Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Philippe Kennel"'
Autor:
D. de Barbeyrac, Ian Kimber, Philippe Kennel, David Rouquié, B. U. Stahl, H. Aldemir, Remi Bars, Rebecca J. Dearman, Corinne Herouet-Guicheney
Publikováno v:
Journal of Applied Toxicology. 29:141-148
Assessment of the potential allergenicity of novel proteins, including those expressed in genetically modified plants, is an important issue. In previous studies, we have shown that the IgE measurement induced by systemic exposure of BALB/c mice to a
Autor:
Corinne Cayatte, David Rouquié, Remi Bars, Catherine Pons, Bernard Rossi, Laetitia Elies, Jean-Marie Guigonis, Philippe Kennel, Jérôme Pizzol, Michel Samson
Publikováno v:
Molecular & Cellular Proteomics. 5:2031-2043
To better understand the effects of antiandrogens on the prostate, we investigated the changes in the proteome of rat ventral prostate (VP) following treatment with a well characterized 5alpha-reductase inhibitor, finasteride. Sprague-Dawley rats wer
Autor:
Delaere P, Jacques Mallet, Finiels F, Naimi-Sadaoui S, Frederic Revah, Philippe Kennel, Orsini C, Daniel Scherman, Pierre-François Pradat
Publikováno v:
Gene Therapy. 9:1333-1337
Sensory neuropathies are a frequent and dose-limiting complication resulting from treatment with cisplatin. Neurotrophin-3 (NT-3) promotes the survival of the large fiber sensory neurones that are impaired in cisplatin-induced neuropathy, and may the
Autor:
Françoise Finiels, Pierre-François Pradat, Philippe Kennel, Pia Delaere, Frederic Revah, Cecile Orsini, Souad Naimi-Sadaoui, Jacques Mallet
Publikováno v:
Human Gene Therapy. 12:2237-2249
Neurotrophic factors (NFs) are promising agents for the treatment of peripheral neuropathies such as diabetic neuropathy. However, the value of treatment with recombinant NF is limited by the short half-lives of these molecules, which reduces efficie
Autor:
Philippe Kennel, Souad Naimi, Pierre-François Pradat, Frederic Revah, Jacques Mallet, Cecile Orsini, Françoise Finiels, Pia Delaere
Publikováno v:
Human Gene Therapy. 12:367-375
Cisplatin-induced sensory peripheral neuropathy is the dose-limiting factor for cisplatin chemotherapy. We describe the preventive effect of NT-3 delivery, using direct gene transfer into muscle by in vivo electroporation in a mouse model of cisplati
Autor:
Claire Friry-Santini, David Rouquié, Remi Bars, Philippe Kennel, Mohamed Benahmed, Helen Tinwell
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 97(1)
In conventional rodent toxicity studies the characterization of the adverse effects of a chemical relies primarily on gravimetric, and histopathological data. The aim of this study was to evaluate if the use of two-dimensional gel electrophoresis cou
Publikováno v:
Reproductive toxicology (Elmsford, N.Y.). 18(1)
Three chemicals with known endocrine activities have been evaluated in the rat Hershberger assay for phase-2 of the international validation exercise within the Organization for Economic Cooperation and Development (OECD). The chemicals studied inclu
Publikováno v:
Archives of toxicology. 77(9)
The main objective of this 28-day oral gavage toxicity study in the rat was to investigate which of the current and/or additional parameters of the OECD Test Guideline 407 would reliably and sensitively detect the endocrine-mediated effects of the no
Autor:
Philippe Kennel, Isabelle Loquet, Abderrahim Mahfoudi, Vincent Thuillier, Martine Latta-Mahieu, Manping Wang, Emanuelle Trannoy, Irene Mahfouz, Magali Rolland, Jean-Franç Ois Dedieu, Catherine Caillet
Publikováno v:
Human gene therapy. 13(13)
Pharmacologic gene regulation is a key technology, necessary to achieve safe, long-term gene transfer. The approaches described in the scientific literature all share in common the creation of artificial transcription factors by fusing a DNA-binding
Autor:
Philippe Kennel, Adam Doble
Publikováno v:
Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases. 1(5)
Animal models of human disease are important in unravelling the pathophysiology of the condition, for exploring the natural history of disease and for evaluating potential therapies. The development of animal models of human neurodegenerative disease