Pathobiological features of a novel, highly pathogenic avian influenza A(H5N8) virus

Autor: Young-Il Kim, Philippe Noriel Q Pascua, Hyeok-Il Kwon, Gyo-Jin Lim, Eun-Ha Kim, Sun-Woo Yoon, Su-Jin Park, Se Mi Kim, Eun-Ji Choi, Young-Jae Si, Ok-Jun Lee, Woo-Sub Shim, Si-Wook Kim, In-Pil Mo, Yeonji Bae, Yong Taik Lim, Moon Hee Sung, Chul-Joong Kim, Richard J Webby, Robert G Webster, Young Ki Choi

Publikováno v: Emerging Microbes and Infections, Vol 3, Iss 1, Pp 1-13 (2014)

The endemicity of highly pathogenic avian influenza (HPAI) A(H5N1) viruses in Asia has led to the generation of reassortant H5 strains with novel gene constellations. A newly emerged HPAI A(H5N8) virus caused poultry outbreaks in the Republic of Kore

Externí odkaz: https://doaj.org/article/8361fab7e9bc4732a56fc535bfe95edd

Evaluation of the efficacy and cross-protectivity of recent human and swine vaccines against the pandemic (H1N1) 2009 virus infection.

Autor: Philippe Noriel Q Pascua, Min-Suk Song, Jun Han Lee, Kuk Jin Park, Hyeok-Il Kwon, Yun Hee Baek, Seung-Pyo Hong, Jong-Bok Rho, Chul-Joong Kim, Haryoung Poo, Thomas S Ryoo, Moon-Hee Sung, Young Ki Choi

Publikováno v: PLoS ONE, Vol 4, Iss 12, p e8431 (2009)

The current pandemic (H1N1) 2009 virus remains transmissible among humans worldwide with cases of reverse zoonosis, providing opportunities to produce more pathogenic variants which could pose greater human health concerns. To investigate whether rec

Externí odkaz: https://doaj.org/article/c08c7a5be5c84f6fb01433283c64e1e4

Multiple polymerase acidic (PA) I38X substitutions in influenza A(H1N1)pdm09 virus permit polymerase activity and cause reduced baloxavir inhibition

Autor: Walter N. Harrington, Jeremy C. Jones, Philippe Noriel Q. Pascua, Elena A. Govorkova, Richard J. Webby

Publikováno v: J Antimicrob Chemother

Background Baloxavir marboxil is an antiviral drug that targets the endonuclease activity of the influenza virus polymerase acidic (PA) protein. PA I38T/M/F substitutions reduce its antiviral efficacy. Objectives To understand the effects of the 19 p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209ab717795461df9dfae21bd09b66c0
https://doi.org/10.1093/jac/dkaa527

Resurrected ancestral influenza A viruses recapitulate the avian-to-mammalian adaptation of European avian-like swine influenza virus

Autor: Yuqin Zhang, Lisa Kercher, Yue Ji, John Franks, Jennifer DeBeauchamp, Jayanthi Jayakumar, Robert G. Webster, Michael Cw Chan, Christine H T Bui, Kristien Van Reeth, Adam Rubrum, Chung-Yi Wu, Christina Kackos, Rhodri Harfoot, Jeri-Carol Crumpton, Richard J. Webby, Wen Su, Yvonne C. F. Su, Udayan Joseph, Scott Krauss, Trushar Jeevan, Jeremy C. Jones, Philippe Noriel Q. Pascua, Mengting Zhang, Hui-Ling Yen, Malik Peiris, Stephan Pleschka, Gavin J. D. Smith

The emergence of a pandemic influenza virus may be better anticipated if we better understand the evolutionary steps taken by avian influenza viruses as they adapt to mammals. We used ancestral sequence reconstruction to resurrect viruses representin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76052c874bc9a1f5460970ad03da6a64
https://doi.org/10.21203/rs.3.rs-436907/v1

Characterizing Emerging Canine H3 Influenza Viruses

Autor: Huihui Kong, Laura Rodriguez, Brian R. Wasik, Hanyuan Zhang, Guojun Wang, Yoshihiro Kawaoka, Kuan-Fu Chen, Pamela Freiden, Nicholas Wohlgemuth, David F. Burke, Ashley L. Fink, Sabra L. Klein, Melissa B. Uccellini, Patrick C. Wilson, Karlie Woodard, Sander Herfst, David J. Topham, Angela Danner, Zhen-Ying Liu, Daniel R. Perez, Cheryl A. Jones, John Steel, Philippe Noriel Q. Pascua, Christopher S. Anderson, Anice C. Lowen, Katherine J. Fenstermacher, Lauren Sauer, Victoria A. Meliopoulos, Jeanne Holden-Wiltse, Richard D. Cummings, Yao-Tsun Li, Gabriele Neumann, Malik Peiris, Elena A. Govorkova, Kaori Sakamoto, Michael C. W. Chan, Derek J. Smith, Benjamin L. Miller, Sanjukta Bandyopadhyay, Colin R. Parrish, Subrata Barman, John J. Treanor, Lucas M. Ferreri, Shamika Danzy, Hui Tao, Ian E. H. Voorhees, Ranawaka A.P.M. Perera, Paul G. Thomas, Scott Krauss, David A. Steinhauer, Adolfo García-Sastre, Pilar Blanco-Lobo, Gavin J. D. Smith, Stacey Schultz-Cherry, Phuong T. M. Nguyen, Luis Martinez-Sobrido, Ron A. M. Fouchier, Masato Hatta, Sean Cherry, Brandi Livingston, Marta L. DeDiego, Gongxun Zhong, Mathilde Richard, David J. Pattinson, Mitra Lewis, Bridgett Sharp, Farah El Najjar, Andrew Pekosz, Jasmina M. Luczo, Stephen M. Tompkins, Charles J. Russell, Bindumadhav M. Marathe, Richard E. Rothman, Carole Henry, Lauren Byrd-Leotis, Mark Y. Sangster, Theresa Fitzgerald, Juan Carlos Dib, Shiho Chiba, Shufang Fan, Kathryn Shaw-Saliba, Aitor Nogales, Guohua Yang, Richard J. Webby

Publikováno v: PLoS Pathogens (print), 16(4). Public Library of Science
PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 4, p e1008409 (2020)

The continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify strains that may pose a human public health risk. Since 1999, canine H3 influenza A viruses (CIVs) hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17cacbabdb58d1c8f6de8ace50f09b62
https://pure.eur.nl/en/publications/1b3e08ab-97d9-478a-b557-32004ce55257