Výsledky vyhledávání - "Philippe Gripon"

Interleukin 6 inhibits HBV entry through NTCP down regulation

Autor: Olivier Fardel, Philippe Gripon, Fidaa Bouezzedine

Publikováno v: Virology
Virology, Elsevier, 2015, 481, pp.34-42. ⟨10.1016/j.virol.2015.02.026⟩
Virology, 2015, 481, pp.34-42. ⟨10.1016/j.virol.2015.02.026⟩

International audience; Hepatitis B virus (HBV) infection is a major public health problem. Recently, the human liver bile acid transporter Na+/taurocholate cotransporting polypeptide (NTCP) has been identified as an HBV specific receptor. NTCP expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d904af9e4f78f2d0be3553665058025

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Entry of pseudotyped hepatitis C virus into primary human hepatocytes depends on the scavenger class B type I receptor

Autor: Philippe Gripon, J. Le Seyec, Morgane Régeard, Cécile Lepère, Maud Trotard

Publikováno v: Journal of Viral Hepatitis. 15:865-870

Entry of the hepatitis C virus (HCV) into the cell seems to be a complex multi-step process involving several cellular factors such as the scavenger class B type I receptor (SRBI). Until now, all investigations conducted to assess the involvement of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48c1a4f2d5f34ffbfcd07124470738d5
https://doi.org/10.1111/j.1365-2893.2008.01048.x

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A concerted action of HNF4α and HNF1α links hepatitis B virus replication to hepatocyte differentiation

Autor: Ulrike Protzer, Uta Drebber, Maria Quasdorff, Dirk L. Stippel, Tobias Goeser, Margarete Odenthal, Felix Bohne, Philippe Gripon, Uta Zedler, Hans-Peter Dienes, Marianna Hösel

Publikováno v: Cellular Microbiology
Cellular Microbiology, Wiley, 2008, 10 (7), pp.1478-90. ⟨10.1111/j.1462-5822.2008.01141.x⟩
Cellular Microbiology, 2008, 10 (7), pp.1478-90. ⟨10.1111/j.1462-5822.2008.01141.x⟩

International audience; Hepatitis B virus (HBV) is an important human pathogen, which targets the liver extremely efficient, gaining access to hepatocytes by a so far unknown receptor and replicating in a hepatocyte-specific fashion. Cell differentia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::942f2c812aa30027325ebeede5164f7c
https://doi.org/10.1111/j.1462-5822.2008.01141.x

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Recent contributions of in vitro models to our understanding of hepatitis C virus life cycle

Autor: Morgane Régeard, Charlotte Lepère, Jacques Le Seyec, Philippe Gripon, Maud Trotard

Publikováno v: FEBS Journal. 274:4705-4718

Hepatitis C virus is a human pathogen responsible for liver diseases including acute and chronic hepatitis, cirrhosis and hepatocellular carcinoma. Its high prevalence, the absence of a prophylactic vaccine and the poor efficiency of current therapie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e38a2a597851270984eaa9a8fd2f8d20
https://doi.org/10.1111/j.1742-4658.2007.06017.x

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Enhanced humanization and affinity maturation of neutralizing anti-hepatitis B virus preS1 antibody based on antigen–antibody complex structure

Autor: Jin Hong Kim, Philippe Gripon, Mun Sik Jeong, Seung Wook Chi, Seong Eon Ryu, Fidaa Bouezzedine, Hyo Jeong Hong

Publikováno v: FEBS Letters
FEBS Letters, Wiley, 2015, 589 (2), pp.193-200. ⟨10.1016/j.febslet.2014.11.046⟩
FEBS Letters, 2015, 589 (2), pp.193-200. ⟨10.1016/j.febslet.2014.11.046⟩

International audience; To improve a previously constructed broadly neutralizing hepatitis B virus (HBV)-specific preS1 humanized antibody (HzKR127), we further humanized it through specificitydetermining residue (SDR) grafting. Moreover, we improved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b9cfe8ff85adb5a6bec227ab495e30
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01110668/document

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Hepatocyte iron loading capacity is associated with differentiation and repression of motility in the HepaRG cell line

Autor: Karim Boudjema, Martine Le Cunff, Pierre Brissot, Lénaïck Détivaud, Isabelle Guisle, Hélène Duval, Philippe Gripon, Emilie Guérin, Jean J. Leger, Olivier Loréal, Denise Glaise, Patricia Leroyer, Nathalie Théret, Marie-Bérengère Troadec, Christiane Guguen-Guillouzo, Nolwenn Le Meur, Pierre Zindy, Guillaume Lamirault

Publikováno v: Genomics
Genomics, Elsevier, 2006, 87 (1), pp.93-103. ⟨10.1016/j.ygeno.2005.08.016⟩
Genomics, 2006, 87 (1), pp.93-103. ⟨10.1016/j.ygeno.2005.08.016⟩

International audience; High liver iron content is a risk factor for developing hepatocellular carcinoma (HCC). However, HCC cells are always iron-poor. Therefore, an association between hepatocyte iron storage capacity and differentiation is suggest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16b5973c0086d48627dda63f052d76c
https://doi.org/10.1016/j.ygeno.2005.08.016

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Infection of a human hepatoma cell line by hepatitis B virus

Autor: Josette Lucas, Christiane Guguen-Guillouzo, Stephan Urban, Jacques Le Seyec, Isabelle Cannie, Christian Trepo, Sylvie Rumin, Philippe Gripon, Denise Glaise, Claire Guyomard

Publikováno v: Proceedings of the National Academy of Sciences. 99:15655-15660

Among numerous established human hepatoma cell lines, none has been shown susceptible to hepatitis B virus (HBV) infection. We describe here a cell line, called HepaRG, which exhibits hepatocyte-like morphology, expresses specific hepatocyte function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e90ff3bef41a1c91edc4f228a26bdc
https://doi.org/10.1073/pnas.232137699

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