Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Phillip A Saccone"'
1
Psychiatric Comorbidity and Multimorbidity in the EAGLES Trial: Descriptive Correlates and Associations With Neuropsychiatric Adverse Events, Treatment Adherence, and Smoking Cessation
Autor: David Lawrence, Phillip A Saccone, Neal Doran, Natassia V. Gaznick, John B. Correa, Benjamin S. McKenna, Sarah Dubrava, Robert M. Anthenelli
Publikováno v: Nicotine Tob Res
Introduction Psychiatric and substance use disorders represent barriers to smoking cessation. We sought to identify correlates of psychiatric comorbidity (CM; 2 diagnoses) and multimorbidity (MM; 3+ diagnoses) among smokers attempting to quit and to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01a1f5b6b0939d11ab12b9eb03e8a14
https://doi.org/10.1093/ntr/ntab056
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2
Characterization of the Discriminative Stimulus Effects of a NOP Receptor Agonist Ro 64-6198 in Rhesus Monkeys
Autor: Agnieszka Sulima, Kenner C. Rice, Angela M. Lindsey, Phillip A. Saccone, James H. Woods, Kathy A. Zelenock, Eric P. Prinssen, Jürgen Wichmann
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 357:17-23
Nociceptin/orphanin FQ receptor (NOP) agonists have been reported to produce antinociceptive effects in rhesus monkeys with comparable efficacy to μ-opioid receptor (MOP) agonists, but without their limiting side effects. There are also known to be
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ccf78ca4a8429c4afae2349f58f69f
https://doi.org/10.1124/jpet.115.231134
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3
The effects of ibudilast, a glial activation inhibitor, on opioid withdrawal symptoms in opioid-dependent volunteers
Autor: Suzanne K. Vosburg, Kirk W. Johnson, Ziva D. Cooper, Sandra D. Comer, Jermaine D. Jones, Martina Pavlicova, Phillip A. Saccone, Diana Martinez, Maria A. Sullivan, Jeanne M. Manubay, Andrew Glass
Publikováno v: Addiction Biology. 21:895-903
Glial activation is hypothesized to contribute directly to opioid withdrawal. This study investigated the dose-dependent effects of a glial cell modulator, ibudilast, on withdrawal symptoms in opioid-dependent volunteers after abrupt discontinuation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::248d7a94cd73f6d1f01d81c72c666306
https://doi.org/10.1111/adb.12261
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4
Comparison of a drug versus money and drug versus drug self-administration choice procedure with oxycodone and morphine in opioid addicts
Autor: Sandra D. Comer, William J. Kowalczyk, Maria A. Sullivan, Ziva D. Cooper, Jermaine D. Jones, Mary E. Smith, Suzanne K. Vosburg, Phillip A. Saccone, Verena E. Metz, Jeanne M. Manubay, Deena Peyser
Publikováno v: Behavioural Pharmacology. 24:504-516
This double-blind, placebo-controlled study investigated the effects of oral morphine (0, 45, 135 mg/70 kg) and oral oxycodone (0, 15, 45 mg/70 kg) on buprenorphine-maintained opioid addicts. As a 3: 1 morphine : oxycodone oral dose ratio yielded equ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2179976f2a9487072d8b7e41b7ba4de3
https://doi.org/10.1097/fbp.0b013e328363d1c4
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5
Effects of Acute Oral Naltrexone on the Subjective and Physiological Effects of Oral D-Amphetamine and Smoked Cocaine in Cocaine Abusers
Autor: Ziva D. Cooper, Suzanne K. Vosburg, Richard W. Foltin, Margaret Haney, Jermaine D. Jones, Paula Askalsky, Eric J. Rubin, Diana Martinez, Sandra D. Comer, Abigail Pines, Perrine Roux, Emily L Berkower, Phillip A. Saccone, Ellen A. Walker, Shanthi Mogali, Jeanne M. Manubay, Maria A. Sullivan
Publikováno v: Neuropsychopharmacology. 38:2427-2438
Despite the prevalent worldwide abuse of stimulants, such as amphetamines and cocaine, no medications are currently approved for treating this serious public health problem. Both preclinical and clinical studies suggest that the opioid antagonist nal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2afa7cea044d2e255e0f1a642c388dc
https://doi.org/10.1038/npp.2013.143
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6
Intranasal Opioid Administration in Rhesus Monkeys: PET Imaging and Antinociception
Autor: Xia Shao, Robert A. Koeppe, Kathy A. Zelenock, Peter J. H. Scott, James H. Woods, Angela M. Lindsey, Carole Quesada, Phillip S. Sherman, Phillip A. Saccone
The goal of this study was to evaluate the effects of intranasally administered opioids in rhesus monkeys using the tail-withdrawal assay, and to correlate these effects with measures of receptor occupancy using positron emission tomography (PET) ima
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49a59b4192e5dfdc549bb35f59061f98
https://europepmc.org/articles/PMC5074481/
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7
Impact of in-patient research participation on subsequent heroin use patterns: implications for ethics and public health
Autor: Jeanne M. Manubay, Suzanne K. Vosburg, Sandra D. Comer, Claudia Tindall, Ziva D. Cooper, Jermaine D. Jones, Maria A. Sullivan, Perrine Roux, Richard W. Foltin, Phillip A. Saccone, Janet Murray, Lionel Fugon
Publikováno v: Addiction. 107:642-649
Aims Research on drug dependence often involves the administration of drugs of abuse to experienced drug users under controlled laboratory conditions. The primary objective of this study was to assess whether participation in such research alters the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b5e0d497fc26ffc44b677f82e3a23b0
https://doi.org/10.1111/j.1360-0443.2011.03664.x
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8
Deficits in Dopamine D2 Receptors and Presynaptic Dopamine in Heroin Dependence: Commonalities and Differences with Other Types of Addiction
Autor: Phillip A. Saccone, Sandra D. Comer, Ronald L. Van Heertum, Diana Martinez, Daria Orlowska, Mark Slifstein, Stephanie H. Cook, Allegra Broft, Alex Grassetti, Fei Liu
Publikováno v: Biological Psychiatry. 71:192-198
Background Positron emission tomography (PET) imaging studies have shown that addiction to a number of substances of abuse is associated with a decrease in dopamine D 2/3 receptor binding and decreased presynaptic dopamine release in the striatum. So
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724e74fce76acf5825811f92a795e6e3
https://doi.org/10.1016/j.biopsych.2011.08.024
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9
Abuse liability of intravenous buprenorphine/naloxone and buprenorphine alone in buprenorphine-maintained intravenous heroin abusers
Autor: Herbert D. Kleber, Suzanne K. Vosburg, Jeanne M. Manubay, Sandra D. Comer, Maria A. Sullivan, Phillip A. Saccone, Leslie Amass, Ziva D. Cooper
Publikováno v: Addiction. 105:709-718
BACKGROUND Sublingual buprenorphine is an effective maintenance treatment for opioid dependence, yet intravenous buprenorphine misuse occurs. A buprenorphine/naloxone formulation was developed to mitigate this misuse risk. This randomized, double-bli
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::10f9630d63f25b198e233bff6c3f4caa
https://doi.org/10.1111/j.1360-0443.2009.02843.x
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10
Intrathecal nociceptin displaces a PET ligand for its receptor in the brain at analgesic doses in rhesus monkeys (658.1)
Autor: Xia Shao, Gail Winger, James H. Woods, Peter Scott, Phillip S. Sherman, Phillip A. Saccone, Carole Quesada, Michael R. Kilbourn
Publikováno v: The FASEB Journal. 28
The nociceptin receptor (NOP) has been investigated as a potential therapeutic target for pain control. Nociceptin, the endogenous ligand for NOP, produces analgesia in rodents and primates when gi...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a576a70237e8721d534b8bbea9a7eea3
https://doi.org/10.1096/fasebj.28.1_supplement.658.1
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