Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Philippe Laugâa"'
Insight into the mechanism of action of EP-39, a bevirimat derivative that inhibits HIV-1 maturation
Autor:
Aymeric Neyret, Bernard Gay, Anaïs Cransac, Laurence Briant, Pascale Coric, Serge Turcaud, Philippe Laugâa, Serge Bouaziz, Nathalie Chazal
Publikováno v:
Antiviral Research
Antiviral Research, Elsevier Masson, 2019, 164, pp.162-175. ⟨10.1016/j.antiviral.2019.02.014⟩
Antiviral Research, 2019, 164, pp.162-175. ⟨10.1016/j.antiviral.2019.02.014⟩
Antiviral Research, Elsevier Masson, 2019, 164, pp.162-175. ⟨10.1016/j.antiviral.2019.02.014⟩
Antiviral Research, 2019, 164, pp.162-175. ⟨10.1016/j.antiviral.2019.02.014⟩
International audience; Maturation of human immunodeficiency virus type 1 (HIV-1) particles is a key step for viral infectivity. This process can be blocked using maturation inhibitors (MIs) that affect the cleavage of the capsid-spacer peptide 1 (CA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc5ed1c5e94c5c23aebd0b7c278b620
https://hal.archives-ouvertes.fr/hal-02147099/file/1-s2.0-S0166354218307162-main(1).pdf
https://hal.archives-ouvertes.fr/hal-02147099/file/1-s2.0-S0166354218307162-main(1).pdf
Publikováno v:
Journal of Molecular Biology. 331:745-758
To investigate the codon dependence of human eRF1 binding to the mRNA-ribosome complex, we examined the formation of photocrosslinks between ribosomal components and mRNAs bearing a photoactivable 4-thiouridine probe in the first position of the codo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f4b1c974bd5a29e3ba6515359b6ea25
https://doi.org/10.1016/s0022-2836(03)00813-1
https://doi.org/10.1016/s0022-2836(03)00813-1
Autor:
Carole Saintomé, Jean-Louis Fourrey, Alain Favre, Pascale Clivio, Philippe Laugâa, A. Woisard
Publikováno v:
Tetrahedron. 56:1197-1206
The nucleosidic photolabels 2 – 5 , able to form long-range photo-cross-links, have been used to further investigate the tertiary folding of a hammerhead ribozyme domain. These photolabels derive from 2′-deoxyuridine which is substituted at its C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ba52fab9e114f2fa537feefbdc1bd9a
https://doi.org/10.1016/s0040-4020(00)00024-7
https://doi.org/10.1016/s0040-4020(00)00024-7
Publikováno v:
Biochimie. 81:201-212
The conformation in solution of a small bipartite I-III hammerhead ribozyme has been deduced from the photo-cross-links formed between cleavable ribo-deoxysubstrates appropriately substituted with the probe deoxy-4-thiouridine and ribozyme residues.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93784d8cd00bc4bc746878853824fe6c
https://doi.org/10.1016/s0300-9084(99)80053-4
https://doi.org/10.1016/s0300-9084(99)80053-4
Autor:
Catherine Fontaine, Jean-Louis Fourrey, Philippe Laugâa, Pascale Clivio, Alain Favre, Eric Guittet, Jeannette Gasche
Publikováno v:
Tetrahedron. 48:1605-1616
Preparation, spectroscopic analysis and molecular modelling of dYo(4-α;p)dTand dhs4U(6-α;p)dt, two photoproducts of 2′-deoxy-4-thioridylyl-(3′,5′)-thymidine are described. The 6(S) configuration of the additional chiral centre of dhs4U(6-α;p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16ae3f8e8114c4da96ead60a8a3cdd88
https://doi.org/10.1016/s0040-4020(01)88719-6
https://doi.org/10.1016/s0040-4020(01)88719-6
Publikováno v:
Journal of photochemistry and photobiology. B, Biology. 42(2)
In the past few years thionucleobases have been extensively used as intrinsic photolabels to probe the structure in solution of folded RNA molecules and to identify contacts within nucleic acids and/or between nucleic acids and proteins, in complex n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15cc8216726f0af83fee688d89f7f5e9
https://pubmed.ncbi.nlm.nih.gov/9540218
https://pubmed.ncbi.nlm.nih.gov/9540218
Folding of the HDV antigenomic ribozyme pseudoknot structure deduced from long-range photocrosslinks
A trans-acting system has been designed in order to explore the three-dimensional structure of the anti-genomic HDV ribozyme. In this system, the substrate (SANT) is associated by base-pairing to the catalytic RNA (RzANT) forming helix H1. RzANT is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67a463fefd9afc7dcae3887824b6f21
https://europepmc.org/articles/PMC145789/
https://europepmc.org/articles/PMC145789/
Publikováno v:
Chemical Communications. :167-168
The photo-crosslinking behaviour of oligonucleotide constructs, incorporating photoactive residues 1–5 at a defined position, has been examined in the presence of their DNA (14-mer) and RNA (15-mer) complementary targets using a two-fold excess; it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b4e4eeee8a94fe8e251673c984b209f
https://doi.org/10.1039/a606330f
https://doi.org/10.1039/a606330f