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Autor:
Judith Marfurt, Florence Philippoz, Frédéric Lallemand, Philippe Perottet, Werner Kloeti, Kamel Besseghir, Olivia Felt-Baeyens, Robert Gurny
Publikováno v:
European Journal of Pharmaceutical Sciences, Vol. 26, No 1 (2005) pp. 124-129
UNIL088 is a water-soluble prodrug of cyclosporine A (CsA) developed for topical eye delivery. Such a prodrug has to fulfil two paradoxical requirements as it must be rapidly hydrolysed under physiological conditions but also retain a long shelf-life