Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Philippe F.Y. Vincent"'
1
Akademický článek
Engineering olivocochlear inhibition to reduce acoustic trauma
Autor: Yuanyuan Zhang, Hakim Hiel, Philippe F.Y. Vincent, Megan B. Wood, Ana B. Elgoyhen, Wade Chien, Amanda Lauer, Paul A. Fuchs
Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 17-31 (2023)
Efferent brain-stem neurons release acetylcholine to desensitize cochlear hair cells and can protect the inner ear from acoustic trauma. That protection is absent from knockout mice lacking efferent inhibition and is stronger in mice with a gain-of-f
Externí odkaz: https://doaj.org/article/a79bc30c2bc9499087ccecdc63b17e25
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2
Akademický článek
Clustered Ca2+ Channels Are Blocked by Synaptic Vesicle Proton Release at Mammalian Auditory Ribbon Synapses
Autor: Philippe F.Y. Vincent, Soyoun Cho, Margot Tertrais, Yohan Bouleau, Henrique von Gersdorff, Didier Dulon
Publikováno v: Cell Reports, Vol 25, Iss 12, Pp 3451-3464.e3 (2018)
Summary: A Ca2+ current transient block (ICaTB) by protons occurs at some ribbon-type synapses after exocytosis, but this has not been observed at mammalian hair cells. Here we show that a robust ICaTB occurs at post-hearing mouse and gerbil inner ha
Externí odkaz: https://doaj.org/article/70812dc1c6a64df6b033b6d258261cf8
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3
Different CaV1.3 Channel Isoforms Control Distinct Components of the Synaptic Vesicle Cycle in Auditory Inner Hair Cells
Autor: Didier Dulon, Philippe F.Y. Vincent, Yohan Bouleau, Gilles Charpentier, Saaid Safieddine, Alice Emptoz, Christine Petit
Publikováno v: Journal of Neuroscience
Journal of Neuroscience, 2017, 37 (11), pp.2960-2975. ⟨10.1523/JNEUROSCI.2374-16.2017⟩
The mechanisms orchestrating transient and sustained exocytosis in auditory inner hair cells (IHCs) remain largely unknown. These exocytotic responses are believed to mobilize sequentially a readily releasable pool of vesicles (RRP) underneath the sy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f820aef03b8b8fe6b410b0fc01129208
https://doi.org/10.1523/jneurosci.2374-16.2017
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4
Clarin-1 gene transfer rescues auditory synaptopathy in model of Usher syndrome
Autor: Omar Akil, Didier Dulon, Samantha Papal, Vincent Michel, Paul Avan, Alice Emptoz, Aziz El-Amraoui, Olinda Alegria-Prévot, Sedigheh Delmaghani, Pranav Patni, Lawrence R. Lustig, Christine Petit, Alain Aghaie, Abdelaziz Tlili, Elise Pepermans, Yohan Bouleau, Saaid Safieddine, Margot Tertrais, Matteo Cortese, Philippe F.Y. Vincent
Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, 2018, 128 (8), pp.3382-3401. ⟨10.1172/JCI94351⟩
Journal of Clinical Investigation, American Society for Clinical Investigation, 2018, 128 (8), pp.3382-3401. 〈10.1172/JCi94351〉
Journal of Clinical Investigation, American Society for Clinical Investigation, 2018, 128 (8), pp.3382-3401. ⟨10.1172/JCI94351⟩
The journal of clinical investigation
Clarin-1, a tetraspan-like membrane protein defective in Usher syndrome type IIIA (USH3A), is essential for hair bundle morphogenesis in auditory hair cells. We report a new synaptic role for clarin-1 in mouse auditory hair cells elucidated by charac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::442a4774c92de44a660e270a911cd4e4
https://hal-pasteur.archives-ouvertes.fr/pasteur-01858480/file/Dulon_ElAmraoui_2017.pdf
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5
Clustered Ca 2 Channels are Blocked by Synaptic Vesicle Proton Release at Mammalian Auditory Ribbon Synapses
Autor: Margot Tertrais, Didier Dulon, Henrique von Gersdorff, Yohan Bouleau, Soyoun Cho, Philippe F.Y. Vincent
Publikováno v: SSRN Electronic Journal.
A Ca2+ current transient block (ICaTB) by protons occurs at some ribbon-type synapses after exocytosis, however this has not been observed at mammalian hair cells. Here we show that a robust ICaTB occurs at post-hearing mouse and gerbil inner hair ce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e8502996b100dd2b3aeef2a6d6d9199
https://doi.org/10.2139/ssrn.3257348
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6
Clustered Ca2+ Channels Are Blocked by Synaptic Vesicle Proton Release at Mammalian Auditory Ribbon Synapses
Autor: Yohan Bouleau, Didier Dulon, Margot Tertrais, Soyoun Cho, Philippe F.Y. Vincent, Henrique von Gersdorff
Publikováno v: Cell Reports, Vol 25, Iss 12, Pp 3451-3464.e3 (2018)
Summary: A Ca2+ current transient block (ICaTB) by protons occurs at some ribbon-type synapses after exocytosis, but this has not been observed at mammalian hair cells. Here we show that a robust ICaTB occurs at post-hearing mouse and gerbil inner ha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd243deb10df91f0e58e18d69930cfb
https://doi.org/10.1016/j.celrep.2018.11.072
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8
A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells
Autor: Yohan Bouleau, Christine Petit, Didier Dulon, Philippe F.Y. Vincent
Publikováno v: eLife
eLife, 2015, 4, pp.e10988. ⟨10.7554/eLife.10988⟩
eLife, eLife Sciences Publication, 2015, 4, pp.e10988. ⟨10.7554/eLife.10988⟩
eLife, Vol 4 (2015)
We show that a cage-shaped F-actin network is essential for maintaining a tight spatial organization of Cav1.3 Ca2+ channels at the synaptic ribbons of auditory inner hair cells. This F-actin network is also found to provide mechanosensitivity to the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::215b2d956c42f57564d6575f4e0222e6
https://hal.sorbonne-universite.fr/hal-01312800
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9
Exocytotic machineries of vestibular type I and cochlear ribbon synapses display similar intrinsic otoferlin-dependent Ca2+ sensitivity but a different coupling to Ca2+ channels
Autor: Yohan Bouleau, Didier Dulon, Christine Petit, Saaid Safieddine, Philippe F.Y. Vincent
Publikováno v: Journal of Neuroscience
Journal of Neuroscience, 2014, 34 (33), pp.10853-10869. ⟨10.1523/JNEUROSCI.0947-14.2014⟩
International audience; The hair cell ribbon synapses of the mammalian auditory and vestibular systems differ greatly in their anatomical organization and firing properties. Notably, vestibular Type I hair cells (VHC-I) are surrounded by a single cal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1d03ac7d30b192c378390fbf59a1b8
https://pubmed.ncbi.nlm.nih.gov/25122888
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