Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Philippe E Mangeot"'
Autor:
Isabel Pombo Grégoire, Clémence Richetta, Laurène Meyniel-Schicklin, Sophie Borel, Fabrine Pradezynski, Olivier Diaz, Alexandre Deloire, Olga Azocar, Joël Baguet, Marc Le Breton, Philippe E Mangeot, Vincent Navratil, Pierre-Emmanuel Joubert, Monique Flacher, Pierre-Olivier Vidalain, Patrice André, Vincent Lotteau, Martine Biard-Piechaczyk, Chantal Rabourdin-Combe, Mathias Faure
Publikováno v:
PLoS Pathogens, Vol 7, Iss 12, p e1002422 (2011)
Autophagy is a conserved degradative pathway used as a host defense mechanism against intracellular pathogens. However, several viruses can evade or subvert autophagy to insure their own replication. Nevertheless, the molecular details of viral inter
Externí odkaz:
https://doaj.org/article/f522e87acc8f40f39a32b6dfbd15fc1a
Autor:
Caroline Vindry, Olivia Guillin, Philippe Wolff, Paul Marie, Franck Mortreux, Philippe E Mangeot, Théophile Ohlmann, Laurent Chavatte
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 2023, ⟨10.1093/nar/gkad482⟩
Nucleic Acids Research, 2023, ⟨10.1093/nar/gkad482⟩
The selenocysteine (Sec) tRNA (tRNA[Ser]Sec) governs Sec insertion into selenoproteins by the recoding of a UGA codon, typically used as a stop codon. A homozygous point mutation (C65G) in the human tRNA[Ser]Sec acceptor arm has been reported by two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63539fc597931f08e32ae5f0318ae7f
https://hal.science/hal-04136959/document
https://hal.science/hal-04136959/document
Autor:
Victor Tirolle, Adrien Krug, Emma Bokobza, Mattijs Bulcaen, Marjolein M. Ensinck, Maarten H. Geurts, Delilah Hendriks, François Vermeulen, Frédéric Larbret, Alejandra Gutierrez-Guerrero, Louise Medaer, Rik Gijsbers, Philippe E. Mangeot, Hans Clevers, Marianne S. Carlon, Frederic Bost, Els Verhoeyen
Genome engineering has become more accessible thanks to the RNA programmable endonucleases such as the CRISPR/Cas9 system. However, using this editing technology in synthetic organs called ‘organoids’ is still very inefficient. This is due to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd862d8b5bbe9ad027009690e7538a3b
https://doi.org/10.1101/2022.08.04.502859
https://doi.org/10.1101/2022.08.04.502859
Publikováno v:
Cells, Vol 8, Iss 6, p 574 (2019)
The translation of selenoprotein mRNAs involves a non-canonical ribosomal event in which an in-frame UGA is recoded as a selenocysteine (Sec) codon instead of being read as a stop codon. The recoding machinery is centered around two dedicated RNA com
Externí odkaz:
https://doaj.org/article/b4f223641178404fa72f0ad99576a24b
Publikováno v:
Journal of visualized experiments : JoVE. (169)
The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas system has democratized genome-editing in eukaryotic cells and led to the development of numerous innovative applications. However, delivery of the Cas9 protein and single-gui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::50ce44de1a2a107a556948457493f9d9
https://pubmed.ncbi.nlm.nih.gov/33871447
https://pubmed.ncbi.nlm.nih.gov/33871447
Autor:
Gaëlle Legube, Thomas Clouaire, Vincent Rocher, Philippe E. Mangeot, Pierre Caron, Felix Zhou, Raphaël Mourad, James E. Haber, Coline Arnould, Daan Noordermeer, Kevin Li, Anne-Laure Finoux, Emiliano P. Ricci
Publikováno v:
Nature
Nature, Nature Publishing Group, 2021, 590 (7847), pp.660-665. ⟨10.1038/s41586-021-03193-z⟩
Nature, 2021, 590 (7847), pp.660-665. ⟨10.1038/s41586-021-03193-z⟩
Nature, Nature Publishing Group, 2021, 590 (7847), pp.660-665. ⟨10.1038/s41586-021-03193-z⟩
Nature, 2021, 590 (7847), pp.660-665. ⟨10.1038/s41586-021-03193-z⟩
The repair of DNA double-strand breaks (DSBs) is essential for safeguarding genome integrity. When a DSB forms, the PI3K-related ATM kinase rapidly triggers the establishment of megabase-sized, chromatin domains decorated with phosphorylated histone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ccd97d6413cb965ab452c3e3dff334b
https://hal.archives-ouvertes.fr/hal-03385752/document
https://hal.archives-ouvertes.fr/hal-03385752/document
Autor:
Gaël Yvert, Théophile Ohlmann, Hélène Duplus-Bottin, Christophe Place, Gérard Triqueneaux, Philippe E. Mangeot, Martin Spichty, Franck Vittoz
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife, 2021, 10, ⟨10.7554/eLife.61268⟩
eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/eLife.61268⟩
eLife
eLife, 2021, 10, ⟨10.7554/eLife.61268⟩
eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/eLife.61268⟩
Optogenetics enables genome manipulations with high spatiotemporal resolution, opening exciting possibilities for fundamental and applied biological research. Here, we report the development of LiCre, a novel light-inducible Cre recombinase. LiCre is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cab58b3e9bc419f4f12f4303e2f78968
https://doi.org/10.7554/elife.61268
https://doi.org/10.7554/elife.61268
Autor:
Alejandra Gutierrez-Guerrero, Maria Jimena Abrey Recalde, Philippe E. Mangeot, Caroline Costa, Ornellie Bernadin, Séverine Périan, Floriane Fusil, Gisèle Froment, Adriana Martinez-Turtos, Adrien Krug, Francisco Martin, Karim Benabdellah, Emiliano P. Ricci, Simone Giovannozzi, Rik Gijsbers, Eduard Ayuso, François-Loïc Cosset, Els Verhoeyen
Publikováno v:
Frontiers in Genome Editing, Vol 3 (2021)
Programmable nucleases have enabled rapid and accessible genome engineering in eukaryotic cells and living organisms. However, their delivery into human blood cells can be challenging. Here, we have utilized “nanoblades,” a new technology that de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::7fd14bf356d6b31ec56c6b73d3826997
https://www.frontiersin.org/articles/10.3389/fgeed.2021.604371/full
https://www.frontiersin.org/articles/10.3389/fgeed.2021.604371/full
Autor:
Gaël Yvert, Hélène Duplus-Bottin, Franck Vittoz, Gérard Triqueneaux, Théophile Ohlmann, Christophe Place, Martin Spichty, Philippe E. Mangeot
Optogenetics enables genome manipulations with high spatiotemporal resolution, opening exciting possibilities for fundamental and applied biological research. Here, we report the development of LiCre, a novel light-inducible Cre recombinase. LiCre is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33add42664329c39dffb8b044d17844
https://hal.science/hal-03055036/document
https://hal.science/hal-03055036/document
Autor:
Thomas Clouaire, Emiliano P. Ricci, Pierre Caron, Daan Noordermeer, Philippe E. Mangeot, Gaëlle Legube, Coline Arnould, Raphaël Mourad, Rocher
DNA Double-Strand Breaks (DSBs) repair is essential to safeguard genome integrity. Upon DSBs, the ATM PI3K kinase rapidly triggers the establishment of megabase-sized, γH2AX-decorated chromatin domains which further act as seeds for the formation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c05cd15148a480506d5ae9d45f1b29a
https://hal.archives-ouvertes.fr/hal-02991048/file/2020.02.12.945311v1.full.pdf
https://hal.archives-ouvertes.fr/hal-02991048/file/2020.02.12.945311v1.full.pdf