Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Philippe Azam"'
Autor:
Elena Goicoechea de Jorge, H. Terence Cook, Matthew C. Pickering, Philippe Azam, Frédérique Brune, Fadi Fakhouri
Publikováno v:
Kidney International. 78(3):279-286
Total deficiency of complement factor H (CFH) is associated with dense deposit disease (DDD) and atypical haemolytic uraemic syndrome (aHUS). CFH is the major regulator of the alternative pathway of complement activation and its complete deficiency r
Autor:
James E. Melvin, Ossama A. Hatoum, Heike Wulff, Kazuyoshi Toyama, Takashi Saito, David L. Mattson, Philippe Azam, Girija Raman, David R. Harder, Hiroto Miura, David D. Gutterman, Phillip F. Pratt, K. George Chandy, Satarupa Das, Yoshimasa Fujiwara
Publikováno v:
Journal of Clinical Investigation. 118:3025-3037
Atherosclerosis remains a major cause of death in the developed world despite the success of therapies that lower cholesterol and BP. The intermediate-conductance calcium-activated potassium channel KCa3.1 is expressed in multiple cell types implicat
Autor:
Philippe Azam, Heike Wulff, Daniel Homerick, Ananthakrishnan Sankaranarayanan, Stephen M Griffey
Publikováno v:
Journal of Investigative Dermatology. 127:1419-1429
The voltage-gated potassium channel Kv1.3 has been recently identified as a molecular target that allows for selective pharmacological suppression of effector memory T (T(EM)) cells without affecting the function of naïve and central memory T cells.
Autor:
Heike Wulff, Christine Beeton, Jamshid Tehranzadeh, Nathan Standifer, Stephen M Griffey, Werner W. Roeck, Christine J. LeeHealey, Philippe Azam, Brian S. Andrews, Alexandra Grino, Debra Counts, K. George Chandy, George A. Gutman, Kimber L. Stanhope, Ananthakrishnan Sankaranarayanan, Ping H. Wang, Katherine M. Mullen, Daniel Homerick, Pavel I. Zimin, Peter J. Havel, Michael W. Pennington, Aaron Kolski-Andreaco, Eric Wei, Peter A. Calabresi, Gerald T. Nepom, Hans Guenther Knaus
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 103, iss 46
Beeton, Christine; Wulff, Heike; Standifer, Nathan E; Azam, Philippe; Mullen, Katherine M; Pennington, Michael W; et al.(2006). Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases.. Proceedings of the National Academy of Sciences of the United States of America, 103(46), 17414-17419. doi: 10.1073/pnas.0605136103. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/2647b9c5
Beeton, Christine; Wulff, Heike; Standifer, Nathan E; Azam, Philippe; Mullen, Katherine M; Pennington, Michael W; et al.(2006). Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases.. Proceedings of the National Academy of Sciences of the United States of America, 103(46), 17414-17419. doi: 10.1073/pnas.0605136103. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/2647b9c5
Autoreactive memory T lymphocytes are implicated in the pathogenesis of autoimmune diseases. Here we demonstrate that disease-associated autoreactive T cells from patients with type-1 diabetes mellitus or rheumatoid arthritis (RA) are mainly CD4+CCR7
Autor:
Laurence Vian, Pierre-Antoine Bonnet, Isabelle Fabre, Delphine Chamousset, Jean-Claude Ourlin, Jean-Luc Peiffer, Marie-Hélène Tissier, Philippe Azam
Publikováno v:
Toxicology and Applied Pharmacology. 212:14-23
Langerhans cells (LC) are key mediators of contact allergenicity in the skin. However, no in vitro methods exist which are based on the activation process of LC to predict the sensitization potential of chemicals. In this study, we have evaluated the
Autor:
Ananthakrishnan Sankaranarayanan, Daniel Homerick, Wolfram Hänsel, Heike Wulff, Alexander Schmitz, Philippe Azam, Kristina Schmidt-Lassen
Publikováno v:
Molecular Pharmacology. 68:1254-1270
The lymphocyte K+ channel Kv1.3 constitutes an attractive pharmacological target for the selective suppression of terminally differentiated effector memory T (TEM) cells in T cell-mediated autoimmune diseases, such as multiple sclerosis and type 1 di
Autor:
Philippe Azam, Pierre-Antoine Bonnet, Isabelle Fabre, Laurence Vian, Jean-Claude Ourlin, Marie-Hélène Tissier, Jean-Luc Peiffer
Publikováno v:
Toxicology. 206:285-298
The local lymph node assay (LLNA) is a regular method for the detection of sensitizing chemicals in mice which measures the incorporation of tritiated thymidine in lymph node cells. We have evaluated an alternative to this method based on the interle
Autor:
Yannick Gueguen, Jean-Luc Rolland, Jean-Paul Raffin, Jacques Dietrich, Didier Flament, Philippe Azam, Gisèle Le Romancer, Odile Lecompte
Publikováno v:
European Journal of Biochemistry. 268:5961-5969
The complete genome sequence of the hyperthermophilic archaeon Pyrococcus abyssi revealed the presence of a family B DNA polymerase (Pol I) and a family D DNA polymerase (Pol II). To extend our knowledge about euryarchaeal DNA polymerases, we cloned
Autor:
Ananthakrishnan Sankaranaryanan, Heike Wulff, Philippe Azam, Wolfram Hänsel, Alexander Schmitz
Publikováno v:
The FASEB Journal. 20
Autor:
Didier Flament, Jacques Dietrich, Joël Querellou, Jean-Paul Raffin, Ulrich Hübscher, Philippe Azam, Yannick Gueguen, Ghislaine Henneke
Publikováno v:
Journal of Molecular Biology (0022-2836) (Elsevier), 2002-11, Vol. 323, N. 5, P. 795-810
The molecular organization of the replication complex in archaea is similar to that in eukaryotes. Only two proteins homologous to subunits of eukaryotic replication factor C (RFC) have been detected in Pyrococcus abyssi (Pab). The genes encoding the