Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Philippe Dagneau"'
Publikováno v:
Angewandte Chemie International Edition. 47:8605-8610
Vannusals A (1a, Figure 1) and B (1b) are two marine natural products notable for their unusual molecular architectures. Isolated from the tropical interstitial ciliate Euplotes vannus strains Si121 and BUN3, these intriguing molecules include in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e0f6a7615d6ededa6015319beac1cc
https://doi.org/10.1002/anie.200804228
https://doi.org/10.1002/anie.200804228
Publikováno v:
Angewandte Chemie. 120:8733-8738
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8be9b5d21cbac7f689b11ed6205288b
https://doi.org/10.1002/ange.200804228
https://doi.org/10.1002/ange.200804228
Publikováno v:
Angewandte Chemie International Edition. 44:3874-3879
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520a9beed2c25f1b344de661ec6b3da0
https://doi.org/10.1002/anie.200500789
https://doi.org/10.1002/anie.200500789
Autor:
Edward J. J. Grabowski, Karen Marcantonio, Amélie Roy, Dalian Zhao, Lushi Tan, Lisa F. Frey, Cheng-yi Chen, Richard D. Tillyer, Philippe Dagneau, Paul D. O’Shea, Xin Wang, Robert A. Reamer, Weirong Chen
Publikováno v:
The Journal of Organic Chemistry. 70:3021-3030
A practical, chromatography-free catalytic asymmetric synthesis of a potent and selective PDE4 inhibitor (L-869,298, 1) is described. Catalytic asymmetric hydrogenation of thiazole ketone 5a afforded the corresponding alcohol 3b in excellent enantios
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f04f04a3c82fadcb9efea44c3f787ae1
https://doi.org/10.1021/jo048156v
https://doi.org/10.1021/jo048156v
Autor:
Xin Wang, Joel Robichaud, Peppi Prasit, Cheng-yi Chen, Renata Oballa, Edward J. J. Grabowski, R. D. Tillyer, Philippe Dagneau, Paul D. O’Shea
Publikováno v:
The Journal of Organic Chemistry. 68:2633-2638
A large-scale, chromatography-free synthesis of a potent and selective Cathepsin K inhibitor 1 is reported. The key asymmetric center was installed by addition of (R)-pantolactone to the in situ-generated ketene 4a. The final step of the convergent s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2095c7eeccb2bed53fbb935573722dff
https://doi.org/10.1021/jo0205614
https://doi.org/10.1021/jo0205614
Autor:
Xin Wang, Weirong Chen, Lushi Tan, Paul J. Reider, Lisa F. Frey, Philippe Dagneau, Anthony O. King, Cheng-yi Chen, Richard D. Tillyer, Feng Xu, Edward J. J. Grabowski, Paul D. O’Shea, Dalian Zhao
Publikováno v:
Tetrahedron. 58:7403-7410
Two synthetic strategies to the COX-2 specific inhibitor 1 have been described that allowed its preparation in large quantities in 79% overall yield from (S)-2-hydroxy-2-methylbutyric acid. These studies have led to the identification of an efficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cd182f902592f23e2a50832948894e6
https://doi.org/10.1016/s0040-4020(02)00826-8
https://doi.org/10.1016/s0040-4020(02)00826-8
Autor:
Sarah Stahl, Xin Wang, Richard D. Tillyer, Philippe Dagneau, Paul D. O’Shea, Anthony O. King, Michel Chartrain, Randolph Greasham
Publikováno v:
Biocatalysis and Biotransformation. 18:471-477
The screening of 144 microbial strains yielded several suitable biocatalysts for the asymmetric bioreduction of an allylic ketosulfone to its corresponding (R)-alcohol. The production of the desired enantiomer with elevated optical purity (ee > 90%)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbe6f79d7b878c2f8061566a1425c111
https://doi.org/10.3109/10242420009015264
https://doi.org/10.3109/10242420009015264
Autor:
Philippe Dagneau, Persephone Canonne
Publikováno v:
Tetrahedron: Asymmetry. 7:2817-2820
Pulegone was used for the first total synthesis of (+)-fulvanin 1 adopting chiron approach. Pertinent methodology includes stereocontrolled Michael-type reaction, functional group adjustements and Wittig olefination.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25f75884d57b3a45f47280b865a29685
https://doi.org/10.1016/0957-4166(96)00370-9
https://doi.org/10.1016/0957-4166(96)00370-9
Autor:
Yao-Jun Shi, Benjamin Marcune, Donald R. Gauthier, Philippe Dagneau, John Y. L. Chung, Shane W. Krska, Mark McLaughlin, Robert A. Reamer, Nobuyoshi Yasuda, Yong-Li Zhong, Richard G. Ball
Publikováno v:
The Journal of organic chemistry. 77(7)
An efficient, new, and scalable semisynthesis of glucan synthase inhibitors 1 and 2 from the fermentation product enfumafungin 3 is described. The highlights of the synthesis include a high-yielding ether bond-forming reaction between a bulky sulfami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e4965ae37c1927ae8ccc6beda5bf67
https://pubmed.ncbi.nlm.nih.gov/22423625
https://pubmed.ncbi.nlm.nih.gov/22423625
Autor:
Philippe Dagneau, Dimitrios E. Lizos, Stellios Arseniyadis, Kyriacos C. Nicolaou, Raffaella Faraoni, Andreas Lanver, Adrian Ortiz, Hongjun Zhang, Michael P. Jennings
Publikováno v:
ChemInform. 41
The total synthesis of the originally assigned structure of vannusal B (2) and its diastereomer (d-2) are described. Initial forays into these structures with model systems revealed the viability of a metathesis-based approach and a SmI2-mediated str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86ce99c1991ca9ff39dfb12c05987684
https://doi.org/10.1002/chin.201037181
https://doi.org/10.1002/chin.201037181