Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Philippe Rondard"'
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract G protein-coupled receptors naturally oscillate between inactive and active states, often resulting in receptor constitutive activity with important physiological consequences. Among the class C G protein-coupled receptors that typically sen
Externí odkaz:
https://doaj.org/article/9edd1bb4b2fc481a80983bffca4b41c7
Autor:
Chanjuan Xu, Yiwei Zhou, Yuxuan Liu, Li Lin, Peng Liu, Xiaomei Wang, Zhengyuan Xu, Jean-Philippe Pin, Philippe Rondard, Jianfeng Liu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract G protein-coupled receptors (GPCRs) constitute the largest family of membrane proteins and are important drug targets. The discovery of drugs targeting these receptors and their G protein signaling properties are based on assays mainly perfo
Externí odkaz:
https://doaj.org/article/85a6b4f2dd3241fba99b3d3521990c96
Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor
Autor:
Junke Liu, Hengmin Tang, Chanjuan Xu, Shengnan Zhou, Xunying Zhu, Yuanyuan Li, Laurent Prézeau, Tao Xu, Jean-Philippe Pin, Philippe Rondard, Wei Ji, Jianfeng Liu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The functional consequence of G protein-coupled receptor oligomerization remains debated. Here the authors show that platelet-activating factor receptor oligomerization enhances G protein coupling, and restrains β-arrestin recruitment and internaliz
Externí odkaz:
https://doaj.org/article/a97813f6a8c84e5398c5ec28ca06bef1
Autor:
Pascal Dominic Rem, Vita Sereikaite, Diego Fernández-Fernández, Sebastian Reinartz, Daniel Ulrich, Thorsten Fritzius, Luca Trovo, Salomé Roux, Ziyang Chen, Philippe Rondard, Jean-Philippe Pin, Jochen Schwenk, Bernd Fakler, Martin Gassmann, Tania Rinaldi Barkat, Kristian Strømgaard, Bernhard Bettler
Publikováno v:
eLife, Vol 12 (2023)
Amyloid-β precursor protein (APP) regulates neuronal activity through the release of secreted APP (sAPP) acting at cell surface receptors. APP and sAPP were reported to bind to the extracellular sushi domain 1 (SD1) of GABAB receptors (GBRs). A 17 a
Externí odkaz:
https://doaj.org/article/f48ea31c4d5245788aa36e87dccbb8c4
Autor:
Anne-Marinette Cao, Robert B. Quast, Fataneh Fatemi, Philippe Rondard, Jean-Philippe Pin, Emmanuel Margeat
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Here, the authors use smFRET to assess the structural dynamics of metabotropic glutamate receptor mGlu2 and show that a positive allosteric modulator or the Gi protein stabilize mGlu2 in the glutamate-induced active state, leading to the full activat
Externí odkaz:
https://doaj.org/article/a14531ed08b24689ae4bc18c982d5788
Autor:
Mireille Elodie Tsitokana, Pierre-André Lafon, Laurent Prézeau, Jean-Philippe Pin, Philippe Rondard
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2632 (2023)
Treatments for central nervous system diseases with therapeutic antibodies have been increasingly investigated over the last decades, leading to some approved monoclonal antibodies for brain disease therapies. The detection of biomarkers for diagnosi
Externí odkaz:
https://doaj.org/article/5b6cddb357dd419e97960d36725e317d
Autor:
Lei Liu, Zhiran Fan, Xavier Rovira, Li Xue, Salomé Roux, Isabelle Brabet, Mingxia Xin, Jean-Philippe Pin, Philippe Rondard, Jianfeng Liu
Publikováno v:
eLife, Vol 10 (2021)
G protein-coupled receptors (GPCRs) are among the most promising drug targets. They often form homo- and heterodimers with allosteric cross-talk between receptor entities, which contributes to fine-tuning of transmembrane signaling. Specifically cont
Externí odkaz:
https://doaj.org/article/637406475b8f4911855cad59cb27a13c
Autor:
Bo Wei, Yini Zhu, Peng Yang, Yong Han, Suyun Wang, Xiaomei Wang, Shuai Xia, Xiaoguang Song, Zhongling Zhang, Sheng Wang, Philippe Rondard, Jean-Philippe Pin, Xinnong Jiang, Jianfeng Liu
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103311- (2021)
Summary: Neurotransmitter receptors are involved in cancer progression. Among them, the heterodimeric GABAB receptor, activated by the main inhibitory neurotransmitter GABA, is composed of the transmembrane GABAB1 and GABAB2 subunits. The oncogenic r
Externí odkaz:
https://doaj.org/article/c8be0a9624c74e0fa5a997cc31a09980
Autor:
Li Xue, Qian Sun, Han Zhao, Xavier Rovira, Siyu Gai, Qianwen He, Jean-Philippe Pin, Jianfeng Liu, Philippe Rondard
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
G protein-coupled receptors (GPCRs), such as GABAB, can integrate extracellular signals via allosteric interactions within dimers and oligomers. Here authors use crosslinking and identify two transmembrane interfaces in GABAB which undergo a concerte
Externí odkaz:
https://doaj.org/article/2a62f546d82a4973a65a19204b56e900
Autor:
Pauline Scholler, Damien Nevoltris, Dimitri de Bundel, Simon Bossi, David Moreno-Delgado, Xavier Rovira, Thor C. Møller, Driss El Moustaine, Michaël Mathieu, Emilie Blanc, Heather McLean, Elodie Dupuis, Gérard Mathis, Eric Trinquet, Hervé Daniel, Emmanuel Valjent, Daniel Baty, Patrick Chames, Philippe Rondard, Jean-Philippe Pin
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
G protein-coupled receptors are considered promising therapeutic targets. Here, the authors have identified nanobodies, or single-domain llama antibodies, that specifically enhance agonist-induced activity of a type of G protein-coupled receptor, the
Externí odkaz:
https://doaj.org/article/816648732d614ed3bfb0746f18dd9438