Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Philippe C Després"'
Publikováno v:
PLoS Pathogens, Vol 20, Iss 9, p e1012478 (2024)
Externí odkaz:
https://doaj.org/article/a39ab6d48c074c9d81c58ec509ca4087
Autor:
Francois D Rouleau, Alexandre K Dubé, Isabelle Gagnon-Arsenault, Soham Dibyachintan, Alicia Pageau, Philippe C Després, Patrick Lagüe, Christian R Landry
Publikováno v:
PLoS Genetics, Vol 20, Iss 4, p e1011252 (2024)
Pneumocystis jirovecii is a fungal pathogen that causes pneumocystis pneumonia, a disease that mainly affects immunocompromised individuals. This fungus has historically been hard to study because of our inability to grow it in vitro. One of the main
Externí odkaz:
https://doaj.org/article/02de62579ea74a79aa374817d42790d2
Autor:
Ugo Dionne, Émilie Bourgault, Alexandre K. Dubé, David Bradley, François J. M. Chartier, Rohan Dandage, Soham Dibyachintan, Philippe C. Després, Gerald D. Gish, N. T. Hang Pham, Myriam Létourneau, Jean-Philippe Lambert, Nicolas Doucet, Nicolas Bisson, Christian R. Landry
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The SRC Homology 3 (SH3) domains mediate protein–protein interactions (PPIs). Here, the authors assess the SH3-mediated PPIs in yeast, and show that the identity of the protein itself and the position of the SH3 both affect the interaction specific
Externí odkaz:
https://doaj.org/article/3eb0d24dbb7e42d98c601ea7d75ada6a
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Base editors allow for the precise modification of genes. Here the authors use Target-AID to systematically test 17,000 sites across the yeast genome.
Externí odkaz:
https://doaj.org/article/b227619047ad4389a7f03d66669a8b2b
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 10, Pp 3163-3171 (2018)
CRISPR-Cas9 loss of function (LOF) and base editing screens are powerful tools in genetics and genomics. Yeast is one of the main models in these fields, but has only recently started to adopt this new toolkit for high throughput experiments. We deve
Externí odkaz:
https://doaj.org/article/79c2f48edabe4b9da7159ffb16afbafe
Autor:
Philippe C. Després, Angel F. Cisneros, Emilie M. M. Alexander, Ria Sonigara, Cynthia Gagné-Thivierge, Alexandre K. Dubé, Christian R. Landry
Publikováno v:
Nature Ecology & Evolution. 6:1501-1515
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9741121c4e02fec69f726b8cdb497cbd
https://doi.org/10.1038/s41559-022-01846-4
https://doi.org/10.1038/s41559-022-01846-4
Autor:
Rohan Dandage, Nicolas Doucet, Myriam Létourneau, François J.M. Chartier, Gerald D. Gish, Nicolas Bisson, Jean-Philippe Lambert, Ugo Dionne, N. T. Hang Pham, Alexandre K. Dubé, Christian R. Landry, Soham Dibyachintan, Émilie Bourgault, David Bradley, Philippe C Després
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Protein–protein interactions (PPIs) between modular binding domains and their target peptide motifs are thought to largely depend on the intrinsic binding specificities of the domains. The large family of SRC Homology 3 (SH3) domains contribute to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c091dc5126a3fb3f23bb36095a0065a
https://doaj.org/article/3eb0d24dbb7e42d98c601ea7d75ada6a
https://doaj.org/article/3eb0d24dbb7e42d98c601ea7d75ada6a
Autor:
Alexandre K, Dubé, Rohan, Dandage, Soham, Dibyachintan, Ugo, Dionne, Philippe C, Després, Christian R, Landry
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2477
Deep mutational scanning (DMS) generates mutants of a protein of interest in a comprehensive manner. CRISPR-Cas9 technology enables large-scale genome editing with high efficiency. Using both DMS and CRISPR-Cas9 therefore allows us to investigate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cdabf63bd5a82f4577579eee92d4a8fe
https://pubmed.ncbi.nlm.nih.gov/35524121
https://pubmed.ncbi.nlm.nih.gov/35524121
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2477
Base editing is a CRISPR-Cas9 genome engineering tool that allows programmable mutagenesis without the creation of double-stranded breaks. Here, we describe the design and execution of large-scale base editing screens using the Target-AID base editor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f3001268ab1761b883566149239e4430
https://pubmed.ncbi.nlm.nih.gov/35524126
https://pubmed.ncbi.nlm.nih.gov/35524126
Autor:
Christian R. Landry, Clara Bleuven, Guillaume Quang N’Guyen, Marie Filteau, Philippe C Després
Publikováno v:
ISME J
The ability to measure microbial fitness directly in natural conditions and in interaction with other microbes is a challenge that needs to be overcome if we want to gain a better understanding of microbial fitness determinants in nature. Here we inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::727dcb35594d894e2cdd083e9cacf8f4
https://doi.org/10.1038/s41396-020-0612-8
https://doi.org/10.1038/s41396-020-0612-8