Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Philippe Funes"'
Publikováno v:
European Journal of Organic Chemistry. 2005:3360-3369
The aim of this research was to discover α2-receptor antagonist subtypes that are more selective than known compounds. We focused on rigid molecules possessing a benzo-fused bicyclo[3.2.0]heptane skeleton. The synthetic route used relied upon the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d95fc712f3c0740ea29a07a11d701015
https://doi.org/10.1002/ejoc.200500143
https://doi.org/10.1002/ejoc.200500143
Autor:
Nathalie Jubault, Wouter Koek, Cristina Cosi, Bernard Bonnaud, Bernard Vacher, Philippe Funes, Mark S. Kleven, Marie Bernadette Assié
Publikováno v:
Journal of Medicinal Chemistry. 42:1648-1660
The aim of this work was to improve the oral bioavailability of a recently discovered, novel structural class of 5-HT1A receptor agonists: aryl-{[4-(6-R-pyridin-2-ylmethyl)-amino]-methyl}-piperidin-1 -yl-metha none. Incorporation of a fluorine atom i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a825f2a4eeffbc520598690040c02770
https://doi.org/10.1021/jm9806906
https://doi.org/10.1021/jm9806906
Autor:
Bernard Bonnaud, Cristina Cosi, Bernard Vacher, Wouter Koek, Philippe Funes, Marie Bernadette Assié, Nathalie Jubault
Publikováno v:
Journal of Medicinal Chemistry. 41:5070-5083
A search for novel, selective agonists with high intrinsic activity at the 5-HT1A subtype of serotonin (5-HT) receptors was undertaken. Mechanistic and thermodynamic considerations led to the design of 6-substituted-2-pyridinylmethylamine as a potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cdf87e9728cabef6e6703a4844ee5fa
https://doi.org/10.1021/jm9804329
https://doi.org/10.1021/jm9804329
Autor:
Philippe Funes, Bernard Vacher, Peter Heusler, Marc Marien, Amélie Tourette, Philippe Chopin, Didier Cussac
Publikováno v:
Journal of medicinal chemistry. 53(19)
We report the discovery of a new family of α(2) adrenergic receptor antagonists derived from atipamezole. Affinities of the compounds at human α(2) and α(1b) receptors as well as their functional activities at hα(2A) receptors were determined in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6206eaeb4ef1b1bdfa46eb9bd584985
https://pubmed.ncbi.nlm.nih.gov/20809632
https://pubmed.ncbi.nlm.nih.gov/20809632
Autor:
Philippe Funes, Bernard Bonnaud, Wouter Koek, Nathalie Jubault, Bernard Vacher, Cristina Cosi, Marie Bernadette Assié
Publikováno v:
ChemInform. 30
A search for novel, selective agonists with high intrinsic activity at the 5-HT1A subtype of serotonin (5-HT) receptors was undertaken. Mechanistic and thermodynamic considerations led to the design of 6-substituted-2-pyridinylmethylamine as a potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ba458fa98eddc81013edecaa2bd0b78
https://doi.org/10.1002/chin.199917141
https://doi.org/10.1002/chin.199917141
Autor:
Adrian Newman-Tancredi, Bernard Vacher, Francis Colpaert, Jean Louis Maurel, Philippe Funes, Jean-Marie Autin
Publikováno v:
Journal of medicinal chemistry. 50(20)
We report the discovery of novel 5-HT1A receptor agonists and describe the process that led to the antidepressant candidate 9 (F 15599). 9 has nanomolar affinity for 5-HT1A binding sites and is over 1000-fold selective with respect to the other 5-HT1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2e915c93311e0b1be03969cd950e5e
https://pubmed.ncbi.nlm.nih.gov/17803293
https://pubmed.ncbi.nlm.nih.gov/17803293
Autor:
Bernard Vacher, Philippe Funes, Philippe Chopin, Didier Cussac, Peter Heusler, Amelie Tourette, Marc Marien
Publikováno v:
Journal of Medicinal Chemistry; Oct2010, Vol. 53 Issue 19, p6986-6995, 10p
Autor:
Jean Louis Maurel, Jean-Marie Autin, Philippe Funes, Adrian Newman-Tancredi, Francis Colpaert, Bernard Vacher
Publikováno v:
Journal of Medicinal Chemistry; Oct2007, Vol. 50 Issue 20, p5024-5033, 10p
Publikováno v:
European Journal of Organic Chemistry; Aug2005, Vol. 2005 Issue 15, p3360-3369, 10p