Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Philippe Bodin"'
Publikováno v:
Cellular and Molecular Life Sciences. 59:870-881
We investigated the expression of P2X4 and P2X6 receptors on human umbilical vein endothelial cells (HUVECs) and found that both P2X receptor subtypes on plasma membranes are largely restricted to areas of cell-cell contact. Co-labelling experiments
Autor:
Philippe Bodin, Geoffrey Burnstock
Publikováno v:
Journal of Cardiovascular Pharmacology. 38:900-908
In response to increased shear stress, vascular endothelial cells release adenosine triphosphate (ATP) by an unknown mechanism. We have investigated this mechanism using different approaches. First, we discovered that quinacrine, used to locate intra
Autor:
Anthony P.D.W. Ford, Weifang Rong, Philippe Bodin, Lubomir Kasakov, Geoffrey Burnstock, Michelle Bardini, Debra A. Cockayne, Mila Vlaskovska
Publikováno v:
The Journal of Neuroscience. 21:5670-5677
The present study explores the possible involvement of a purinergic mechanism in mechanosensory transduction in the bladder using P2X(3) receptor knock-out (P2X(3)(−)(/−)) and wild-type control (P2X(3)(+/+)) mice. Immunohistochemistry revealed ab
Autor:
Philippe Bodin, Geoffrey Burnstock
Publikováno v:
Neurochemical Research. 26:959-969
Adenosine triphosphate (ATP) has a fundamental intracellular role as the universal source of energy for all living cells. The demonstration of its release into the extracellular space and the identification and localisation of specific receptors on t
Publikováno v:
British Journal of Pharmacology. 129:921-926
Stimulation of endothelial cells from human umbilical vein by shear stress induced release of endogenous ATP which was accompanied by an extracellular increase in the activity of enzymes degrading both ATP (ATPases) and AMP (5′-nucleotidases). The
Publikováno v:
Molecular Genetics and Metabolism. 63:191-197
Reactive oxygen species (ROS) play an important role in the damage of vascular endothelium during atherogenesis and impaired endothelium-dependent vasorelaxation. We have studied the effect of two ROS generators (H2O2 and menadione) and one of the mo
Autor:
Rony Huys, Philippe Bodin
Publikováno v:
Ophelia. 46:217-231
Late cystacanth stages were discovered in the haemocoel of the marine benthic harpacticoid Halectinosoma herdmani (T. & A. Scott, 1896) (Copepoda: Ectinosomatidae) collected off La Rochelle, France. This represents the first record of Acanthocephala
Publikováno v:
Journal of Vascular Research. 33:139-145
Chronic rather than acute changes in the autonomic innervation of the vasculature are a feature of ageing and several cardiovascular disorders. To investigate the long-term influence of perivascular innervation on the vascular endothelium, the releas
Publikováno v:
Endothelium. 4:309-317
Human umbilical vessels are remarkable in lacking innervation; thus the role of the vascular endothelium is likely to be of prime importance in the local control of vascular tone. The vasoactive mediators arginine vasopressin (AVP), neuropeptide Y (N
Autor:
Geoffrey Burnstock, Philippe Bodin
Publikováno v:
Experientia. 51:256-259
Human umbilical vein endothelial cells (HUVECs) in primary cultures were perfused under normoxic or hypoxic conditions. These cells were stimulated twice for 3 min by increased flow (from 0.5 to 3.0 ml/min). Under hypoxic conditions the basal release