Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Philippe Lalle"'
Autor:
Anne-Sophie Wozny, Gersende Alphonse, Audrey Cassard, Céline Malésys, Safa Louati, Michael Beuve, Philippe Lalle, Dominique Ardail, Tetsuo Nakajima, Claire Rodriguez-Lafrasse
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Abstract DNA double-strand breaks (DSBs) induced by photon irradiation are the most deleterious damage for cancer cells and their efficient repair may contribute to radioresistance, particularly in hypoxic conditions. Carbon ions (C-ions) act indepen
Externí odkaz:
https://doaj.org/article/b9246a0bfb4742b4a947afac465121a4
Publikováno v:
Distances et Médiations des Savoirs, Vol 26 (2019)
This article has two objectives : to explain the engineering and pedagogical design of an online continuous training system for academics, beginners or not, to university pedagogy, and to evaluate its declared uses from a professional development per
Externí odkaz:
https://doaj.org/article/3124689fa0a345af810a487746d740f3
Autor:
Simone Bonnafous, Philippe Lalle
Publikováno v:
Revue internationale d'éducation de Sèvres. :49-60
Depuis un certain nombre d’annees, l’universite connait de nombreuses mutations qui font evoluer l’enseignement et favorisent le developpement d’un objet nouveau : la pedagogie universitaire. Les pratiques d’enseignement se modifient sous l
Publikováno v:
Distances et médiations des savoirs.
Cet article vise deux objectifs : expliciter les choix d’ingenierie et de conception pedagogique d’un dispositif de formation continue en ligne des enseignants-chercheurs, debutants ou experimentes, a la pedagogie universitaire, et en evaluer les
Autor:
Yannick Saintigny, Claire Rodriguez-Lafrasse, Nicolas Magné, Emilie Blond, Michael Beuve, Philippe Lalle, Jean-Baptiste Guy, Priscillia Battiston-Montagne, Alexandra Lauret, Gersende Alphonse, Micaela Cunha, Dominique Ardail, Anne-Sophie Wozny
Publikováno v:
British Journal of Cancer
British Journal of Cancer, Cancer Research UK, 2017, 116 (10), pp.1340-1349. ⟨10.1038/bjc.2017.100⟩
Breast Cancer Research and Treatment
Breast Cancer Research and Treatment, Springer Verlag, 2017, 116 (10), pp.1340-1349. ⟨10.1038/bjc.2017.100⟩
British Journal of Cancer, 2017, 116 (10), pp.1340-1349. ⟨10.1038/bjc.2017.100⟩
British Journal of Cancer, Cancer Research UK, 2017, 116 (10), pp.1340-1349. ⟨10.1038/bjc.2017.100⟩
Breast Cancer Research and Treatment
Breast Cancer Research and Treatment, Springer Verlag, 2017, 116 (10), pp.1340-1349. ⟨10.1038/bjc.2017.100⟩
British Journal of Cancer, 2017, 116 (10), pp.1340-1349. ⟨10.1038/bjc.2017.100⟩
International audience; Background: Head and neck squamous cell carcinoma (HNSCC) are resistant to standard treatments, partly due to cancer stem cells (CSCs) localised in hypoxic niches. Compared to X-rays, carbon ion irradiation relies on better ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c03cbfd7b5ef367f6892a61d2167408
https://hal-cea.archives-ouvertes.fr/cea-01938093
https://hal-cea.archives-ouvertes.fr/cea-01938093
Autor:
Yannis Guillemin, Germain Gillet, Philippe Lalle, Abdel Aouacheria, Samir Hamamah, Jean-François Guérin
Publikováno v:
Journal of Molecular Medicine. 87:923-940
Apoptosis has been reported in oocytes and human preimplantation embryos both in vitro and in vivo. BCL-2 family proteins are likely to play a pivotal role in controlling oocyte and early embryo degeneration. However, no BCL-2-related survival factor
Autor:
Philippe Lalle, Lohez Od, Germain Gillet, Pierre Colas, Thibaut J, Nouvion Al, Séverine Venet
Publikováno v:
Oncogene. 26:701-710
Tumor cells are characterized by deregulated proliferation and resistance to proapoptotic stimuli. The Bcl-2 family of antiapoptotic proteins is overexpressed in a large number of chemoresistant tumors. Downregulation or inhibition of antiapoptotic p
Autor:
Stuart G. Clarkson, Mahmud K.K. Shivji, Thierry Nouspikel, Angelos Constantinou, Wim Vermeulen, Philippe Lalle, Fabrizio Thorel, Richard D. Wood, Anja Raams, Nicolaas G. J. Jaspers, Isabelle Dunand-Sauthier
Publikováno v:
Molecular and Cellular Biology, 24(24), 10670-10680. American Society for Microbiology
XPG is the human endonuclease that cuts 3' to DNA lesions during nucleotide excision repair. Missense mutations in XPG can lead to xeroderma pigmentosum (XP), whereas truncated or unstable XPG proteins cause Cockayne syndrome (CS), normally yielding
Publikováno v:
Journal of Investigative Dermatology
Journal of Investigative Dermatology, Nature Publishing Group, 2002, 118, pp.344-351
Journal of Investigative Dermatology, Nature Publishing Group, 2002, 118, pp.344-351
International audience; Of the eight human genes implicated in xeroderma pigmentosum, defects in XPG produce some of the most clinically diverse symptoms. These range from mild freckling to severe skeletal and neurologic abnormalities characteristic
Autor:
Rosa B. Barkardottir, R.S. Cornelis, Åke Borg, Patricia N. Tonin, Siegfried Scherneck, Susan L. Neuhausen, Catharina Larsson, Michel Longy, Adalgeir Arason, Annika Lindblom, Philippe Lalle, Jenny Chang-Claude, O. Johansson, Bruce A.J. Ponder, Hagay Sobol, Edith Olah, Ute Hamann, Nigel K. Spurr, Peter Devilee, Yves-Jean Bignon, Steven A. Narod, David P. Kelsell
Publikováno v:
Genes, Chromosomes and Cancer. 13:203-210
Loss of heterozygosity (LOH) was evaluated in 174 breast and ovarian tumors derived from 94 families with at least 3 first-degree relatives affected with either of these cancers. By linkage analysis 26 families were identified as having a high poster