Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Philippe Galéra"'
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Context: Osteoarthritis (OA) is an invalidating articular disease characterized by cartilage degradation and inflammatory events. In horses, OA is associated with up to 60% of lameness and leads to reduced animal welfare along with extensive economic
Externí odkaz:
https://doaj.org/article/5df0bcc2f5ea4777b78e896dabc62652
Autor:
Marion Rouge, Florence Legendre, Razan Elkhatib, Christelle Delalande, Juliette Cognié, Fabrice Reigner, Philippe Barrière, Stefan Deleuze, Vincent Hanoux, Philippe Galéra, Hélène Bouraïma-Lelong
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 16778 (2023)
The castration of stallions is traditionally performed after puberty, at around the age of 2 years old. No studies have focused on the effects of early castration on osteoarticular metabolism. Thus, we aimed to compare early castration (3 days after
Externí odkaz:
https://doaj.org/article/864162d6a09e4d89bfbbdc5846eff3d2
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
Osteoarthritis (OA) is a degenerative disease that eventually leads to the complete degradation of articular cartilage. Articular cartilage has limited intrinsic capacity for self-repair and, to date, there is no curative treatment for OA. Humans and
Externí odkaz:
https://doaj.org/article/7f54de2a66ce48cbb91af05f87cd276b
Autor:
Manon Jammes, Frédéric Cassé, Emilie Velot, Arnaud Bianchi, Fabrice Audigié, Romain Contentin, Philippe Galéra
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 14169 (2023)
Osteoarthritis (OA) is a widespread osteoarticular pathology characterized by progressive hyaline cartilage degradation, exposing horses to impaired well-being, premature career termination, alongside substantial financial losses for horse owners. Am
Externí odkaz:
https://doaj.org/article/bf6cdc7c5d4243a797334e13dc93ff76
Autor:
Aurélie Cullier, Frédéric Cassé, Seng Manivong, Romain Contentin, Florence Legendre, Aracéli Garcia Ac, Pierre Sirois, Gaëlle Roullin, Xavier Banquy, Florina Moldovan, Lélia Bertoni, Fabrice Audigié, Philippe Galéra, Magali Demoor
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 8949 (2022)
Osteoarthritis (OA) is a degenerative and heterogeneous disease that affects all types of joint structures. Current clinical treatments are only symptomatic and do not manage the degenerative process in animals or humans. One of the new orthobiologic
Externí odkaz:
https://doaj.org/article/9fd7288185954154a236df3741beb2fb
Autor:
Romain Contentin, Manon Jammes, Bastien Bourdon, Frédéric Cassé, Arnaud Bianchi, Fabrice Audigié, Thomas Branly, Émilie Velot, Philippe Galéra
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5795 (2022)
Equine osteoarthritis (OA) leads to cartilage degradation with impaired animal well-being, premature cessation of sport activity, and financial losses. Mesenchymal stem cell (MSC)-based therapies are promising for cartilage repair, but face limitatio
Externí odkaz:
https://doaj.org/article/c744dcf3a4d245de80d05387ef954119
Autor:
Lélia Bertoni, Sandrine Jacquet-Guibon, Thomas Branly, Florence Legendre, Mélanie Desancé, Céline Mespoulhes, Martine Melin, Daniel-Jean Hartmann, Amandine Schmutz, Jean-Marie Denoix, Philippe Galéra, Magali Demoor, Fabrice Audigié
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0235251 (2020)
Osteoarthritis is a common cause of pain and economic loss in both humans and horses. The horse is recognized as a suitable model for human osteoarthritis, because the thickness, structure, and mechanical properties of equine articular cartilage are
Externí odkaz:
https://doaj.org/article/9a0fae6b5f0e413fbd5e830eeb39d342
Autor:
Clément Veys, Abderrahim Benmoussa, Romain Contentin, Amandine Duchemin, Emilie Brotin, Jérôme E. Lafont, Yannick Saintigny, Laurent Poulain, Christophe Denoyelle, Magali Demoor, Florence Legendre, Philippe Galéra
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5590 (2021)
Chondrosarcomas are malignant bone tumors. Their abundant cartilage-like extracellular matrix and their hypoxic microenvironment contribute to their resistance to chemotherapy and radiotherapy, and no effective therapy is currently available. MicroRN
Externí odkaz:
https://doaj.org/article/9f7d94c21c0b41ffb3a48a2358f8d712
Autor:
Bastien Bourdon, Frédéric Cassé, Nicolas Gruchy, Pierre Cambier, Sylvain Leclercq, Sarah Oddoux, Antoine Noël, Jérôme E. Lafont, Romain Contentin, Philippe Galéra
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3693 (2021)
Cartilage is a non-innervated and non-vascularized tissue. It is composed of one main cell type, the chondrocyte, which governs homeostasis within the cartilage tissue, but has low metabolic activity. Articular cartilage undergoes substantial stresse
Externí odkaz:
https://doaj.org/article/a0fea7495e9741ada30666447d983be1
Autor:
Florence Legendre, David Ollitrault, Tangni Gomez-Leduc, Mouloud Bouyoucef, Magalie Hervieu, Nicolas Gruchy, Frédéric Mallein-Gerin, Sylvain Leclercq, Magali Demoor, Philippe Galéra
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Abstract Mesenchymal stem cells (MSCs) hold promise for cartilage engineering. Here, we aimed to determine the best culture conditions to induce chondrogenesis of MSCs isolated from bone marrow (BM) of aged osteoarthritis (OA) patients. We showed tha
Externí odkaz:
https://doaj.org/article/82d6b1bbe1f74d39bee2a4236a55d4f9