Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Philippe G. Nantermet"'
Autor:
T. G. Murali Dhar, Antonella Converso, Pamela Haile, Kevin Peese, J. Robert Merritt, Anna Hurtley, Philippe G. Nantermet, Erika Araujo, Peter S. Dragovich, Anthony J. Roecker, Marie-Gabrielle Braun
Publikováno v:
Medicinal Chemistry Reviews ISBN: 9780996293280
Medicinal Chemistry Reviews
Medicinal Chemistry Reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66e16bc9d1579c74eee914139abbb67b
https://doi.org/10.29200/acsmedchemrev-v54.ch22
https://doi.org/10.29200/acsmedchemrev-v54.ch22
Autor:
David Spiegel, Paul Mann, Viswanathan Muthusamy, Philippe G. Nantermet, Egor Chirkin, Terry Roemer
Publikováno v:
Angewandte Chemie International Edition. 56:13036-13040
Systemic fungal infections represent an important public health concern, and new antifungal agents are highly desirable. Herein, we describe the design, synthesis, and biological evaluation of a novel class of antifungal compounds called antibody-rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07aaa6d6ebeb6b8a1acfc6de3804e328
https://doi.org/10.1002/anie.201707536
https://doi.org/10.1002/anie.201707536
Autor:
Dave Kohler, Ashley Nomland, Rada Vanessa L, Ray T. McClain, Philippe G. Nantermet, Matt Przybyciel, Christopher J. Welch, Rolf Schlake
Publikováno v:
ACS Sustainable Chemistry & Engineering. 4:4905-4912
Proof of principle is demonstrated for a novel approach for using pressurized liquid carbon dioxide (CO2) as a mobile phase for flash chromatography purification, rather than traditionally used organic solvents. Regulation of a pressurized CO2 supply
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33ba1143feaded2416ec2ad96f5d0d5c
https://doi.org/10.1021/acssuschemeng.6b01219
https://doi.org/10.1021/acssuschemeng.6b01219
Autor:
Kevin P. Bateman, Spencer D. Dreher, Yong Liu, Ian W. Davies, Zhi-Cai Shi, Tim Cernak, Christopher J. Welch, Erik L. Regalado, Tony Pereira, Roy Helmy, Jonathan Schneeweis, Louis-Charles Campeau, Simon Berritt, Alexander Buitrago Santanilla, Petr Vachal, Michael Shevlin, Philippe G. Nantermet
Publikováno v:
Science. 347:49-53
Breaking through the milligram floor When chemists synthesize compounds, the threshold for success is at least a milligram of product. This has been true for decades—even though biochemical assays have long since descended into microgram territory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2fc5f0c9b37a015f4ea6f9a68db07fd
https://doi.org/10.1126/science.1259203
https://doi.org/10.1126/science.1259203
Autor:
Ian W. Davies, Spencer D. Dreher, Ana Bellomo, Sophia M. Manolikakes, Keith P. Moore, Ray T. McClain, Cheol K. Chung, Peter S. Kutchukian, Petr Vachal, Philippe G. Nantermet, Thomas J. Greshock, Mario Ellwart, Zhengwei Peng, Paul Knochel
Publikováno v:
Angewandte Chemie (International ed. in English). 55(44)
The reactivity of a representative set of 17 organozinc pivalates with 18 polyfunctional druglike electrophiles (informers) in Negishi cross-coupling reactions was evaluated by high-throughput experimentation protocols. The high-fidelity scaleup of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f46dda6b7a8a8e4f11d35aff39e0c7
https://pubmed.ncbi.nlm.nih.gov/27690172
https://pubmed.ncbi.nlm.nih.gov/27690172
Autor:
Li Hao, Carolyn Bahnck-Teets, Catherine M. Wiscount, Daniel J. McKay, Carmela Molinaro, Ronald K. Chang, S S Carroll, Sivalenka Vijayasaradhi, Philippe G. Nantermet, Sanjay Kumar Singh, Christopher J. Bungard, Dubost David C, David Jonathan Bennett, Thomas J. Greshock, Hua-Poo Su, Rosa I. Sanchez, Vouy Linh Truong, Xu Min, John F. Fay, Jeanine E. Ballard, John A. McCauley, Christian Beaulieu, M. Katharine Holloway, Joseph P. Vacca, Michael W. Miller, Tummanapalli Satyanarayana, Sheldon Crane, William D. Shipe, Jesse J. Manikowski, Peter D. Williams, Christian Nadeau, Jennifer J. Gesell, Tracy L. Diamond, Peter J. Felock, Oscar Miguel Moradei
A novel HIV protease inhibitor was designed using a morpholine core as the aspartate binding group. Analysis of the crystal structure of the initial lead bound to HIV protease enabled optimization of enzyme potency and antiviral activity. This afford
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f685aed82b9b428b5b9e7330d8f427
https://europepmc.org/articles/PMC4948015/
https://europepmc.org/articles/PMC4948015/
Autor:
Geeta Kandpal, Ian J. Reynolds, Eleftheria N. Finger, John M. Sanders, J. Fred Hess, Keith P. Moore, Sophie Parmentier-Batteur, Hong Zhu, Robert J. Mark, Raghu Krishnan, Hemaka A. Rajapakse, Philippe G. Nantermet, Joseph P. Vacca, Theresa M. Williams, Christopher P. Regan, Sujata Sharma
Publikováno v:
Journal of Neurochemistry. 118:1016-1031
J. Neurochem. (2011) 118, 1016–1031. Abstract The EphA4 receptor and its ephrin ligands are involved in astrocytic gliosis following CNS injury. Therefore, a strategy aimed at the blockade of EphA4 signaling could have broad therapeutic interest in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::774b2b64017b3070dd5d4ff035e305f6
https://doi.org/10.1111/j.1471-4159.2011.07375.x
https://doi.org/10.1111/j.1471-4159.2011.07375.x
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery. :447-828
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bc66c41b88751f7519ba55d3cd19120
https://doi.org/10.1002/0471266949.bmc250
https://doi.org/10.1002/0471266949.bmc250
Autor:
John Swestock, Ming Tain Lai, Shaun R. Stauffer, Sanjeev Munshi, Georgia B. McGaughey, Joseph P. Vacca, Marie A. Holahan, Keith P. Moore, Dennis Colussi, Hemaka A. Rajapakse, Mathew G. Stanton, Maria S. Michener, Jacquelynn J. Cook, Allison R. Gregro, Philippe G. Nantermet, Sethu Sankaranarayanan, James C. Barrow, Harold G. Selnick, Adam J. Simon, Melissa A. Steinbeiser, Samuel L. Graham
Publikováno v:
ChemMedChem. 4:37-40
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce223e5a433ee926f9648f0ab8df86b7
https://doi.org/10.1002/cmdc.200800308
https://doi.org/10.1002/cmdc.200800308
Autor:
Janet Lineberger, Matthew G. Stanton, Amy S. Espeseth, Beth Pietrak, Min Xu, Katherine Tugusheva, Harold G. Selnick, Dennis Colussi, Guy R. Seabrook, John Swestock, Jason Kahana, Ming-Chih Crouthamel, Viswanath Devanarayan, Keala X. Tyler, Guoxin Wu, Daria J. Hazuda, Shaun R. Stauffer, Joan D. Ellis, Marie A. Holahan, Joseph P. Vacca, Philippe G. Nantermet, Melissa A. Steinbeiser, Georgia B. McGaughey, Eric A. Price, Jerome Hochman, Hemaka A. Rajapakse, Sethu Sankaranarayanan, Adam J. Simon, Samuel L. Graham, Keith P. Moore, M. Katharine Holloway, Ming-Tain Lai, Lixia Jin, Adam Gates, Xiao-Ping Shi, Jacky Wong, Jacquelynn J. Cook, Allison R. Gregro
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 328:131-140
beta-Site amyloid precursor protein (APP)-cleaving enzyme (BACE) 1 cleavage of amyloid precursor protein is an essential step in the generation of the potentially neurotoxic and amyloidogenic A beta 42 peptides in Alzheimer's disease. Although previo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01219a959e3def2dc15d6af0a2e96474
https://doi.org/10.1124/jpet.108.143628
https://doi.org/10.1124/jpet.108.143628