Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Philippe E Van den Steen"'
Autor:
Emilie Pollenus, Hendrik Possemiers, Sofie Knoops, Fran Prenen, Leen Vandermosten, Chloë Thienpont, Saeed Abdurahiman, Sofie Demeyer, Jan Cools, Gianluca Matteoli, Jeroen A J Vanoirbeek, Greetje Vande Velde, Philippe E Van den Steen
Publikováno v:
PLoS Pathogens, Vol 20, Iss 1, p e1011929 (2024)
Plasmodium parasites cause malaria, a global health disease that is responsible for more than 200 million clinical cases and 600 000 deaths each year. Most deaths are caused by various complications, including malaria-associated acute respiratory dis
Externí odkaz:
https://doaj.org/article/e58f5cf4cbf44278908ea85b13b37555
Autor:
Hendrik Possemiers, Thao-Thy Pham, Marion Coens, Emilie Pollenus, Sofie Knoops, Sam Noppen, Leen Vandermosten, Sigrid D'haese, Luna Dillemans, Fran Prenen, Dominique Schols, Blandine Franke-Fayard, Philippe E Van den Steen
Publikováno v:
PLoS Pathogens, Vol 17, Iss 11, p e1010114 (2021)
Malaria is a hazardous disease caused by Plasmodium parasites and often results in lethal complications, including malaria-associated acute respiratory distress syndrome (MA-ARDS). Parasite sequestration in the microvasculature is often observed, but
Externí odkaz:
https://doaj.org/article/18476ed9c37141adacf318dc11721d7b
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009122 (2021)
Lactic acidosis and hyperlactatemia are common metabolic disturbances in patients with severe malaria. Lactic acidosis causes physiological adverse effects, which can aggravate the outcome of malaria. Despite its clear association with mortality in m
Externí odkaz:
https://doaj.org/article/3677a1178d00456d93e15547a39da447
Autor:
Karolina A Zielinska, Laura Van Moortel, Ghislain Opdenakker, Karolien De Bosscher, Philippe E Van Den Steen
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
The endothelium plays a crucial role in inflammation. A balanced control of inflammation requires the action of glucocorticoids (GCs), steroidal hormones with potent cell-specific anti-inflammatory properties. Besides the classic anti-inflammatory ef
Externí odkaz:
https://doaj.org/article/7de96e15fdf3402aa02bbb81d7cd891c
Autor:
Diletta Scaccabarozzi, Katrien Deroost, Natacha Lays, Fausta Omodeo Salè, Philippe E Van den Steen, Donatella Taramelli
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0143195 (2015)
Malaria-associated acute lung injury (MA-ALI) and its more severe form malaria-associated acute respiratory distress syndrome (MA-ARDS) are common, often fatal complications of severe malaria infections. However, little is known about their pathogene
Externí odkaz:
https://doaj.org/article/bddc3e25876a416686f837bfb8e3b333
Autor:
Jessica Filtjens, Lander Foquet, Sylvie Taveirne, Els Van Ammel, Mandy Vanhees, Aline Van Acker, Tessa Kerre, Tom Taghon, Bart Vandekerckhove, Jean Plum, Philippe E Van den Steen, Georges Leclercq
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87463 (2014)
Natural killer (NK) cells have different roles in the host response against Plasmodium-induced malaria depending on the stage of infection. Liver NK cells have a protective role during the initial hepatic stage of infection by production of the TH1-t
Externí odkaz:
https://doaj.org/article/cf14b117e1c04dbd926364f727e288e2
Autor:
Katrien Deroost, Natacha Lays, Thao-Thy Pham, Denisa Baci, Kathleen Van den Eynde, Mina Komuta, Mauro Prato, Tania Roskams, Evelin Schwarzer, Ghislain Opdenakker, Philippe E Van den Steen
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e113519 (2014)
Malaria is a global disease that clinically affects more than two hundred million people annually. Despite the availability of effective antimalarials, mortality rates associated with severe complications are high. Hepatopathy is frequently observed
Externí odkaz:
https://doaj.org/article/4e039a06aff940098312ba3e8cdcdfa2
Autor:
Manuela Polimeni, Elena Valente, Daniela Ulliers, Ghislain Opdenakker, Philippe E Van den Steen, Giuliana Giribaldi, Mauro Prato
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71468 (2013)
Recently matrix metalloproteinase-9 (MMP-9) and its endogenous inhibitor (tissue inhibitor of metalloproteinase-1, TIMP-1) have been implicated in complicated malaria. In vivo, mice with cerebral malaria (CM) display high levels of both MMP-9 and TIM
Externí odkaz:
https://doaj.org/article/9a6272af662b4874bddd8901ffae1560
Autor:
Nathalie Geurts, Erik Martens, Sebastien Verhenne, Natacha Lays, Greet Thijs, Stefan Magez, Bénédicte Cauwe, Sandra Li, Hubertine Heremans, Ghislain Opdenakker, Philippe E Van den Steen
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27131 (2011)
The use of genetically modified mice, i.e. transgenic as well as gene knockout (KO) and knock-in mice, has become an established tool to study gene function in many animal models for human diseases. However, a gene functions in a particular genomic c
Externí odkaz:
https://doaj.org/article/17c23f85bcdb468db28ebdc787e462a0
Autor:
Gabriel Rosenblum, Philippe E Van den Steen, Sidney R Cohen, Arkady Bitler, David D Brand, Ghislain Opdenakker, Irit Sagi
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11043 (2010)
Enzymatic processing of extracellular matrix (ECM) macromolecules by matrix metalloproteases (MMPs) is crucial in mediating physiological and pathological cell processes. However, the molecular mechanisms leading to effective physiological enzyme-ECM
Externí odkaz:
https://doaj.org/article/e71aeca16b1d4383a579ce21a040cd4e