Characterization of Aspirated Duodenal Fluids from Parkinson’s Disease Patients

Autor: Tom de Waal, Joachim Brouwers, Philippe Berben, Talia Flanagan, Jan Tack, Wim Vandenberghe, Tim Vanuytsel, Patrick Augustijns

Publikováno v: Pharmaceutics, Vol 15, Iss 4, p 1243 (2023)

Parkinson’s disease, one of the most common neurodegenerative diseases, may not only affect the motor system, but also the physiology of the gastrointestinal tract. Delayed gastric emptying, impaired motility and altered intestinal bacteria are wel

Externí odkaz: https://doaj.org/article/6520c5337e32421e88bc1d230ca741d8

Stimuli to the Revision Process: The Case for Apex Vessels

Autor: James Mann, Michael Cohen, Andreas Abend, Carrie Coutant, Lee Ashworth, Robert Shaw, Gavin Reynolds, Ishai Nir, Vivek Shah, Steven Shaw, Ashvin Patel, Xujin Lu, Vincent Cicale, Meagan McCallum, Sanjaykumar Patel, Josey Topolski, Steve Prüfer, Irena Tomaszewska, Alexandros Kourentas, Martin Mueller-Zsigmondy, Julian Williams, Matthew Ainge, Philippe Berben, Anne Bouquelle, Bertil Abrahamsson, Anders Karlsson, Ria Varghese, Fasheng Li, Amy Orce, Beverly Nickerson, Xi Shao

Publikováno v: Dissolution Technologies. 28:6-23

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7edcdf0ab948008dd9cf497a788d9c58
https://doi.org/10.14227/dt280421p6

Current challenges and future perspectives in oral absorption research : an opinion of the UNGAP network

Autor: Saskia N. de Wildt, Patrick Augustijns, Anette Müllertz, Mark McAllister, Cordula Stillhart, Brendan T. Griffin, James Butler, Kateřina Valentová, Andreas Bernkop-Schnürch, Nigel Davies, Caitriona M. O'Driscoll, Christos Reppas, Hannah Batchelor, Clive G. Wilson, Filippos Kesisoglou, Mirko Koziolek, Maria Vertzoni, Alan R. Mackie, Bertil Abrahamsson, Christopher J.H. Porter, Kiyohiko Sugano, Jadwiga Paszkowska, Zahari Vinarov, Didier Dupont, Martin Kuentz, Nikoletta Fotaki, Janneke Keemink, Jens Ceulemans, Petr Pavek, Gøril Eide Flaten, Elena Toader, Per Artursson, Vincent Jannin, Philippe Berben, Neil Parrott, Antonio J. Meléndez-Martínez

Publikováno v: Advanced Drug Delivery Reviews, 171, 289-331
Advanced Drug Delivery Reviews
Advanced Drug Delivery Reviews, Elsevier, 2021, 171, pp.289-331. ⟨10.1016/j.addr.2021.02.001⟩
Vinarov, Z, Abrahamsson, B, Artursson, P, Batchelor, H, Berben, P, Bernkop-Schnurch, A, Butler, J, Ceulemans, J, Davies, N, Dupont, D, Flaten, G E, Fotaki, N, Griffin, B T, Jannin, V, Keemink, J, Kesisoglou, F, Koziolek, M, Kuentz, M, Mackie, A, Melendez-Martinez, A J, McAllister, M, Mullertz, A, O'Driscoll, C M, Parrott, N, Paszkowska, J, Pavek, P, Porter, C J H, Reppas, C, Stillhart, C, Sugano, K, Toader, E, Valentova, K, Vertzoni, M, De Wildt, S N, Wilson, C G & Augustijns, P 2021, ' Current challenges and future perspectives in oral absorption research : An opinion of the UNGAP network ', Advanced Drug Delivery Reviews, vol. 171, pp. 289-331 . https://doi.org/10.1016/j.addr.2021.02.001
Advanced Drug Delivery Reviews, 171, pp. 289-331

Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33eec6da8069c781165c09e0bfc8b4fe
https://strathprints.strath.ac.uk/75801/1/Vinarov_etal_ADDR_2021_Current_challenges_and_future_perspectives_in_oral_absorption_research.pdf

Biorelevant dissolution testing of a weak base: Interlaboratory reproducibility and investigation of parameters controlling in vitro precipitation

Autor: Irena Tomaszewska, James Butler, Jean-Luc Bruel, Krista Ojala, Janine Nicolai, Lukas Klumpp, Jan Bevernage, Paul Hutchins, James Williams, Lee Ashworth, Stefania Beato, Sanjaykumar Patel, Philippe Berben, Sarah Powell, Patrick Augustijns, Karin Rosenblatt, Jennifer B. Dressman, James Mann, Kerstin Julia Schäfer

Following a previous study which aimed to determine the interlaboratory reproducibility of biorelevant dissolution testing in the USP 2 apparatus for commercial formulations of two weak acids (ibuprofen and zafirlukast), this study attempts to determ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7cc1730a3c6e0566229ab412ff1e37d
https://lirias.kuleuven.be/handle/123456789/638277

Linking the concentrations of itraconazole and 2-hydroxypropyl-β-cyclodextrin in human intestinal fluids after oral intake of Sporanox®

Autor: Patrick Augustijns, Govert W. Somsen, Elena Domínguez-Vega, Joachim Brouwers, Jef Stappaerts, Philippe Berben, Matthias J.A. Vink

Publikováno v: Berben, P, Stappaerts, J, Vink, M J A, Domínguez-Vega, E, Somsen, G W, Brouwers, J & Augustijns, P 2018, ' Linking the concentrations of itraconazole and 2-hydroxypropyl-β-cyclodextrin in human intestinal fluids after oral intake of Sporanox ® ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 132, pp. 231-236 . https://doi.org/10.1016/j.ejpb.2018.06.025
European Journal of Pharmaceutics and Biopharmaceutics, 132, 231-236. Elsevier

In a previously performed small-scale clinical study, healthy volunteers were asked to ingest an oral solution of itraconazole (Sporanox®) containing 40% 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) (i) with or (ii) without a standardized volume of wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8efcf23472001ede2121b97bf65daf1c
https://lirias.kuleuven.be/handle/123456789/628988