AZD5718 (1), is described. The novel synthetic sequence to 2.HCl involves a desymmetrizing alkylation ...
Publikováno v:
Organic Process Research & Development. 24:1683-1689
Herein, we disclose the unique physical properties of diethanolamine (DEA) boronic esters that have facilitated the development of a simple and standard process for their synthesis and isolation us...
Autor:
Sahar McKeever-Abbas, Robert L. Woodward, David Whittaker, Janette H. Cherryman, Alex Crampton, Edward G. B. Eden-Rump, Martin F. Jones, Matthew Charles Evans, Ian W. Ashworth, Rebecca E. Meadows, Phillip A. Inglesby, Andrew D. Campbell, Kathryn Skilling, Jemma Clark
Publikováno v:
Organic Process Research & Development. 22:1801-1808
We developed a scalable Suzuki process for the synthesis of lanabecestat (+)-camsylate, an active pharmaceutical ingredient that was recently investigated in a Phase III clinical program for the treatment of early Alzheimer’s disease. The evolution
Publikováno v:
Angewandte Chemie
Angewandte Chemie (International Ed. in English)
Angewandte Chemie (International Edition)
Angewandte Chemie (International Ed. in English)
Angewandte Chemie (International Edition)
The functionalization of aryl and heteroaryls using α‐carbonyl sulfoxonium ylides without the help of a directing group has remained so far a neglected area, despite the advantageous safety profile of sulfoxonium ylides. Described herein are the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5a1ceea7108c950ef15732cfe01b90
http://livrepository.liverpool.ac.uk/3062445/1/ACIE2019.pdf
http://livrepository.liverpool.ac.uk/3062445/1/ACIE2019.pdf
Publikováno v:
Organic Process Research & Development. 22:633-640
An improved synthetic procedure for the multistep synthesis of aminoimidazole 6, a key intermediate in the preparation of lanabecestat (AZD3293/LY3314814), is described. Under intensified conditions (high temperature and elevated pressure), the overa
Publikováno v:
Angewandte Chemie International Edition. 57:673-677
Reported is the first example of a rhodium-mediated β-sulfide elimination, which represents a new mode of reactivity for late-transition-metal chemistry. This serendipitous discovery facilitates an ene-cycloisomerization of allylic-sulfide-containin
Publikováno v:
Organic Process Research & Development. 21:1404-1412
A new route to 2-oxopropanethioamide, a key intermediate in the synthesis of lanabecestat (AZD3293/LY3314814), is described by employing commercially available 2,2-diethoxypropionitrile as a raw material. In contrast to the previous route, this work
Publikováno v:
Organic Process Research & Development. 21:878-884
The development of a continuous-flow Sonogashira cross-coupling protocol using propyne gas for the synthesis of a key intermediate in the manufacturing of a β-amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, currently undergoing late s