Zobrazeno 1 - 10
of 265
pro vyhledávání: '"Phillip, Scott"'
Autor:
Laís Amorim Sacramento, Camila Farias Amorim, Claudia G Lombana, Daniel Beiting, Fernanda Novais, Lucas P Carvalho, Edgar M Carvalho, Phillip Scott
Publikováno v:
PLoS Pathogens, Vol 20, Iss 5, p e1012211 (2024)
Cytolytic CD8+ T cells mediate immunopathology in cutaneous leishmaniasis without controlling parasites. Here, we identify factors involved in CD8+ T cell migration to the lesion that could be targeted to ameliorate disease severity. CCR5 was the mos
Externí odkaz:
https://doaj.org/article/7117dd5863ba4854bd15cc637e19d37d
Autor:
Fabio C. Peixoto, Dalila L. Zanette, Thiago M. Cardoso, Mauricio T. Nascimento, Rodrigo C. O. Sanches, Mateus Aoki, Phillip Scott, Sérgio C. Oliveira, Edgar M. Carvalho, Lucas P. Carvalho
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Exosomes, organelles measuring 30-200nm, are secreted by various cell types. Leishmania exosomes consist of many proteins, including heat shock proteins, annexins, Glycoprotein 63, proteins exerting signaling activity and those containing mRNA and mi
Externí odkaz:
https://doaj.org/article/ca668565b48c40999512c64667417efa
Autor:
Laís A Sacramento, Camila Farias Amorim, Taís M Campos, Maíra Saldanha, Sérgio Arruda, Lucas P Carvalho, Daniel P Beiting, Edgar M Carvalho, Fernanda O Novais, Phillip Scott
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 8, p e0011552 (2023)
Cutaneous leishmaniasis exhibits a spectrum of clinical presentations dependent upon the parasites' persistence and host immunopathologic responses. Although cytolytic CD8 T cells cannot control the parasites, they significantly contribute to patholo
Externí odkaz:
https://doaj.org/article/e0207c6016624022a4aa50a9a9f1c4c6
Autor:
Augusto M. Carvalho, Rúbia S. Costa, Alexsandro Lago, Olívia Bacellar, Daniel P. Beiting, Phillip Scott, Lucas P. Carvalho, Edgar M. Carvalho
Publikováno v:
Pathogens, Vol 13, Iss 3, p 199 (2024)
The role of the immune response in the pathogenesis of cutaneous leishmaniasis (CL) due to Leishmania (Viannia) braziliensis is predominantly carried out via blood cells. Here, we evaluate whether cytokine production by peripheral blood mononuclear c
Externí odkaz:
https://doaj.org/article/bc1f5a81c16d476faa0d2b06154d6cba
Autor:
Olivia A Pilling, João L Reis-Cunha, Cooper A Grace, Alexander S F Berry, Matthew W Mitchell, Jane A Yu, Clara R Malekshahi, Elise Krespan, Christina K Go, Cláudia Lombana, Yun S Song, Camila F Amorim, Alexsandro S Lago, Lucas P Carvalho, Edgar M Carvalho, Dustin Brisson, Phillip Scott, Daniel C Jeffares, Daniel P Beiting
Publikováno v:
PLoS Pathogens, Vol 19, Iss 3, p e1011230 (2023)
In Brazil, Leishmania braziliensis is the main causative agent of the neglected tropical disease, cutaneous leishmaniasis (CL). CL presents on a spectrum of disease severity with a high rate of treatment failure. Yet the parasite factors that contrib
Externí odkaz:
https://doaj.org/article/737717bbee8b47e590ec22cd8859a3a4
Autor:
Maurício T. Nascimento, Mônica Franca, Augusto M. Carvalho, Camila F. Amorim, Fábio Peixoto, Daniel Beiting, Phillip Scott, Edgar M. Carvalho, Lucas P. Carvalho
Publikováno v:
Emerging Microbes and Infections, Vol 10, Iss 1, Pp 1219-1226 (2021)
Cutaneous leishmaniasis (CL) patients present an exacerbated inflammatory response associated with tissue damage and ulcer development. Increasing numbers of patients have exhibited treatment failure, which remains not well understood. We hypothesize
Externí odkaz:
https://doaj.org/article/c6776a6013094b0f9a9f74631dfc5f06
Autor:
Tej Pratap Singh, Augusto M. Carvalho, Laís Amorim Sacramento, Elizabeth A. Grice, Phillip Scott
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10 (2021)
Innate lymphoid cells (ILCs) comprise a heterogeneous population of immune cells that maintain barrier function and can initiate a protective or pathological immune response upon infection. Here we show the involvement of IL-17A-producing ILCs in mic
Externí odkaz:
https://doaj.org/article/7ddcb0ee5bb542fc8a2a2376d23e4dcb
Autor:
Camila Farias Amorim, Fernanda O Novais, Ba T Nguyen, Mauricio T Nascimento, Jamile Lago, Alexsandro S Lago, Lucas P Carvalho, Daniel P Beiting, Phillip Scott
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 4, p e0009321 (2021)
Cutaneous leishmaniasis is a localized infection controlled by CD4+ T cells that produce IFN-γ within lesions. Phagocytic cells recruited to lesions, such as monocytes, are then exposed to IFN-γ which triggers their ability to kill the intracellula
Externí odkaz:
https://doaj.org/article/831669485c7f4f5a89de9e4a4de5a7b9
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Cutaneous leishmaniasis exhibits a wide spectrum of clinical presentations from self-resolving infections to severe chronic disease. Anti-parasitic drugs are often ineffective in the most severe forms of the disease, and in some cases the magnitude o
Externí odkaz:
https://doaj.org/article/fc582bdbc9d7475cbc1c603aff8f0e21