Protein dynamics at invadopodia control invasion–migration transitions in melanoma cells

Autor: Marlène Legrand, Antoine Mousson, Philippe Carl, Léa Rossé, Hélène Justiniano, Jean-Pierre Gies, Daniel Bouvard, Emilie Sick, Denis Dujardin, Philippe Rondé

Publikováno v: Cell Death and Disease, Vol 14, Iss 3, Pp 1-15 (2023)

Abstract Cell invasion is a highly complex process that requires the coordination of cell migration and degradation of the extracellular matrix. In melanoma cells, as in many highly invasive cancer cell types these processes are driven by the regulat

Externí odkaz: https://doaj.org/article/bbce99f838bc44cfb35b5e3cd745d704

Investigating the cellular distribution and interactions of HIV-1 nucleocapsid protein by quantitative fluorescence microscopy.

Autor: Halina Anton, Nedal Taha, Emmanuel Boutant, Ludovic Richert, Heena Khatter, Bruno Klaholz, Philippe Rondé, Eléonore Réal, Hugues de Rocquigny, Yves Mély

Publikováno v: PLoS ONE, Vol 10, Iss 2, p e0116921 (2015)

The nucleocapsid protein (NCp7) of the Human immunodeficiency virus type 1 (HIV-1) is a small basic protein containing two zinc fingers. About 2000 NCp7 molecules coat the genomic RNA in the HIV-1 virion. After infection of a target cell, the viral c

Externí odkaz: https://doaj.org/article/e5220d7aff864e33bc63dc204de9be70

Occludin stalls HCV particle dynamics apart from hepatocyte tight junctions, promoting virion internalization

Autor: Maika S. Deffieu, Camille M. H Clément, Cristina M. Dorobantu, Emma Partiot, Yonis Bare, Orestis Faklaris, Benjamin Rivière, Nilda Vanesa Ayala‐Nunez, Thomas F. Baumert, Philippe Rondé, Yves Mély, Vincent Lucansky, Raphael Gaudin

Publikováno v: Hepatology
Hepatology, inPress, pp.1164-1179. ⟨10.1002/hep.32514⟩

International audience; Background and Aims: Numerous HCV entry factors have been identified, and yet information regarding their spatiotemporal dynamics is still limited. Specifically, one of the main entry factors of HCV is occludin (OCLN), a prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6087e758d65f66096c4121883c8fffbf
https://pubmed.ncbi.nlm.nih.gov/35388524

Role of Endocytosis Proteins in Gefitinib-Mediated EGFR Internalisation in Glioma Cells

Autor: Lehmann, Elisabete Cruz Da Silva, Laurence Choulier, Jessica Thevenard-Devy, Christophe Schneider, Philippe Carl, Philippe Rondé, Stéphane Dedieu, Maxime

Publikováno v: Cells; Volume 10; Issue 11; Pages: 3258

EGFR (epidermal growth factor receptor), a member of the ErbB tyrosine kinase receptor family, is a clinical therapeutic target in numerous solid tumours. EGFR overexpression in glioblastoma (GBM) drives cell invasion and tumour progression. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::30da0a2e70df8f155ff9dcfe6b1379f5

Characterisation of endogenous Claudin‐1 expression, motility and susceptibility to hepatitis C virus in CRISPR knock‐in cells

Autor: Yves Mély, Cristina M. Dorobantu, Philippe Rondé, Nilda Vanesa Ayala-Nunez, Camille M.H. Clément, Thomas F. Baumert, Raphael Gaudin, Maika S. Deffieu

Publikováno v: Biology of the Cell
Biology of the Cell, Wiley, 2020, 112 (5), pp.140-151. ⟨10.1111/boc.201900085⟩
Biology of the Cell, 2020, 112 (5), pp.140-151. ⟨10.1111/boc.201900085⟩
Biol Cell

Claudin-1 (CLDN1) is a four-span transmembrane protein localised at cell-cell tight junctions (TJs), playing an important role in epithelial impermeability and tissue homoeostasis under physiological conditions. Moreover, CLDN1 expression is up-regul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee8fd12110f94491623287ff71b37fe