Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Philippe Bey"'
Autor:
Michel Baudry, Yubin Wang, Xiaoning Bi, Yun Lyna Luo, Zhijun Wang, Zeechan Kamal, Alexander Shirokov, Ed Sullivan, Dennis Lagasca, Hany Khalil, Gary Lee, Kathy Fosnaugh, Philippe Bey, Shujaath Mehdi, Greg Coulter
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 2, Pp n/a-n/a (2024)
Abstract Our laboratory has shown that calpain‐2 activation in the brain following acute injury is directly related to neuronal damage and the long‐term functional consequences of the injury, while calpain‐1 activation is generally neuroprotect
Externí odkaz:
https://doaj.org/article/6f9db8b3fcb74ef09bea457d69a31b76
Autor:
Gangadhar Taduri, Peter Keck, Raghu Kalluri, Philippe Bey, Hikaru Sugimoto, Désirée Tampe, Mary Rusckowski, Keizo Kanasaki, Dattatreyamurty Bosukonda, Valerie S. LeBleu, Michael Zeisberg, Wibke Bechtel, Hirokazu Okada, William D. Carlson, Björn Tampe
Publikováno v:
Nature Medicine. 18:396-404
Molecules associated with the transforming growth factor β (TGF-β) superfamily, such as bone morphogenic proteins (BMPs) and TGF-β, are key regulators of inflammation, apoptosis and cellular transitions. Here we show that the BMP receptor activin-
Autor:
Robert J. Resvick, Dirk Friedrich, Norton P. Peet, Burkhart Joseph P, Roy J. Vaz, Philippe Bey, Cynthia A. Gates, Philip M. Weintraub, Angelastro Michael R
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:929-934
20-Fluoro-17(20)-pregnenolone derivatives were designed as enol mimics of pregnenolone. All of the targeted, novel fluoroolefins were potent inhibitors of C 17(20) lyase.
Autor:
Hikaru Sugimoto, William D. Carlson, Valerie S. LeBleu, Raghu Kalluri, Keizo Kanasaki, Björn Tampe, Dattatreyamurty Bosukonda, Mary Rusckowski, Peter Keck, Désirée Tampe, Gangadhar Taduri, Philippe Bey, Wibke Bechtel, Michael Zeisberg, Hirokazu Okada
Publikováno v:
Nature medicine. 19(7)
Reply to Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3
Autor:
Michael R. Angelastro, Joseph P. Burkhart, M J Janusz, Chen Tm, Edward W. Huber, Koehl, Baugh Le, S L Durham, Philippe Bey, C M Hare
Publikováno v:
Journal of Medicinal Chemistry. 37:4538-4553
Valylprolylvalyl pentafluoroethyl ketones with different N-protecting groups were evaluated in vitro and in vivo as inhibitors of human neutrophil elastase (HNE). Several of these compounds were found to be orally active in HNE-induced rat and hamste
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:525-530
The concept of dual proteinase inhibition has been demonstrated with the preparation of unsymmetrical bis-terephthalamides.
Autor:
Norton P. Peet, Ann Marie L. Ogden, David A. Demeter, Herschel J. R. Weintraub, Elaine C. Meng, Mark W. Dudley, Nelsen L. Lentz, Philippe Bey
Publikováno v:
ChemInform. 22
Le nouveau mode de liaison propose est corrobore par des comparaisons de charges atomiques partielles, par une modelisation moleculaire, et une nouvelle synthese des xanthines, permettant l'introduction d'une unite de reconnaisance chirale en positio
Autor:
Jennifer A. Dumont, Albert Sjoerdsma, Edwards Michael L, Alan J. Bitonti, Peter P. McCann, Philippe Bey, D. M. Stemerick
Publikováno v:
ChemInform. 22
A series of novel tetraamines of the general formula RNH(CH2)xNH(CH2)yNH(CH2)xNHR was synthesized and examined for activity against growth of Plasmodium falciparum in vitro. Within the series, dibenzyl analogues (R = benzyl) were found to be the most
Autor:
Prasad S. Sunkara, Nellikunja J. Prakash, Philippe Bey, Donald P. Matthews, Terry L. Bowlin, James R. McCarthy, Edwards Michael L, Esa T. Jarvi, Shujaath Mehdi
Publikováno v:
ChemInform. 22
The design and synthesis of (E)- and (Z)-5'-fluoro-4',5'-didehydro-5'-deoxyadenosine (6 and 13, respectively), a new class of mechanism-based inhibitors of S-adenosyl-L-homocysteine (SAH) hydrolase, is described. A number of analogues of 6 and 13 wer
Publikováno v:
ChemInform. 22