Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Phillip, Chumley"'
Autor:
Mary Claire Doss, Sean Mullen, Ronald Roye, Juling Zhou, Phillip Chumley, Elias Mrug, Darren P. Wallace, Feng Qian, Peter C. Harris, Bradley K. Yoder, Harrison Kim, Michal Mrug
Publikováno v:
American Journal of Physiology-Renal Physiology. 324:F423-F430
Total kidney volume (TKV) is a valuable readout in preclinical studies for autosomal dominant and autosomal recessive polycystic kidney diseases (ADPKD and ARPKD). Since conventional TKV assessment by manual contouring of kidney areas in all images i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbb4aca665b03f77422297186a9e127f
https://doi.org/10.1152/ajprenal.00295.2022
https://doi.org/10.1152/ajprenal.00295.2022
Autor:
Zhang, Li, Kurt A, Zimmerman, Sreelakshmi, Cherakara, Phillip, Chumley, James F, Collawn, Jun, Wang, Courtney J, Haycraft, Cheng J, Song, Teresa, Chacana, Reagan S, Andersen, Mandy J, Croyle, Ernald J, Aloria, Raksha P, Hombal, Isis N, Thomas, Hanan, Chweih, Kristin L, Simanyi, James F, George, John M, Parant, Michal, Mrug, Bradley K, Yoder
Publikováno v:
Disease modelsmechanisms.
Although renal macrophages have been shown to contribute to cystic kidney disease in PKD animal models, it remains unclear if there is a specific macrophage subpopulation involved. Here we analyze changes in macrophage populations during renal matura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e51519d9aa52e146d5ab89ff523e80cb
https://pubmed.ncbi.nlm.nih.gov/36457161
https://pubmed.ncbi.nlm.nih.gov/36457161
Autor:
Dustin Z. Revell, Sean Mullen, Trenton R. Schoeb, Lisa M. Guay-Woodford, Harrison Kim, Dan Shan, Mark E. Lockhart, Mandy J. Croyle, Juling Zhou, Anil K. Challa, Phillip Chumley, Bradley K. Yoder, Gabriel Rezonzew, Robert A. Kesterson, Ronald Roye, Michal Mrug
Publikováno v:
American Journal of Physiology-Renal Physiology. 316:F463-F472
Heterozygosity for human polycystic kidney and hepatic disease 1 ( PKHD1) mutations was recently associated with cystic liver disease and radiographic findings resembling medullary sponge kidney (MSK). However, the relevance of these associations has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd3c733982ca2a3825bc247f19374cc8
https://doi.org/10.1152/ajprenal.00181.2018
https://doi.org/10.1152/ajprenal.00181.2018
Autor:
Ping Hua, Edgar A. Jaimes, Mikhail Y. Golovko, Wenguang Feng, Huma Fatima, Phillip Chumley, Sunil Rangarajan, Gabriel Rezonzew
Publikováno v:
Am J Physiol Renal Physiol
Tobacco smoking has been identified as a risk factor in the progression of chronic kidney disease (CKD). In previous studies, we showed that nicotine induces cyclooxygenase (COX)-2 expression in vivo and in vitro and that the administration of nicoti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb9def12dcc1b97bbf06f20754a15a5
https://pubmed.ncbi.nlm.nih.gov/31841390
https://pubmed.ncbi.nlm.nih.gov/31841390
Autor:
Sylvie Mrug, Victor M. Darley-Usmar, P. Darwin Bell, Phillip Chumley, Stephen Barnes, Bradley K. Yoder, Anil K. Challa, Taylor F. Berryhill, Balu K. Chacko, Landon Wilson, Robert A. Kesterson, Juling Zhou, John M. Parant, Michal Mrug
Publikováno v:
American journal of physiology. Renal physiology. 316(3)
Deficiency in polycystin 1 triggers specific changes in energy metabolism. To determine whether defects in other human cystoproteins have similar effects, we studied extracellular acidification and glucose metabolism in human embryonic kidney (HEK-29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::215231a01f4e28cd2fedaed03ab0a24a
https://pubmed.ncbi.nlm.nih.gov/30566001
https://pubmed.ncbi.nlm.nih.gov/30566001
Autor:
Teresa Chacana, Phillip Chumley, Laurie E. Harrington, Kurt A. Zimmerman, Michal Mrug, Nancy M. Gonzalez, Bradley K. Yoder
Publikováno v:
Physiological Reports
Several innate immune response components were recognized as outcome predictors in autosomal dominant polycystic kidney disease (ADPKD) and their causative role in disease pathogenesis was confirmed in animal models. In contrast, the role of adaptive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b345ab3b8e400450ef3f79629615425
https://pubmed.ncbi.nlm.nih.gov/30632307
https://pubmed.ncbi.nlm.nih.gov/30632307
Autor:
David W. Scott, Rakesh P. Patel, Michael Allon, Wenguang Feng, Edgar A. Jaimes, James N. George, Phillip Chumley, Silvio H. Litovsky
Publikováno v:
Journal of the American Society of Nephrology. 25:475-487
Hemodialysis vascular access dysfunction contributes to increased morbidity and mortality in hemodialysis patients. Arteriovenous fistula (AVF) is the preferred type of vascular access for hemodialysis but has high rates of dysfunction, in part becau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3742073cb28688c7730a615516002f1
https://doi.org/10.1681/asn.2013040424
https://doi.org/10.1681/asn.2013040424
Publikováno v:
American Journal of Kidney Diseases. 61:1026-1031
Since the introduction of imatinib, tyrosine kinase inhibition has been a mainstay in the treatment of many malignancies. The number of these medications is growing, as are the number of targeted tyrosine kinases. Off-target effects of these medicati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beee2074f8b4dc4c7c963397b9ece872
https://doi.org/10.1053/j.ajkd.2013.01.022
https://doi.org/10.1053/j.ajkd.2013.01.022
Publikováno v:
American Journal of Physiology-Renal Physiology. 302:F1418-F1429
Angiotensin II (ANG II) produced as result of activation of the renin-angiotensin system (RAS) plays a critical role in the pathogenesis of chronic kidney disease via its hemodynamic effects on the renal microcirculation as well as by its nonhemodyna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd4479c0cc310bc146512c1e598c807
https://doi.org/10.1152/ajprenal.00477.2011
https://doi.org/10.1152/ajprenal.00477.2011
Autor:
Bo Chen, Liliana Viera, David K. Crossman, Angela Brandon, Xinjun Teng, Brett D. Yancey, Molly S. Bray, John A. Thompson, Anupam Agarwal, Stacey S. Kelpke, Kelley M. Bradley, Rakesh P. Patel, Devin E. Eckhoff, Brandon Moore, Phillip Chumley, Hughston Head
Publikováno v:
Kidney international
Renal injury induced by brain death is characterized by ischemia and inflammation, and limiting it is a therapeutic goal that could improve outcomes in kidney transplantation. Brain death resulted in decreased circulating nitrite levels and increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c834721f2a0d81fc3b747fbba0f40e
http://europepmc.org/articles/PMC3412933
http://europepmc.org/articles/PMC3412933