Active mRNA degradation by EXD2 nuclease elicits recovery of transcription after genotoxic stress

Autor: Jérémy Sandoz, Max Cigrang, Amélie Zachayus, Philippe Catez, Lise-Marie Donnio, Clèmence Elly, Jadwiga Nieminuszczy, Pietro Berico, Cathy Braun, Sergey Alekseev, Jean-Marc Egly, Wojciech Niedzwiedz, Giuseppina Giglia-Mari, Emmanuel Compe, Frédéric Coin

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Here the authors show that the exonuclease EXD2 is involved in the recovery of class II gene transcription after UV irradiation. EXD2 travels from the mitochondria to the nucleus to interact with RNA Pol II and degrade new synthetized mRNA to allow t

Externí odkaz: https://doaj.org/article/a0d3f932123e4cc6bc846c308c77597d

Dynamic partnership between TFIIH, PGC-1α and SIRT1 is impaired in trichothiodystrophy.

Autor: Hussein Traboulsi, Serena Davoli, Philippe Catez, Jean-Marc Egly, Emmanuel Compe

Publikováno v: PLoS Genetics, Vol 10, Iss 10, p e1004732 (2014)

The expression of protein-coding genes requires the selective role of many transcription factors, whose coordinated actions remain poorly understood. To further grasp the molecular mechanisms that govern transcription, we focused our attention on the

Externí odkaz: https://doaj.org/article/d0105cf9646142f095af1cd13188f5b2

Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression

Autor: Jean-Baptiste Renaud, Jérémy Sandoz, Jean-Paul Concordet, Philippe Catez, Sylvain Geny, Laszlo Tora, Gizem Caliskan, Arnaud Poterszman, Nicolas Le May, Jean-Marc Egly, Zita Nagy, Frédéric Coin

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-09270-2⟩
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-019-09270-2⟩
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.1288. ⟨10.1038/s41467-019-09270-2⟩

The TFIIH subunit XPB is involved in combined Xeroderma Pigmentosum and Cockayne syndrome (XP-B/CS). Our analyses reveal that XPB interacts functionally with KAT2A, a histone acetyltransferase (HAT) that belongs to the hSAGA and hATAC complexes. XPB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2af59dd46589be04d58d71b39649911
https://hal.archives-ouvertes.fr/hal-03092036

Dynamic Partnership between TFIIH, PGC-1α and SIRT1 Is Impaired in Trichothiodystrophy

Autor: Emmanuel Compe, Philippe Catez, Jean-Marc Egly, Serena Davoli, Hussein Traboulsi

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 10, Iss 10, p e1004732 (2014)

The expression of protein-coding genes requires the selective role of many transcription factors, whose coordinated actions remain poorly understood. To further grasp the molecular mechanisms that govern transcription, we focused our attention on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61dff36bc5a6c4fc58751697a7e036ec
http://europepmc.org/articles/PMC4207666

Functional Interactions between C/EBP, Sp1, and COUP-TF Regulate Human Immunodeficiency Virus Type 1 Gene Transcription in Human Brain Cells

Autor: Philippe Catez, Dominique Aunis, Dominique Lecestre, Olivier Rohr, Christian Schwartz, Evelyne Schaeffer

Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2000, 74 (1), pp.65-73. ⟨10.1128/JVI.74.1.65-73.2000⟩

Human immunodeficiency virus type 1 (HIV-1) infects the central nervous system (CNS) and plays a direct role in the pathogenesis of AIDS dementia. However, mechanisms underlying HIV-1 gene expression in the CNS are poorly understood. The importance o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c070ce9a35310c8c252ada0b2291383
http://jvi.asm.org/cgi/doi/10.1128/JVI.74.1.65-73.2000