Výsledky vyhledávání - "Philippe Bedos"

The alkaloid centcyamine increases expression of klotho and lamin B1, slowing the onset of skin ageing in vitro and in vivo

Autor: Karl Lintner, Claire Leduc, Sophie Abadie, Philippe Bedos

Publikováno v: International Journal of Cosmetic Science. 43:561-572

Klotho is a protein known for its beneficial effects on longevity. Centcyamine is an alkaloid present in certain plants whose extracts have an anti-inflammatory effect. Skin fibroblasts are essential to the formation and structure of the dermis.Centc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5cc7d6b01b70bed1d824dd3032c78ae
https://doi.org/10.1111/ics.12731

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Synthesis and Biological Evaluation of Bradykinin B1/B2 and Selective B1 Receptor Antagonists

Autor: Jean Martinez, Jean-Michel Luccarini, Pierre Dodey, Isabelle Daffix, Jean-Luc Paquet, Muriel Amblard, Philippe Bedos, Didier Pruneau, Christophe Olivier

Publikováno v: Journal of Medicinal Chemistry. 43:2382-2386

We recently described a potent bradykinin B(2) receptor agonist (JMV1116) obtained by replacing the D-Tic-Oic dipeptide moiety of HOE140 by a (3S)-amino-5-(carbonylmethyl)-2,3-dihydro-1, 5-benzothiazepin-4(5H)-one (D-BT) moiety. This compound inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f48b33620d57e24ae2cbfaa18af8f2d
https://doi.org/10.1021/jm990961s

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Design and Synthesis of Potent Bradykinin Agonists Containing a Benzothiazepine Moiety

Autor: Jean Martinez, Pierre Bélichard, Jean-Luc Paquet, Pierre Dodey, Didier Pruneau, Gilbert Bergé, Isabelle Daffix, Philippe Bedos, Muriel Amblard, Jean-Michel Luccarini

Publikováno v: Journal of Medicinal Chemistry. 42:4185-4192

A bradykinin analogue (H-Arg-Pro-Pro-Gly-Phe-Ser-D-BT-Arg-OH, 3) in which the Pro-Phe dipeptide was replaced by the (3S)[amino]-5-(carbonylmethyl)-2,3-dihydro-1, 5-benzothiazepin-4(5H)-one (D-BT) moiety has been synthesized. The same modification was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe1c133b8ba3c3e1b1343a027cbfa637
https://doi.org/10.1021/jm9901529

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Recent advances in phosphono- and phosphinopeptide synthesis

Autor: Patrick Jouin, Jacques Coste, Nathalie Galéotti, Jean-Marc Campagne, Philippe Bedos, Laurent Le Guillou

Publikováno v: Letters in Peptide Science. 2:233-238

Phosphopeptides have been described as protease inhibitors as well as haptens for the preparation of abzymes exhibiting esterase activity. Phosphono- or phosphinopeptides have previously been prepared by solution synthesis, starting from the fully pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ab535888aa1bc2e04f081f5728a4724
https://doi.org/10.1007/bf00119161

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Optimization of spiroimidazolidinone derivatives synthesis on solid phase using SynPhase™ Lanterns

Autor: Lidia Feliu, Philippe Bedos, Jean Martinez, Muriel Amblard

Publikováno v: Tetrahedron Letters. 44:4937-4939

We report the synthesis of 1,4,8-triazaspiro[4.5]decan-2-one derivatives from N -benzyl-4-piperidone and N -protected amino acid amides on solid support. We have translated the chemistry from solution to solid phase using a backbone amide linker (BAL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a6e6cad998ff7398d570c598fe2c9ba
https://doi.org/10.1016/s0040-4039(03)01083-9

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ChemInform Abstract: A Straightforward Synthesis of α-Amino Phosphonate Monoesters Using BroP or TPyCIU

Autor: Philippe Bedos, Jacques Coste, Patrick Jouin, Nathalie Galéotti

Publikováno v: ChemInform. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02e01ac201cc17680b369c72ff15f7af
https://doi.org/10.1002/chin.199639223

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A rational approach to the design and synthesis of a new bradykinin B(1) receptor antagonist

Autor: Gilles Subra, ‡ Jean-Michel Luccarini, Philippe Bedos, Jean Martinez, Pierre Dodey, Didier Pruneau, ‡ Jean-Luc Paquet, Muriel Amblard, and André Aumelas

Publikováno v: Journal of medicinal chemistry. 43(12)

We have previously synthesized a potent and selective B(1) bradykinin receptor antagonist, JMV1645 (H-Lys-Arg-Pro-Hyp-Gly-Igl-Ser-D-BT-OH), containing a dipeptide mimetic ((3S)-amino-5-carbonylmethyl-2,3-dihydro-1, 5-benzothiazepin-4(5H)-one (D-BT) m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e9e46611f92a27daf18d1617605aa8
https://pubmed.ncbi.nlm.nih.gov/10882365

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A straightforward synthesis of α-amino phosphonate monoesters using BroP or TPyClU

Autor: Philippe Bedos, Patrick Jouin, Nathalie Galéotti, Jacques Coste

Publikováno v: Tetrahedron Letters. 37:3997-3998

Monoesters of N-protected α-amino phosphonic acid were prepared from phosphonic acid using BroP or TPyClU as activating agent. This reaction proceeds with good yield, even with hindered alcohols.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0dbc9450f49961a9a53966a7f925f9fc
https://doi.org/10.1016/0040-4039(96)00742-3

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