Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Philippe Lafitte"'
Autor:
Elizabeth Santana dos Santos, Amanda B. Spurdle, Dirce M. Carraro, Adrien Briaux, Melissa Southey, Giovana Torrezan, Ambre Petitalot, Raphael Leman, Philippe Lafitte, kConFab Investigators, Didier Meseure, Keltouma Driouch, Lucy Side, Carole Brewer, Sarah Beck, Athalie Melville, Alison Callaway, Françoise Revillion, Maria A. A. Koike Folgueira, Michael T. Parsons, Heather Thorne, Anne Vincent-Salomon, Dominique Stoppa-Lyonnet, Ivan Bieche, Sandrine M. Caputo, Etienne Rouleau
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract At least 10% of the BRCA1/2 tests identify variants of uncertain significance (VUS) while the distinction between pathogenic variants (PV) and benign variants (BV) remains particularly challenging. As a typical tumor suppressor gene, the ina
Externí odkaz:
https://doaj.org/article/11725e206c6145aaaf00ff5e47624a06
Autor:
Sandrine M. Caputo, Sophie Zinn-Justin, Bernard S. Lopez, Rosette Lidereau, Etienne Rouleau, Catherine Noguès, Jean-Christophe Aude, Philippe Lafitte, Jeff A. Schnell, Jean Feunteun, Dorine Bonte, Isslam Bouazzaoui, Patrick Julien, Josée Guirouilh-Barbat, Naima Nhiri, Eric Jacquet, Elodie Dardillac, Ambre Petitalot
Isothermal Titration Calorimetry curves obtained by adding the different phosphopeptides at (A-B) 200 mM onto the WT BRCT domains at 20 mM and (C-D) 100 mM onto the WT BRCT domains at 10 mM .
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22dec69eab22ab3b11280be35673d603
https://doi.org/10.1158/1541-7786.22516320.v1
https://doi.org/10.1158/1541-7786.22516320.v1
Autor:
Sandrine M. Caputo, Sophie Zinn-Justin, Bernard S. Lopez, Rosette Lidereau, Etienne Rouleau, Catherine Noguès, Jean-Christophe Aude, Philippe Lafitte, Jeff A. Schnell, Jean Feunteun, Dorine Bonte, Isslam Bouazzaoui, Patrick Julien, Josée Guirouilh-Barbat, Naima Nhiri, Eric Jacquet, Elodie Dardillac, Ambre Petitalot
BRCA1 mutations have been identified that increase the risk of developing hereditary breast and ovarian cancers. Genetic screening is now offered to patients with a family history of cancer, to adapt their treatment and the management of their relati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b45b9eb3f37bba3880f02c4ad9363ac2
https://doi.org/10.1158/1541-7786.c.6541344
https://doi.org/10.1158/1541-7786.c.6541344
Autor:
Sandrine M. Caputo, Sophie Zinn-Justin, Bernard S. Lopez, Rosette Lidereau, Etienne Rouleau, Catherine Noguès, Jean-Christophe Aude, Philippe Lafitte, Jeff A. Schnell, Jean Feunteun, Dorine Bonte, Isslam Bouazzaoui, Patrick Julien, Josée Guirouilh-Barbat, Naima Nhiri, Eric Jacquet, Elodie Dardillac, Ambre Petitalot
The black bar corresponds to WT BRCA1, the blue bars to VUS of classes 1 and 2, the grey bars to VUS of class 3 and the red bars to VUS of classes 4 and 5. Bars boxed in green correspond to mutants that are defective in phosphopeptide-binding, as obs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09cebf5b95634847f2937299504bfb5b
https://doi.org/10.1158/1541-7786.22516326.v1
https://doi.org/10.1158/1541-7786.22516326.v1
Autor:
Sandrine M. Caputo, Sophie Zinn-Justin, Bernard S. Lopez, Rosette Lidereau, Etienne Rouleau, Catherine Noguès, Jean-Christophe Aude, Philippe Lafitte, Jeff A. Schnell, Jean Feunteun, Dorine Bonte, Isslam Bouazzaoui, Patrick Julien, Josée Guirouilh-Barbat, Naima Nhiri, Eric Jacquet, Elodie Dardillac, Ambre Petitalot
FBTSA assay revealing that binding of the WT BRCA1 BRCT domains to ACC1-P, BACH1-P, CtiP-P, AB-1P and AB-2P induce a measurable increase in the BRCT thermostability that raises with peptide concentration.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a03158dbebb5c31bc66fd342597e32
https://doi.org/10.1158/1541-7786.22516314
https://doi.org/10.1158/1541-7786.22516314
Autor:
Sandrine M. Caputo, Sophie Zinn-Justin, Bernard S. Lopez, Rosette Lidereau, Etienne Rouleau, Catherine Noguès, Jean-Christophe Aude, Philippe Lafitte, Jeff A. Schnell, Jean Feunteun, Dorine Bonte, Isslam Bouazzaoui, Patrick Julien, Josée Guirouilh-Barbat, Naima Nhiri, Eric Jacquet, Elodie Dardillac, Ambre Petitalot
Mutated BRCT domains fused to GST were expressed in E. coli and purified by affinity chromatography using glutathione beads. This figure shows a SDS-PAGE gel with samples from the bacterial pellet (P), supernatant (S) and the glutathione beads (G) af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::927bafcd0af3c9d874bd9e4737f7cad7
https://doi.org/10.1158/1541-7786.22516332
https://doi.org/10.1158/1541-7786.22516332
Autor:
Sandrine M. Caputo, Sophie Zinn-Justin, Bernard S. Lopez, Rosette Lidereau, Etienne Rouleau, Catherine Noguès, Jean-Christophe Aude, Philippe Lafitte, Jeff A. Schnell, Jean Feunteun, Dorine Bonte, Isslam Bouazzaoui, Patrick Julien, Josée Guirouilh-Barbat, Naima Nhiri, Eric Jacquet, Elodie Dardillac, Ambre Petitalot
Size Exclusion Chromatography profiles obtained on BRCA1 BRCT domains free (red curve) or in complex with BACH1-P (purple), AB-1P (green), AB-2P (blue). The experiment was performed using a Superdex-75 10/300 GL column (GE Healthcare) pre-equilibrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::942b70e5108f3e81c42b65b49d78883d
https://doi.org/10.1158/1541-7786.22516317.v1
https://doi.org/10.1158/1541-7786.22516317.v1
Autor:
Sandrine M. Caputo, Sophie Zinn-Justin, Bernard S. Lopez, Rosette Lidereau, Etienne Rouleau, Catherine Noguès, Jean-Christophe Aude, Philippe Lafitte, Jeff A. Schnell, Jean Feunteun, Dorine Bonte, Isslam Bouazzaoui, Patrick Julien, Josée Guirouilh-Barbat, Naima Nhiri, Eric Jacquet, Elodie Dardillac, Ambre Petitalot
FBTSA assays performed to measure binding of the mutated BRCA1 BRCT domains to ACC1-P, BACH1-P, CtiP-P, AB-1P and AB-2P.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bcb0ea74fec9143ceb078c686be4488
https://doi.org/10.1158/1541-7786.22516311.v1
https://doi.org/10.1158/1541-7786.22516311.v1
Autor:
Ambre, Petitalot, Elodie, Dardillac, Eric, Jacquet, Naima, Nhiri, Josée, Guirouilh-Barbat, Patrick, Julien, Isslam, Bouazzaoui, Dorine, Bonte, Jean, Feunteun, Jeff A, Schnell, Philippe, Lafitte, Jean-Christophe, Aude, Catherine, Noguès, Etienne, Rouleau, Rosette, Lidereau, Bernard S, Lopez, Sophie, Zinn-Justin, Sandrine M, Caputo
Publikováno v:
Molecular cancer research : MCR. 17(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dbc7a7bf9ba6794c009e850ec9b64728
https://pubmed.ncbi.nlm.nih.gov/30257991
https://pubmed.ncbi.nlm.nih.gov/30257991
Autor:
Sahra, Bodo, Magali, Svrcek, Isabelle, Sourrouille, Peggy, Cuillières-Dartigues, Tatiana, Ledent, Sylvie, Dumont, Laetitia, Dinard, Philippe, Lafitte, Camille, Capel, Ada, Collura, Olivier, Buhard, Kristell, Wanherdrick, Alexandra, Chalastanis, Virginie, Penard-Lacronique, Bettina, Fabiani, Jean-François, Fléjou, Nicole, Brousse, Laurent, Beaugerie, Alex, Duval, Martine, Muleris
Publikováno v:
Oncotarget
Mismatch-repair (MMR)-deficient cells show increased in vitro tolerance to thiopurines because they escape apoptosis resulting from MMR-dependent signaling of drug-induced DNA damage. Prolonged treatment with immunosuppressants including azathioprine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5e654aeac6cb891d53ea1e0aafb5434e
https://pubmed.ncbi.nlm.nih.gov/26327213
https://pubmed.ncbi.nlm.nih.gov/26327213