Výsledky vyhledávání - "Philippe M Hauser"

Determination of the precise composition and variation of microbiota in cystic fibrosis lungs is crucial since chronic inflammation due to microorganisms leads to lung damage and ultimately, death. However, this constitutes a major technical challeng

Externí odkaz: https://doaj.org/article/42947bd093504a01a07a06975b1fdee5

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Akademický článek

Comparative genomics suggests that the fungal pathogen pneumocystis is an obligate parasite scavenging amino acids from its host's lungs.

Autor: Philippe M Hauser, Frédéric X Burdet, Ousmane H Cissé, Laurent Keller, Patrick Taffé, Dominique Sanglard, Marco Pagni

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e15152 (2010)

Pneumocystis jirovecii is a fungus causing severe pneumonia in immuno-compromised patients. Progress in understanding its pathogenicity and epidemiology has been hampered by the lack of a long-term in vitro culture method. Obligate parasitism of this

Externí odkaz: https://doaj.org/article/9686b20b316f4de4b85c9c16896d9feb

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Akademický článek

Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes’ repertoires

Autor: Caroline S. Meier, Marco Pagni, Sophie Richard, Konrad Mühlethaler, João M. G. C. F. Almeida, Gilles Nevez, Melanie T. Cushion, Enrique J. Calderón, Philippe M. Hauser

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Abstract Surface antigenic variation is crucial for major pathogens that infect humans. To escape the immune system, they exploit various mechanisms. Understanding these mechanisms is important to better prevent and fight the deadly diseases caused.

Externí odkaz: https://doaj.org/article/38540847963544e585f51e93cfe07bc9

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Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes’ repertoires, potentially mediated by DNA triplexes

Autor: Caroline S. Meier, Marco Pagni, Sophie Richard, Konrad Mühlethaler, Joao M. G. C. F. Almeida, Gilles Nevez, Melanie T. Cushion, Enrique J. Calderón, Philippe M. Hauser

Surface antigenic variation is crucial for major pathogens that infect humans, e.g.Plasmodium1,Trypanosoma2,Giardia3. In order to escape the immune system, they exploit various mechanisms in order to modify or exchange the protein that is exposed on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68d9a77c6e1667bddb63004a0abde6ad
https://doi.org/10.1101/2023.03.21.533526

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Anidulafungin Treatment Blocks the Sexual Cycle of Pneumocystis murina and Prevents Growth and Survival without Rescue by an Alternative Mode of Replication

Autor: Melanie T. Cushion, Alan Ashbaugh, Steven G. Sayson, Christopher Mosley, Philippe M. Hauser

Publikováno v: Microbiology spectrum. 10(6)

The proposed life cycle of fungi in the genus Pneumocystis has typically included both an asexual cycle via binary fission and a sexual cycle. Until recently, the strategy used for sexual replication was largely unknown, but genomic and functional as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d8b837e1101ba3c11969348e664df32
https://pubmed.ncbi.nlm.nih.gov/36287071

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