Výsledky vyhledávání - "Philippe Giummelly"

S-Nitrosothiols as potential therapeutics to induce a mobilizable vascular store of nitric oxide to counteract endothelial dysfunction

Autor: Philippe Giummelly, Caroline Gaucher, Marianne Parent, Valérie Salgues, Isabelle Lartaud, Yi Zhou, Caroline Perrin-Sarrado

Publikováno v: Biochemical Pharmacology
Biochemical Pharmacology, Elsevier, 2020, 173, pp.113686. ⟨10.1016/j.bcp.2019.113686⟩

Endothelial dysfunction predisposing to cardiovascular diseases is defined as an imbalance in the production of vasodilating factors, such as nitric oxide (NO), and vasoconstrictive factors. To insure its physiological role, NO, a radical with very s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb69f51dd5cfc2535190d7acf7c9ff2
https://hal.archives-ouvertes.fr/hal-02493406

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Flush with a flash: natural three-component antimicrobial combinations based on S-nitrosothiols, controlled superoxide formation and 'domino' reactions leading to peroxynitrite

Autor: Chukwunonso E.C.C. Ejike, Pierre Leroy, Justine Bonetti, Ahmad Yaman Abdin, Rama Alhasan, Ammar Kharma, Muhammad Jawad Nasim, Claus Jacob, Philippe Giummelly, Caroline Gaucher

Publikováno v: MedChemComm
MedChemComm, Royal Society of Chemistry, 2018, 9 (12), pp.1994-1999. ⟨10.1039/C8MD00414E⟩

S-Nitrosothiols are ˙NO releasing agents renowned for vasodilatory and antioxidant properties. O(2)˙(–) promotes their decomposition, forming highly aggressive peroxynitrite ions (ONOO(–)). Since the production of O(2)˙(–) can be controlled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d911d97cb23870531fbbc2a4359af67a
https://hal.archives-ouvertes.fr/hal-02044926

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In vivo and in silico evaluation of a new nitric oxide donor, S,S′ -dinitrosobucillamine

Autor: François Dupuis, Caroline Perrin-Sarrado, Alessandro Genoni, Pierre Leroy, Philippe Giummelly, Ariane Boudier, Valérie Salgues, Benjamin Meyer, Isabelle Lartaud, Igor Clarot, Manuel F. Ruiz-López, Patrick Limiñana, Mostafa Kouach, Marie-Lynda Bouressam

Publikováno v: Nitric Oxide: Biology and Chemistry
Nitric Oxide: Biology and Chemistry, Elsevier, 2017, 71, pp.32-43. ⟨10.1016/j.niox.2017.10.004⟩
Nitric Oxide: Biology and Chemistry, 2017, 71, pp.32-43. ⟨10.1016/j.niox.2017.10.004⟩

International audience; Purpose: In a previous work, we have synthetized a new dinitrosothiol, i.e. S,S′-dinitrosobucillamine BUC(NO)2 combining S-nitroso-N-acetylpenicillamine (SNAP) and S-nitroso-N-acetylcysteine (NACNO) in its structure. When ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e486b3faf94c09ab2f12953ca08e7c
https://hal.univ-lorraine.fr/hal-01665352/file/Bouressam_et_al_Nitric_Oxide_2017.pdf

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Effects of dexamethasone andl-canavanine on the intracellular calcium-contraction relation of the rat tail artery during septic shock

Autor: Jeffrey Atkinson, Pierre-Edouard Bollaert, Arnaud Mansart, Philippe Giummelly, Christine Capdeville-Atkinson

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 291:H1177-H1182

The intracellular mechanism by which sepsis lowers vascular reactivity and the subsequent reversal by dexamethasone or nitric oxide synthase (NOS) inhibitors remain unclear. We measured the sensitivity of contraction of the rat tail artery to intrace

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0677ab57619e75ba7234d2046285b7d
https://doi.org/10.1152/ajpheart.00997.2005

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Decreased aortic smooth muscle contraction in a rat model of multibacterial sepsis

Autor: Philippe Giummelly, Arnaud Mansard, Jeffrey Atkinson, Changhua Wang

Publikováno v: Fundamental and Clinical Pharmacology. 18:679-683

We investigated whether blockade of the smooth muscle cell (SMC) inducible nitric oxide synthase (iNOS)-soluble guanylyl cyclase (sGC) vasodilator pathway would restore the fall in vasoreactivity produced by sepsis following cecal ligation and perfor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93584db93574bd579b4492a8ceea1cd2
https://doi.org/10.1111/j.1472-8206.2004.00293.x

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Melatonin potentiates NE-induced vasoconstriction without augmenting cytosolic calcium concentration

Autor: Christine Capdeville-Atkinson, C. Vandeputte, Jeffrey Atkinson, Philippe Giummelly, Elizabeth Scalbert, Philippe Delagrange

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 280:H420-H425

Because little is known of the intracellular mechanisms involved in the vasoconstrictor effect of melatonin (Mel), we examined the in vitro effects of Mel by using perfused cylindrical segments of the rat tail artery loaded with the intracellular Ca2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47b00741212d03a38db0c1f2efdec06
https://doi.org/10.1152/ajpheart.2001.280.1.h420

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Nitric oxide lowers the calcium sensitivity of tension in the rat tail artery

Autor: Philippe Giummelly, Esther Spitzbarth, Jeffrey Atkinson, Nguyen Tran, A. Robert, Christine Capdeville-Atkinson

Publikováno v: The Journal of Physiology. 507:163-174

1. Controversy exists as to whether a fall in the intracellular Ca2+ concentration ([Ca2+]i) is a requisite element of the vasodilatory response to nitric oxide (NO). 2. We studied the effect of NO on the coupling between [Ca2+]i and vasoconstriction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e825d9552dbff22e0fa0689a2db3fb1b
https://doi.org/10.1111/j.1469-7793.1998.163bu.x

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Calcification of Medial Elastic Fibers and Aortic Elasticity

Autor: Philippe Giummelly, Isabelle Lartaud-Idjouadiene, C. Duvivier, Jeffrey Atkinson, N. Niederhoffer, R. Peslin

Publikováno v: Scopus-Elsevier

Abstract We tested the hypothesis that a simple change in wall composition (medial calcium overload of elastic fibers) can decrease aortic elasticity. Calcium overload was produced by hypervitaminosis D plus nicotine (VDN) in the young rat. Two month

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e920c60d6b4dbced77cb23ad14e37140
https://doi.org/10.1161/01.hyp.29.4.999

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Aortic Calcification Produced by Vitamin D3 plus Nicotine

Autor: Philippe Giummelly, N. Niederhoffer, Yuri V. Bobryshev, Isabelle Lartaud-Idjouadiene, Jeffrey Atkinson

Publikováno v: Journal of Vascular Research. 34:386-398

Calcification of the elastic arteries of the young rat by treatment with vitamin D and nicotine (VDN) has been proposed as an animal model of arterial calcification associated with age and age-related

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b6bf264c5f5e49f117b47cd79b2793db
https://doi.org/10.1159/000159247

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Antigenicity of Cell Wall Mannans of Candida albicans NIH A-207 Strain Cells Cultured in Galactose-Added Yeast Nitrogen Base Medium

Autor: Philippe Giummelly, Yoshio Okawa, Kouji Goto, Masayoshi Miyauchi

Publikováno v: Biological and Pharmaceutical Bulletin. 28:391-393

The cultivations of the Candida albicans NIH A-207 strain (A-strain) for 5 d at 27 and 37 degrees C in 500 mM galactose-added yeast nitrogen base medium (YNB-Gal) decreased the growth of blastoconidia and the pH in the cultures, with dry weights of 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b948fcb808d6b43848e6ff4faf74fcc
https://doi.org/10.1248/bpb.28.391

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