Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Phillip A Newmark"'
Autor:
Melanie Issigonis, Akshada B Redkar, Tania Rozario, Umair W Khan, Rosa Mejia-Sanchez, Sylvain W Lapan, Peter W Reddien, Phillip A Newmark
Publikováno v:
PLoS Biology, Vol 20, Iss 7, p e3001472 (2022)
Sexually reproducing animals segregate their germline from their soma. In addition to gamete-producing gonads, planarian and parasitic flatworm reproduction relies on yolk cell-generating accessory reproductive organs (vitellaria) supporting developm
Externí odkaz:
https://doaj.org/article/b782261626db44e78acdf304854ec834
Publikováno v:
eLife, Vol 9 (2020)
Proper function and repair of the digestive system are vital to most animals. Deciphering the mechanisms involved in these processes requires an atlas of gene expression and cell types. Here, we applied laser-capture microdissection (LCM) and RNA-seq
Externí odkaz:
https://doaj.org/article/ff49e0917861474d8325cb12398203a9
Autor:
Jiarong Gao, Ning Yang, Fred A Lewis, Peter Yau, James J Collins, Jonathan V Sweedler, Phillip A Newmark
Publikováno v:
PLoS Biology, Vol 17, Iss 10, p e3000485 (2019)
Schistosomes are parasitic flatworms that infect over 200 million people, causing the neglected tropical disease, schistosomiasis. A single drug, praziquantel, is used to treat schistosome infection. Limitations in mass drug administration programs a
Externí odkaz:
https://doaj.org/article/d562f634e428434e90cb5ac4de6f9c80
Publikováno v:
eLife, Vol 8 (2019)
Tapeworms grow at rates rivaling the fastest-growing metazoan tissues. To propagate they shed large parts of their body; to replace these lost tissues they regenerate proglottids (segments) as part of normal homeostasis. Their remarkable growth and r
Externí odkaz:
https://doaj.org/article/4e42654e7ffe452ebabe5752e4b98af0
Autor:
Amir Saberi, Anastasia A Gulyaeva, John L Brubacher, Phillip A Newmark, Alexander E Gorbalenya
Publikováno v:
PLoS Pathogens, Vol 14, Iss 11, p e1007314 (2018)
RNA viruses are the only known RNA-protein (RNP) entities capable of autonomous replication (albeit within a permissive host environment). A 33.5 kilobase (kb) nidovirus has been considered close to the upper size limit for such entities; conversely,
Externí odkaz:
https://doaj.org/article/8e6799ff2957418e89027d02e3735803
Autor:
Bo Wang, Jayhun Lee, Pengyang Li, Amir Saberi, Huiying Yang, Chang Liu, Minglei Zhao, Phillip A Newmark
Publikováno v:
eLife, Vol 7 (2018)
Schistosomes are parasitic flatworms infecting hundreds of millions of people. These parasites alternate between asexual reproduction in molluscan hosts and sexual reproduction in mammalian hosts; short-lived, water-borne stages infect each host. Thr
Externí odkaz:
https://doaj.org/article/a77c5eb491144b9fa12bf354ff58c680
Publikováno v:
eLife, Vol 5 (2016)
Planarians regenerate all body parts after injury, including the central nervous system (CNS). We capitalized on this distinctive trait and completed a gene expression-guided functional screen to identify factors that regulate diverse aspects of neur
Externí odkaz:
https://doaj.org/article/a7fd44166fbe434ca66b1671cf18c8ae
Publikováno v:
PLoS Genetics, Vol 12, Iss 6, p e1006109 (2016)
Gametes are the source and carrier of genetic information, essential for the propagation of all sexually reproducing organisms. Male gametes are derived from a progenitor stem cell population called spermatogonial stem cells (SSCs). SSCs give rise to
Externí odkaz:
https://doaj.org/article/dd9edf36e8b24589b0295d707dd6d5da
Publikováno v:
PLoS Biology, Vol 14, Iss 5, p e1002457 (2016)
Planarians display remarkable plasticity in maintenance of their germline, with the ability to develop or dismantle reproductive tissues in response to systemic and environmental cues. Here, we investigated the role of G protein-coupled receptors (GP
Externí odkaz:
https://doaj.org/article/735acbff35d644f0a91afa7235f15d11
Publikováno v:
eLife, Vol 5 (2016)
Schistosomes infect more than 200 million of the world's poorest people. These parasites live in the vasculature, producing eggs that spur a variety of chronic, potentially life-threatening, pathologies exacerbated by the long lifespan of schistosome
Externí odkaz:
https://doaj.org/article/f72d1c7116a0469885544848f5154bc8