Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Philippe Lory"'
Autor:
Sophie Nicole, Philippe Lory
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The voltage-gated sodium channel Nav1.4 is a major actor in the excitability of skeletal myofibers, driving the muscle force in response to nerve stimulation. Supporting further this key role, mutations in SCN4A, the gene encoding the pore-forming α
Externí odkaz:
https://doaj.org/article/cd26fe232053492e965ac2fe462155f6
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Abstract The excitability of neurons is tightly dependent on their ion channel repertoire. Among these channels, the leak sodium channel NALCN plays a crucial role in the maintenance of the resting membrane potential. Importantly, NALCN mutations lea
Externí odkaz:
https://doaj.org/article/dcd140aae78142bb86ff1ce05531546b
Autor:
Kevin Dorgans, Julie Salvi, Federica Bertaso, Ludivine Bernard, Philippe Lory, Frederic Doussau, Alexandre Mezghrani
Publikováno v:
Neurobiology of Disease, Vol 106, Iss , Pp 110-123 (2017)
Episodic Ataxia type 2 (EA2) is an autosomal dominant neuronal disorder linked to mutations in the Cav2.1 subunit of P/Q-type calcium channels. In vitro studies have established that EA2 mutations induce loss of channel activity and that EA2 mutants
Externí odkaz:
https://doaj.org/article/95d27118ac764f4fa5133ffc2df69352
Autor:
Georgios Daniil, Fabio L Fernandes-Rosa, Jean Chemin, Iulia Blesneac, Jacques Beltrand, Michel Polak, Xavier Jeunemaitre, Sheerazed Boulkroun, Laurence Amar, Tim M Strom, Philippe Lory, Maria-Christina Zennaro
Publikováno v:
EBioMedicine, Vol 13, Iss C, Pp 225-236 (2016)
Primary aldosteronism (PA) is the most common form of secondary hypertension. Mutations in KCNJ5, ATP1A1, ATP2B3 and CACNA1D are found in aldosterone producing adenoma (APA) and familial hyperaldosteronism (FH). A recurrent mutation in CACNA1H (codin
Externí odkaz:
https://doaj.org/article/20885624f70b4804b4dab14371e31714
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186864 (2017)
Medicinal plants represent a significant reservoir of unexplored substances for early-stage drug discovery. Of interest, two flowering Mediterranean plants have been used for thousands of years for their beneficial effects on nervous disorders, inclu
Externí odkaz:
https://doaj.org/article/3f46162092304310be97ee58a1adbc1e
Publikováno v:
eLife, Vol 6 (2017)
Voltage-gated Ca2+ channels are involved in numerous physiological functions and various mechanisms finely tune their activity, including the Ca2+ ion itself. This is well exemplified by the Ca2+-dependent inactivation of L-type Ca2+ channels, whose
Externí odkaz:
https://doaj.org/article/0fd9dfd2809a49318f11a36717ac3ca2
Autor:
Julie Salvi, Federica Bertaso, Anne-Laure Mausset-Bonnefont, Alexandra Metz, Céline Lemmers, Fabrice Ango, Laurent Fagni, Philippe Lory, Alexandre Mezghrani
Publikováno v:
Neurobiology of Disease, Vol 68, Iss , Pp 47-56 (2014)
Episodic ataxia type-2 (EA2) is a dominantly inherited human neurological disorder caused by loss of function mutations in the CACNA1A gene, which encodes the CaV2.1 subunit of P/Q-type voltage-gated calcium channels. It remains however unknown wheth
Externí odkaz:
https://doaj.org/article/134a4839fbb746e09ea46831f9f608f2
Autor:
Joel P Baumgart, Iuliia Vitko, Isabelle Bidaud, Artem Kondratskyi, Philippe Lory, Edward Perez-Reyes
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e2976 (2008)
The intracellular loops that interlink the four transmembrane domains of Ca(2+)- and Na(+)-channels (Ca(v), Na(v)) have critical roles in numerous forms of channel regulation. In particular, the intracellular loop that joins repeats I and II (I-II lo
Externí odkaz:
https://doaj.org/article/a7c1bc0a7af04ff799dfaf61a90642da
Publikováno v:
Pflügers Archiv European Journal of Physiology
Pflügers Archiv European Journal of Physiology, Springer Verlag, 2020, ⟨10.1007/s00424-020-02429-7⟩
Pflugers Archiv
Pflügers Archiv European Journal of Physiology, Springer Verlag, 2020, ⟨10.1007/s00424-020-02429-7⟩
Pflugers Archiv
International audience; T-type, low-voltage activated, calcium channels, now designated Cav3 channels, are involved in a wide variety of physiological functions, especially in nervous systems. Their unique electrophysiological properties allow them t
Autor:
Hathaichanok Impheng, Christian Legros, Narawut Pakaprot, Philippe Lory, Malik Bouasse, Céline Lemmers, Arnaud Monteil, Nathalie C. Guérineau
Publikováno v:
FASEB Journal
FASEB Journal, 2021, 35 (5), pp.e21400. ⟨10.1096/fj.202000841rr⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2021, 35 (5), pp.e21400. ⟨10.1096/fj.202000841rr⟩
FASEB Journal, 2021, 35 (5), pp.e21400. ⟨10.1096/fj.202000841rr⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2021, 35 (5), pp.e21400. ⟨10.1096/fj.202000841rr⟩
International audience; Anterior pituitary endocrine cells that release hormones such as growth hormone and prolactin are excitable and fire action potentials. In these cells, several studies previously showed that extracellular sodium (Na+ ) removal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88e5c8cde1ae30763b0e9bccd6ec728
https://hal.science/hal-03188856
https://hal.science/hal-03188856